| Title: |
Sociodemographic, Clinical, and Pathological Factors Influencing Outcomes in Locally Advanced Triple Negative Breast Cancer: A Brazilian Cohort |
| Authors: |
Jesse Lopes da Silva; Bruno Henrique Rala de Paula; Isabele Avila Small; Luiz Claudio Santos Thuler; Andréia Cristina de Melo |
| Source: |
Breast Cancer: Basic and Clinical Research, Vol 14 (2020) |
| Publisher Information: |
SAGE Publishing |
| Publication Year: |
2020 |
| Collection: |
Directory of Open Access Journals: DOAJ Articles |
| Subject Terms: |
Neoplasms. Tumors. Oncology. Including cancer and carcinogens; RC254-282 |
| Description: |
Objective: To evaluate the association of sociodemographic, clinical, and pathological factors with response and survival in triple negative breast cancer (TNBC) undergoing neoadjuvant chemotherapy (NACT). Methods: Clinical-pathological and sociodemographic data were obtained from medical records of 235 eligible women with TNBC diagnosed between 2010 and 2014 undergoing NACT and surgery at the Brazilian National Cancer Institute. They have been assessed for pathological complete response (pCR), event-free survival (EFS), and overall survival (OS). Both univariate and multivariate Cox regression analyses were performed. Results: The median follow-up was 64.3 months. Most patients had advanced clinical stage (III: 85.1%; cT3/T4: 86.4%; cN1-3: 74.4%) and high-grade tumors (72.1%). Clinical staging (III vs II, adjusted hazard ratio [HR] = 2.95, P = .012) significantly influenced the pCR rate. Alcohol intake negatively influenced EFS (adjusted HR = 1.67, P = .006) and OS (adjusted HR = 1.89, P = .005). Women with pCR showed better EFS (crude HR = 0.15, P < .001) and OS (crude HR = 0.12, P < .001) compared with non-pCR. The ypT ( |
| Document Type: |
article in journal/newspaper |
| Language: |
English |
| Relation: |
https://doi.org/10.1177/1178223420962488; https://doaj.org/toc/1178-2234; https://doaj.org/article/b9b3a008402943d38af4f9b8cd78d46f |
| DOI: |
10.1177/1178223420962488 |
| Availability: |
https://doi.org/10.1177/1178223420962488; https://doaj.org/article/b9b3a008402943d38af4f9b8cd78d46f |
| Accession Number: |
edsbas.7EF215F5 |
| Database: |
BASE |