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Geo-economic variations in epidemiology, patterns of care, and outcomes in patients with acute respiratory distress syndrome: insights from the LUNG SAFE prospective cohort study

Title:	Geo-economic variations in epidemiology, patterns of care, and outcomes in patients with acute respiratory distress syndrome: insights from the LUNG SAFE prospective cohort study
Authors:	Laffey, John G; Madotto, Fabiana; Bellani, Giacomo; Pham, Tài; Fan, Eddy; Brochard, Laurent; Amin, Pravin; Arabi, Yaseen; Bajwa, Ednan K; Bruhn, Alejandro; Cerny, Vladimir; Clarkson, Kevin; Heunks, Leo; Kurahashi, Kiyoyasu; Laake, Jon Henrik; Lorente, Jose A; McNamee, Lia; Nin, Nicolas; Palo, Jose Emmanuel; Piquilloud, Lise; Qiu, Haibo; Jiménez, Juan Ignacio Silesky; Esteban, Andres; McAuley, Daniel F; van Haren, Frank; Ranieri, Marco; Rubenfeld, Gordon; Wrigge, Hermann; Slutsky, Arthur S; Pesenti, Antonio; Laffey, John G.; Pham, Tai; Gattinoni, Luciano; Larsson, Anders; McAuley, Daniel F.; Thompson, B Taylor; Slutsky, Arthur S.; Rios, Fernando; Sottiaux, Thierry; Depuydt, Pieter; Lora, Fredy S; Azevedo, Luciano C; Bugedo, Guillermo; Gonzalez, Marcos; Silesky, Juan; Nielsen, Jonas; Jibaja, Manuel; Matamis, Dimitrios; Ranero, Jorge L.; Hashemian, S. M.; Villagomez, Asisclo; Zeggwagh, Amine Ali; Heunks, Leo M; Fernandes, Antero do Vale; Sandesc, Dorel; Arabi, Yaasen; Bumbasierevic, Vesna; Lorente, Jose A.; Abroug, Fekri; Hurtado, Javier; Bajwa, Ed; Démpaire, Gabriel; Sula, Hektor; Nunci, Lordian; Cani, Alma; Zazu, Alan; Dellera, Christian; Alejandro, Risso V; Daldin, Julio; Fernandez, Ruben O; Cardonnet, Luis P; Bettini, Lisandro R.; Bisso, Mariano Carboni; Osman, Emilio M.; Setten, Mariano G.; Lovazzano, Pablo; Alvarez, Javier; Villar, Veronica; Pozo, Norberto C.; Grubissich, Nicolas; Plotnikow, Gustavo A.; Vasquez, Daniela N.; Ilutovich, Santiago; Tiribelli, Norberto; Chena, Ariel; Pellegrini, Carlos A.; Saenz, María G.; Estenssoro, Elisa; Brizuela, Matias; Gianinetto, Hernan; Gomez, Pablo E.; Cerrato, Valeria I.; Bezzi, Marco G.; Borello, Silvina A.; Loiacono, Flavia A.; Fernandez, Adriana M.; Knowles, Serena; Reynolds, Claire; Inskip, Deborah M.; Miller, Jennene J; Kong, Jing; Whitehead, Christina; Bihari, Shailesh; Seven, Aylin; Krstevski, Amanda; Rodgers, Helen; Millar, Rebecca; Mckenna, Toni; Bailey, Irene; Hanlon, Gabrielle; Aneman, Anders; Lynch, Joan; Azad, Raman; Neal, John; Woods, Paul; Roberts, Brigit; Kol, Mark; Wong, Helen; Riss, Katharina; Staudinger, Thomas; Wittebole, Xavier; Berghe, Caroline; Bulpa, Pierre; Dive, Alain; Verstraete, Rik; Lebbinck, Herve; Vermassen, Joris; Meersseman, Philippe; Ceunen, Helga; Rosa, Jonas; Beraldo, Daniel; Piras, Claudio; Rampinelli, Adenilton; Nassar, Antonio; Mataloun, Sergio; Moock, Marcelo; Thompson, Marlus; Gonçalves, Claudio; Antônio, Ana; Ascoli, Aline; Biondi, Rodrigo; Fontenele, Danielle; Nobrega, Danielle; Sales, Vanessa; Shindhe, Suresh; Ismail, Dk; Beloncle, Francois; Davies, Kyle; Cirone, Rob; Manoharan, Venika; Ismail, Mehvish; Goligher, Ewan; Jassal, Mandeep; Nishikawa, Erin; Javeed, Areej; Curley, Gerard; Rittayamai, Nuttapol; Parotto, Matteo; Ferguson, Niall; Mehta, Sangeeta; Knoll, Jenny; Pronovost, Antoine; Canestrini, Sergio; Garcia, Patricio; Aliaga, Felipe; Farías, Pamela; Yumha, Jacob; Ortiz, Claudia; Salas, Javier; Saez, Alejandro; Vega, Luis; Labarca, Eduardo; Martinez, Felipe; Carreño, Nicolás; Lora, Pilar; Liu, Haitao; Liu, Ling; Tang, Rui; Luo, Xiaoming; An, Youzhong; Zhao, Huiying; Gao, Yan; Zhai, Zhe; Ye, Zheng; Wang, Wei; Li, Wenwen; Li, Qingdong; Zheng, Ruiqiang; Yu, Wenkui; Shen, Juanhong; Li, Xinyu; Yu, Tao; Lu, Weihua; Wu, Ya; Huang, Xiao