| Title: |
Outcomes of intended temporary stomas in Crohn's disease (INTESTINE study): international, multicentre, retrospective study |
| Authors: |
Perrott, Claire; Calini, Giacomo; Gori, Alice; Rottoli, Matteo; Flacco, Maria E; Manzoli, Lamberto; Garoufalia, Zoe; Wexner, Steven D; Kontovounisios, Christos; Elhadi, Muhammed; Celentano, Valerio; null, null; Avellaneda, N; Potolicchio, A; Muñoz, J P; Abdelrahman, A S; Mostafa, Sara Mansour; de' Angelis, N; Schena, C A; Marchegiani, F; Kelm, M; Flemming, S; Lock, J; Politis, D; Ioannis, P; Mangana, O; Chardalias, L; Zager, Y; Horesh, N; Calini, G; Terrosu, G; Martinuzzo, L; Muschitiello, D; Biddau, C; Braini, A; Tumminelli, F; Gori, A; Rottoli, M; Cardelli, S; Belvedere, A; Isopi, C; Gallo, G; Trompetto, M; Clerico, G; Realis Luc, A; Mingoli, A; Lapolla, P; Brachini, G; Mazzarella, G; Ghazouani, O; Galleano, R; Malerba, M; Menegon Tasselli, F; Pellino, G; Rizzo, G; Cappello, M; Carrozza, L; Muttillo, I A; Muttillo, E M; Picardi, B; Bazzi, N; Dbouk, S; Chaalan, Z; Bazzi, M; Alkaseek, A; Bileid Bakeer, H; Shames, H; Aboudlal, H; Kredan, A; Qutaiba, Q; Abu Rumaila, A Y; Al Safwan, J Q; Al Turki, N A; Bunyian, A; Fernandes Montes, N; Martí Gallostra, M; Pintos Garza, R; Vigorita, V; Moncada Iribarren, E; De Ariño-Hervas, I; Aguirre-Allende, I; Enriquez-Navascués, J M; Padilla-Otamendi, M J; Sanchez-Rodriguez, M; Pérez-Carpio, C; Tejedor, P; Velayos Herraez, D; Cancelas Felgueras, M D; Estaire Gómez, M; Cagigal Ortega, E P; Plazas, D; Millan, M; Gutierrez, C; Montalbán, P; Blanco-Antona, F; Valera Montiel, A E; Kozan, R; Leventoglu, S; Ceylan, H H; Ozaydin, S; Bostanci, E B; Colak, T; Ozcan, C; Eray, I C; Aytaç, E; Selvakumar, D; Hancock, L; Jabble, N; Warrington, D; Ahmed, N; Hussain, T; Cooper, J; Gendia, A; Ahmed, J; Exarchou, K; Eardley, N; Davies, B; Manzo, C A; Celentano, V; Pérez-Ajates, S; Seth, S; Sriskandarajah, K; Chouari, T; Matthews, E; Bethune, R; Abuelgasim, M; Smith, A; Brownson, E; Nicholson, G; Campbell, I; Subramanian, A; Tonsi, A; Siby, J; Garoufalia, Z; Wexner, S D; Zhou, P; Gefen, R; Arjonilla, M; Monzur, F; Al-Sadawi, M; Elhadi, M; Perrott, C; Kontovounisios, C; Blackwell, S; Perrot, C |
| Contributors: |
Perrott, Claire; Calini, Giacomo; Gori, Alice; Rottoli, Matteo; Flacco, Maria E; Manzoli, Lamberto; Garoufalia, Zoe; Wexner, Steven D; Kontovounisios, Christo; Elhadi, Muhammed; Celentano, Valerio; Null, Null; Avellaneda, N; Potolicchio, A; Muñoz, J P; Abdelrahman, A S; Mostafa, Sara Mansour; De' Angelis, N; Schena, C A; Marchegiani, F; Kelm, M; Flemming, S; Lock, J; Politis, D; Ioannis, P; Mangana, O; Chardalias, L; Zager, Y; Horesh, N; Calini, G; Terrosu, G; Martinuzzo, L; Muschitiello, D; Biddau, C; Braini, A; Tumminelli, F; Gori, A; Rottoli, M; Cardelli, S; Belvedere, A; Isopi, C; Gallo, G; Trompetto, M; Clerico, G; Realis Luc, A; Mingoli, A; Lapolla, P; Brachini, G; Mazzarella, G; Ghazouani, O; Galleano, R; Malerba, M; Menegon Tasselli, F; Pellino, G; Rizzo, G; Cappello, M; Carrozza, L; Muttillo, I A; Muttillo, E M; Picardi, B; Bazzi, N; Dbouk, S; Chaalan, Z; Bazzi, M; Alkaseek, A; Bileid Bakeer, H; Shames, H; Aboudlal, H; Kredan, A; Qutaiba, Q; Abu Rumaila, A Y; Al Safwan, J Q; Al Turki, N A; Bunyian, A; Fernandes Montes, N; Martí Gallostra, M; Pintos Garza, R; Vigorita, V; Moncada Iribarren, E; De Ariño-Hervas, I; Aguirre-Allende, I; Enriquez-Navascués, J M; Padilla-Otamendi, M J; Sanchez-Rodriguez, M; Pérez-Carpio, C; Tejedor, P; Velayos Herraez, D; Cancelas Felgueras, M D; Estaire Gómez, M; Cagigal Ortega, E P; Plazas, D; Millan, M; Gutierrez, C; Montalbán, P; Blanco-Antona, F; Valera Montiel, A E; Kozan, R |
