| Title: |
MyD88 and TLR4 Expression in Epithelial Ovarian Cancer |
| Authors: |
Block, MS; Vierkant, RA; Rambau, PF; Winham, SJ; Wagner, P; Traficante, N; Toloczko, A; Tiezzi, DG; Taran, FA; Sinn, P; Sieh, W; Sharma, R; Rothstein, JH; Ramón y Cajal, T; Paz-Ares, L; Oszurek, O; Orsulic, S; Ness, RB; Nelson, G; Modugno, F; Menkiszak, J; McGuire, V; McCauley, BM; Mack, M; Lubinski, J; Longacre, TA; Li, Z; Lester, J; Kennedy, CJ; Kalli, KR; Jung, AY; Johnatty, SE; Jimenez-Linan, M; Jensen, A; Intermaggio, MP; Hung, J; Herpel, E; Hernandez, BY; Hartkopf, AD; Harnett, PR; Ghatage, P; García-Bueno, JM; Gao, B; Fereday, S; Eilber, U; Edwards, RP; de Sousa, CB; de Andrade, JM; Chudecka-Glaz, A; Chenevix-Trench, G; Cazorla, A; Brucker, SY; Bowtell, DD; Green, A; Webb, P; de Fazio, A; Gertig, D; Moore, S; Harrap, K; Sadkowsky, T; Pandeya, N; Malt, M; Mellon, A; Robertson, R; Vanden Bergh, T; Jones, M; Mackenzie, P; Maidens, J; Nattress, K; Chiew, YE; Stenlake, A; Sullivan, H; Alexander, B; Ashover, P; Brown, S; Corrish, T; Green, L; Jackman, L; Ferguson, K; Martin, K; Martyn, A; Ranieri, B; White, J; Jayde, V; Mamers, P; Bowes, L; Galletta, L; Giles, D; Hendley, J; Alsop, K; Schmidt, T; Shirley, H; Ball, C; Young, C; Viduka, S; Tran, H; Bilic, S; Glavinas, L; Brooks, J; Stuart-Harris, R |
| Publisher Information: |
ELSEVIER SCIENCE INC |
| Publication Year: |
2018 |
| Collection: |
The University of Melbourne: Digital Repository |
| Description: |
OBJECTIVE: To evaluate myeloid differentiation primary response gene 88 (MyD88) and Toll-like receptor 4 (TLR4) expression in relation to clinical features of epithelial ovarian cancer, histologic subtypes, and overall survival. PATIENTS AND METHODS: We conducted centralized immunohistochemical staining, semi-quantitative scoring, and survival analysis in 5263 patients participating in the Ovarian Tumor Tissue Analysis consortium. Patients were diagnosed between January 1, 1978, and December 31, 2014, including 2865 high-grade serous ovarian carcinomas (HGSOCs), with more than 12,000 person-years of follow-up time. Tissue microarrays were stained for MyD88 and TLR4, and staining intensity was classified using a 2-tiered system for each marker (weak vs strong). RESULTS: Expression of MyD88 and TLR4 was similar in all histotypes except clear cell ovarian cancer, which showed reduced expression compared with other histotypes (P |
| Document Type: |
article in journal/newspaper |
| Language: |
English |
| ISSN: |
0025-6196 |
| Relation: |
NHMRC/310670; NHMRC/400281; NHMRC/628903; NHMRC/400413; https://hdl.handle.net/11343/256043 |
| Availability: |
https://hdl.handle.net/11343/256043 |
| Rights: |
https://creativecommons.org/licenses/by-nc-nd/4.0 ; CC BY-NC-ND |
| Accession Number: |
edsbas.7E8E435B |
| Database: |
BASE |