| Title: |
Type 2-high airway inflammation in childhood asthma distinguishes a more severe phenotype |
| Authors: |
Skov, Frederikke R.; Sultan, Tamo; Fischer-Rasmussen, Kasper; Chawes, Bo L; Stokholm, Jakob; Vahman, Nilo; Bønnelykke, Klaus; Schoos, Ann-Marie M |
| Source: |
Skov , F R , Sultan , T , Fischer-Rasmussen , K , Chawes , B L , Stokholm , J , Vahman , N , Bønnelykke , K & Schoos , A-M M 2025 , ' Type 2-high airway inflammation in childhood asthma distinguishes a more severe phenotype ' , Pediatric Allergy and Immunology, Supplement , vol. 36 , no. 2 , e70032 . https://doi.org/10.1111/pai.70032 |
| Publication Year: |
2025 |
| Collection: |
University of Copenhagen: Research / Forskning ved Københavns Universitet |
| Subject Terms: |
Humans; Asthma/diagnosis; Female; Child; Male; Phenotype; Adolescent; Preschool; Infant; Respiratory Function Tests/methods; Prospective Studies; Newborn; Severity of Illness Index; Th2 Cells/immunology; Lung/physiopathology; Inflammation/diagnosis; Denmark/epidemiology; Bronchial Provocation Tests/methods; Spirometry; Allergens/immunology |
| Description: |
BACKGROUND: It remains unclear whether phenotyping of type 2-high (T2-high) asthma can distinguish clinical characteristics and lung function trajectories in childhood. OBJECTIVE: To explore differences between T2-high and T2-low asthma from birth to age 18 years. METHODS: We included 47 children with asthma and 165 as a control group from the Copenhagen Prospective Studies on Asthma in Childhood2000 mother-child cohort. T2-high and T2-low asthma was defined at age 7 by sensitization to aeroallergens, elevated eosinophilic blood count, and/or elevated fractional nitric oxide. Lung function measurements included whole-body plethysmography, spirometry, exercise test, cold air provocation, and methacholine challenge. Differences in lung function trajectories and traits were analyzed using linear mixed models, Wilcoxon rank-sum test, Fisher's exact test, and Quasi-Poisson regression. RESULTS: At age 7 years, 47 had asthma (26 T2-high, 21 T2-low). By age 18, 12 (46.2%) with T2-high had persistent asthma whereas 2 (9.2%) with T2-low; OR 8.14 [1.57-42.34]. Specific airway resistance (sRaw) was 12.5% higher through childhood in children with T2-high asthma (estimate 0.53 [0.06; 1.01]); lung function was more reversible (OR 3.37 [1.03-11.00] for spirometry and OR 2.60 [1.17; 5.75] for sRaw), and they had increased airway hyperresponsiveness (AHR) to methacholine (as shown by 41% lower dose required to cause a 20% drop in lung function (estimate -0.70 [-1.18; -0.23])). There was no significant difference in exacerbation rate and other lung function measurements. CONCLUSION: Childhood T2-high asthma differs from T2-low asthma in terms of onset, duration, airway resistance, and airway responsiveness. |
| Document Type: |
article in journal/newspaper |
| File Description: |
application/pdf |
| Language: |
English |
| DOI: |
10.1111/pai.70032 |
| Availability: |
https://researchprofiles.ku.dk/da/publications/6fee2a12-3134-476d-a018-4d3d13cd6d82; https://doi.org/10.1111/pai.70032; https://curis.ku.dk/ws/files/424923084/Pediatric_Allergy_Immunology_2025_Skov_Type_2_high_airway_inflammation_in_childhood_asthma_distinguishes_a_more.pdf |
| Rights: |
info:eu-repo/semantics/openAccess |
| Accession Number: |
edsbas.7F06F1F5 |
| Database: |
BASE |