| Publication Year: |
2025 |
| Collection: |
IRIS Università degli Studi di Bologna (CRIS - Current Research Information System) |
| Subject Terms: |
stoma; Crohn's disease; INTESTINE; international; multicentre; retrospective |
| Description: |
Background: Patients with ileocolic Crohn's disease often require surgery that can result in temporary stoma formation. Stomas are associated with a morbidity and can negatively impact quality of life. This study aimed to investigate the short-term (6-month) and mid-term (18-month) outcomes of intended temporary stomas in patients with Crohn's disease. Methods: A trainee-led, international multicentre, retrospective study was conducted on all patients who underwent surgery for Crohn's disease in collaborating centres over 4 years (2017-2020). The primary outcome was the proportion of patients with Crohn's disease who underwent stoma reversal surgery by 6- and 18-month postoperative follow-up. Secondary outcomes included: the time interval between formation and reversal of stoma and predictors for non-reversal and stoma-related morbidity (postoperative complications, related readmissions and complications due to stoma reversal surgery). Results: A total of 401 patients underwent stoma formation for Crohn's disease over the 4 years across the 44 collaborating centres. The temporary stomas had been reversed in 30.2% of patients at the 6-month and 56.9% at the 18-month follow-up. Reasons for non-reversal included ongoing medical treatment for Crohn's disease (respectively 6-month and 18-month: 37.6%, 39.3%), patient unfit for surgery (respectively 6-month and 18-month: 14.5%, 16.8%), patient preference (respectively 6-month and 18-month: 12.1%, 20.2%) and due to waiting lists (respectively 6-month and 18-month: 12.1%, 8.1%). Overall, 63.3% of patients had a temporary stoma reversed with a median time interval of 6 months. The stoma-related overall morbidity rate was 29.4%. Conclusions: A large proportion of temporary stomas for Crohn's disease were not reversed at 6 and 18 months following initial surgery. Patients are exposed to the risk of non-reversal and risk of developing stoma complications for significantly longer intervals of time and, in some cases, indefinitely. |
| Document Type: |
article in journal/newspaper |
| File Description: |
ELETTRONICO |
| Language: |
English |
| Relation: |
info:eu-repo/semantics/altIdentifier/pmid/40454941; info:eu-repo/semantics/altIdentifier/wos/WOS:001500056300001; volume:9; issue:3; firstpage:1; lastpage:14; numberofpages:14; journal:BJS OPEN; https://hdl.handle.net/11585/1016953; https://academic.oup.com/bjsopen/article/9/3/zraf010/8155054?login=true |
| DOI: |
10.1093/bjsopen/zraf010 |
| Availability: |
https://hdl.handle.net/11585/1016953; https://doi.org/10.1093/bjsopen/zraf010; https://academic.oup.com/bjsopen/article/9/3/zraf010/8155054?login=true |
| Rights: |
info:eu-repo/semantics/openAccess ; license:Licenza per Accesso Aperto. Creative Commons Attribuzione (CCBY) ; license uri:iris.PUB15 |
| Accession Number: |
edsbas.7ED5D4E6 |
| Database: |
BASE |