| Title: |
First-year oral antidiabetic adherence and long-term complications in newly diagnosed type 2 diabetes |
| Authors: |
Kim, NH; Moon, JS; Ha, KH; Kim, J; Kwon, KE; Kim, SG; Kim, DJ |
| Contributors: |
105006; Kim, DJ |
| Publication Year: |
2025 |
| Subject Terms: |
Administration; Oral; Adult; Aged; Diabetes Mellitus; Type 2; Female; Hospitalization; Humans; Hypoglycemic Agents; Male; Medication Adherence; Middle Aged; Retrospective Studies; Adherence; Complications; Oral Antidiabetic Drugs; Retrospective Cohort Study; Type 2 Diabetes |
| Description: |
AIMS: Type 2 diabetes (T2D) is a growing public health issue, with early treatment adherence potentially impacting long-term outcomes. This study assessed the association between adherence to oral antidiabetic drugs (OADs) during the first year after diagnosis and the risk of complications and mortality. METHODS: A retrospective cohort study was conducted using a nationally representative health claims database. Patients newly diagnosed with T2D in 2009 who initiated OAD monotherapy within 12 months were included. Follow-up continued from the adherence index date until death, loss of follow-up, or study end. Patients were categorized by adherence level during the first year: good (>/= 80 %) and poor (< 80 %). Outcomes included macrovascular events, diabetes-related hospitalizations, and all-cause mortality. Hazard ratios were estimated using Cox proportional hazards models with inverse probability of treatment weighting. RESULTS: Among 65,340 patients, 46.9 % (n = 30,657) showed good adherence. Compared to poor adherence, good adherence was associated with a 23 % lower risk of macrovascular events, an 8% lower risk of diabetes-related hospitalizations, and a 28 % lower risk of all-cause mortality. CONCLUSIONS: Early adherence to OADs was associated with a reduced risk of complications and mortality in T2D patients. Promoting adherence in newly diagnosed individuals is crucial for improving long-term outcomes. |
| Document Type: |
article in journal/newspaper |
| Language: |
English |
| Relation: |
J001688227; http://repository.ajou.ac.kr/handle/201003/34459 |
| DOI: |
10.1016/j.diabres.2025.112405 |
| Availability: |
http://repository.ajou.ac.kr/handle/201003/34459; https://linkinghub.elsevier.com/retrieve/pii/S0168-8227(25)00419-X; https://doi.org/10.1016/j.diabres.2025.112405 |
| Accession Number: |
edsbas.7EAC342E |
| Database: |
BASE |