| Title: |
Resolution of Inflammation and Gut Repair in IBD: Translational Steps Towards Complete Mucosal Healing |
| Authors: |
Ho, Gwo-tzer; Cartwright, Jennifer A; Thompson, Emily J; Bain, Calum C; Rossi, Adriano G |
| Contributors: |
Wellcome Trust; European Research Council Consolidator; Wellcome Trust and the Royal Society; MRC Programme grant; MRC SHIELD consortium |
| Source: |
Inflammatory Bowel Diseases ; volume 26, issue 8, page 1131-1143 ; ISSN 1078-0998 1536-4844 |
| Publisher Information: |
Oxford University Press (OUP) |
| Publication Year: |
2020 |
| Description: |
Despite significant recent therapeutic advances, complete mucosal healing remains a difficult treatment target for many patients with inflammatory bowel diseases (IBD) to achieve. Our review focuses on the translational concept of promoting resolution of inflammation and repair as a necessary adjunctive step to reach this goal. We explore the roles of inflammatory cell apoptosis and efferocytosis to promote resolution, the new knowledge of gut monocyte-macrophage populations and their secreted prorepair mediators, and the processes of gut epithelial repair and regeneration to bridge this gap. We discuss the need and rationale for this vision and the tangible steps toward integrating proresolution therapies in IBD. |
| Document Type: |
article in journal/newspaper |
| Language: |
English |
| DOI: |
10.1093/ibd/izaa045 |
| Availability: |
https://doi.org/10.1093/ibd/izaa045; http://academic.oup.com/ibdjournal/article-pdf/26/8/1131/33505140/izaa045.pdf |
| Rights: |
https://academic.oup.com/journals/pages/open_access/funder_policies/chorus/standard_publication_model |
| Accession Number: |
edsbas.7EC2C960 |
| Database: |
BASE |