| Title: |
Type I Interferon Signaling Exacerbates Chlamydia muridarum Genital Infection in a Murine Model |
| Authors: |
Nagarajan, Uma M.; Prantner, Daniel; Sikes, James D.; Andrews, Charles W.; Goodwin, Anna M.; Nagarajan, Shanmugam; Darville, Toni |
| Source: |
Infection and Immunity ; volume 76, issue 10, page 4642-4648 ; ISSN 0019-9567 1098-5522 |
| Publisher Information: |
American Society for Microbiology |
| Publication Year: |
2008 |
| Description: |
Type I interferons (IFNs) induced during in vitro chlamydial infection exert bactericidal and immunomodulatory functions. To determine the precise role of type I IFNs during in vivo chlamydial genital infection, we examined the course and outcome of Chlamydia muridarum genital infection in mice genetically deficient in the receptor for type I IFNs (IFNAR −/− mice). A significant reduction in chlamydial shedding and duration of lower genital tract infection was observed in IFNAR −/− mice in comparison to the level of chlamydial shedding and duration of infection in wild-type (WT) mice. Furthermore, IFNAR −/− mice developed less chronic oviduct pathology in comparison to that in WT mice. Compared to the WT, IFNAR −/− mice had a greater number of chlamydial-specific T cells in their iliac lymph nodes 21 days postinfection. IFNAR −/− mice also exhibited earlier and enhanced CD4 T-cell recruitment to the cervical tissues, which was associated with increased expression of CXCL9 in the genital secretions of IFNAR −/− mice, but not with expression of CXCL10, which was reduced in the genital secretions of IFNAR −/− mice. These data suggest that type I IFNs exacerbate C. muridarum genital infection through an inhibition of the chlamydial-specific CD4 T-cell response. |
| Document Type: |
article in journal/newspaper |
| Language: |
English |
| DOI: |
10.1128/iai.00629-08 |
| DOI: |
10.1128/IAI.00629-08 |
| Availability: |
https://doi.org/10.1128/iai.00629-08; https://journals.asm.org/doi/pdf/10.1128/IAI.00629-08 |
| Rights: |
https://journals.asm.org/non-commercial-tdm-license |
| Accession Number: |
edsbas.7DDB692 |
| Database: |
BASE |