| Title: |
Eculizumab for the Treatment of Severe Antibody-Mediated Rejection: A Case Report and Review of the Literature |
| Authors: |
Tran, Duy; Boucher, Anne; Collette, Suzon; Payette, Alexis; Royal, Virginie; Senécal, Lynne |
| Source: |
Case Reports in Transplantation ; volume 2016, page 1-4 ; ISSN 2090-6943 2090-6951 |
| Publisher Information: |
Wiley |
| Publication Year: |
2016 |
| Collection: |
Wiley Online Library (Open Access Articles via Crossref) |
| Description: |
In renal transplantation, treatment options for antibody-mediated rejection are limited. Here, we report a case of severe AMR treated with eculizumab. A 50-year-old woman known for end stage kidney disease secondary to IgA nephropathy received a kidney transplant from a 50-year-old deceased donor. At 5 months after transplantation, she presented with acute graft dysfunction and biopsy showed a severe antibody-mediated rejection associated with thrombotic microangiopathy. Despite an aggressive conventional immunosuppressive regimen, signs of rejection persisted and the patient was treated with 3 doses of eculizumab. Following the therapy, markers of TMA improved and graft function stabilized. However, ongoing signs of rejection remained in the repeated biopsy. In kidney transplantation, eculizumab is an expensive treatment and its role in the treatment of antibody-mediated rejection remains to be determined. |
| Document Type: |
article in journal/newspaper |
| Language: |
English |
| DOI: |
10.1155/2016/9874261 |
| Availability: |
https://doi.org/10.1155/2016/9874261; http://downloads.hindawi.com/journals/crit/2016/9874261.pdf; http://downloads.hindawi.com/journals/crit/2016/9874261.xml |
| Rights: |
http://creativecommons.org/licenses/by/4.0/ |
| Accession Number: |
edsbas.7F0F9EE4 |
| Database: |
BASE |