Disease activity, severity, and damage in the UK juvenile-onset systemic lupus erythematosus cohort
| Title: | Disease activity, severity, and damage in the UK juvenile-onset systemic lupus erythematosus cohort |
|---|---|
| Authors: | Watson, Louise; Leone, Valentina; Pilkington, Clarissa; Tullus, Kjell; Rangaraj, Satyapal; McDonagh, Janet E.; Gardner-Medwin, Janet; Wilkinson, Nick; Riley, Phil; Tizard, Jane; Armon, Kate; Sinha, Manish; Ioannou, Yiannis; Archer, Neil; Bailey, Kathryn; Davidson, Joyce; Baildam, Eileen M.; Cleary, Gavin; McCann, Liza J.; Beresford, Michael W. |
| Source: | Watson, L, Leone, V, Pilkington, C, Tullus, K, Rangaraj, S, McDonagh, J E, Gardner-Medwin, J, Wilkinson, N, Riley, P, Tizard, J, Armon, K, Sinha, M, Ioannou, Y, Archer, N, Bailey, K, Davidson, J, Baildam, E M, Cleary, G, McCann, L J, Beresford, M W 2012, 'Disease activity, severity, and damage in the UK juvenile-onset systemic lupus erythematosus cohort', Arthritis & Rheumatism, vol. 64, no. 7, pp. 2356-2365. https://doi.org/10.1002/art.34410 |
| Publication Year: | 2012 |
| Collection: | King's College, London: Research Portal |
| Subject Terms: | PEDIATRIC RHEUMATIC-DISEASES; CHILDHOOD-ONSET; ACTIVITY INDEX; ADULT-ONSET; INTRAVENOUS CYCLOPHOSPHAMIDE; INITIAL VALIDATION; CLINICAL-FEATURES; BILAG-2004 INDEX; POPULATION; MORTALITY |
| Description: | Objective The UK Juvenile-Onset Systemic Lupus Erythematosus (JSLE) Cohort Study is a multicenter collaborative network established with the aim of improving the understanding of juvenile SLE. The present study was undertaken to describe the clinical manifestations and disease course in patients with juvenile SLE from this large, national inception cohort. Methods Detailed data on clinical phenotype were collected at baseline and at regular clinic reviews and annual followup assessments in 232 patients from 14 centers across the UK over 4.5 years. Patients with SLE were identified according to the American College of Rheumatology (ACR) SLE classification criteria. The present cohort comprised children with juvenile SLE (n = 198) whose diagnosis fulfilled =4 of the ACR criteria for SLE. Results Among patients with juvenile SLE, the female:male sex distribution was 5.6:1 and the median age at diagnosis was 12.6 years (interquartile range 10.414.5 years). Male patients were younger than female patients (P |
| Document Type: | article in journal/newspaper |
| Language: | English |
| ISSN: | 0004-3591; 1529-0131 |
| Relation: | info:eu-repo/semantics/altIdentifier/wos/000305742800032; info:eu-repo/semantics/altIdentifier/pissn/0004-3591; info:eu-repo/semantics/altIdentifier/eissn/1529-0131 |
| DOI: | 10.1002/art.34410 |
| Availability: | https://kclpure.kcl.ac.uk/portal/en/publications/5f2abecf-d4c4-4f0a-a467-b8a521543aca; https://doi.org/10.1002/art.34410 |
| Rights: | info:eu-repo/semantics/openAccess |
| Accession Number: | edsbas.7ED38D61 |
| Database: | BASE |