; He, Zhenyang; Lu, Yuanhua; Han, Hui; Zhang, Fan; Sun, Renhua; Wang, Hua; Qin, Shu; Zhu, Bao; Zhao, Jun; Liu, Jian; Li, Bin; Liu, Jing; Zhou, Fa; Li, Qiong; Zhang, Xing; Li-Xin, Zhou; Xin-Hua, Qiang; Jiang, Liangyan; Gao, Yuan; Zhao, Xian; Li, Yuan; Li, Xiao; Wang, Chunting; Yao, Qingchun; Yu, Rongguo; Chen, Kai; Shao, Huanzhang; Qin, Bingyu; Huang, Qing; Zhu, Wei; Hang, Ai; Hua, Ma; Li, Yimin; Xu, Yonghao; Di, Yu; Ling, Long; Qin, Tie; Wang, Shou; Qin, Junping; Han, Yi; Zhou, Suming; Vargas, Monica; Jimenez, Juan; Rojas, Manuel; Solis-Quesada, Jaime; Ramirez-Alfaro, Christian; Máca, Jan; Sklienka, Peter; Gjedsted, Jakob; Christiansen, Aage; Villamagua, Boris; Llano, Miguel; Burtin, Philippe; Buzancais, Gautier; Beuret, Pascal; Pelletier, Nicolas; Mortaza, Satar; Mercat, Alain; Chelly, Jonathan; Jochmans, Sébastien; Terzi, Nicolas; Daubin, Cédric; Carteaux, Guillaume; de Prost, Nicolas; Chiche, Jean-Daniel; Daviaud, Fabrice; Fartoukh, Muriel; Barberet, Guillaume; Biehler, Jerome; Dellamonica, Jean; Doyen, Denis; Arnal, Jean-Michel; Briquet, Anais; Hraiech, Sami; Papazian, Laurent; Roux, Damien; Messika, Jonathan; Kalaitzis, Evangelos; Dangers, Laurence; Combes, Alain; Au, Siu-Ming; Béduneau, Gaetan; Carpentier, Dorothée; Zogheib, Elie; Dupont, Herve; Ricome, Sylvie; Santoli, Francesco; Besset, Sebastien; Michel, Philippe; Gelée, Bruno; Danin, Pierre-Eric; Goubaux, Bernard; Crova, Philippe; Phan, Nga; Berkelmans, Frantz; Badie, Julio; Tapponnier, Romain; Gally, Josette; Khebbeb, Samy; Herbrecht, Jean-Etienne; Schneider, Francis; Declercq, Pierre-Louis; Rigaud, Jean-Philippe; Duranteau, Jacques; Harrois, Anatole; Chabanne, Russell; Marin, Julien; Bigot, Charlene; Thibault, Sandrine; Ghazi, Mohammed; Boukhazna, Messabi; Zein, Salem; Richecoeur, Jack; Combaux, Daniele; Grelon, Fabien; Le Moal, Charlene; Sauvadet, Elise; Robine, Adrien; Lemiale, Virginie; Reuter, Danielle; Dres, Martin; Demoule, Alexandre; Goldgran-Toledano, Dany; Baboi, Loredana; Guérin, Claude; Lohner, Ralph; Kraßler, Jens; Schäfer, Susanne; Zacharowski, Kai; Meybohm, Patrick; Reske, Andreas; Simon, Philipp; Hopf, Hans-Bernd; Schuetz, Michael; Baltus, Thomas; Papanikolaou, Metaxia; Papavasilopoulou, Theonymfi; Zacharas, Giannis; Ourailogloy, Vasilis; Mouloudi, Eleni; Massa, Eleni; Nagy, Eva; Stamou, Electra; Kiourtzieva, Ellada; Oikonomou, Marina; Avila, Luis; Cortez, Cesar; Citalán, Johanna; Jog, Sameer; Sable, Safal; Shah, Bhagyesh; Gurjar, Mohan; Baronia, Arvind; Memon, Mohammedfaruk; Muthuchellappan, Radhakrishnan; Ramesh, Venkatapura; Shenoy, Anitha; Unnikrishnan, Ramesh; Dixit, Subhal; Rhayakar, Rachana; Ramakrishnan, Nagarajan; Bhardwaj, Vallish; Mahto, Heera; Sagar, Sudha; Palaniswamy, Vijayanand; Ganesan, Deeban; Hashemian, Seyed; Jamaati, Hamidreza; Heidari, Farshad; Meaney, Edel; Nichol, Alistair; Knapman, Karl; O'Croinin, Donall; Dunne, Eimhin; Breen, Dorothy; Jaafar, Rola; Dwyer, Rory; Amir, Fahd; Ajetunmobi, Olaitan; O'Muircheartaigh, Aogan; Black, Colin; Treanor, Nuala; Collins, Daniel; Altaf, Wahid; Zani, Gianluca; Fusari, Maurizio; Spadaro, Savino; Volta, Carlo; Graziani, Romano; Brunettini, Barbara; Palmese, Salvatore; Formenti, Paolo; Umbrello, Michele; Lombardo, Andrea; Pecci, Elisabetta; Botteri, Marc; Savioli, Monica; Protti, Alessandro; Mattei, Alessia; Schiavoni, Lorenzo; Tinnirello, Andrea; Todeschini, Manuel; Giarratano, Antonino; Cortegiani, Andrea; Sher, Sara; Rossi, Anna; Antonelli, Massimo; Montini, Luca; Casalena, Paolo; Scafetti, Sergio; Panarello, Giovanna; Occhipinti, Giovanna; Patroniti, Nicolò; Pozzi, Matteo; Biscione, Roberto; Poli, Michela; Raimondi, Ferdinando; Albiero, Daniela; Crapelli, Giulia; Beck, Eduardo; Pota, Vincenzo; Schiavone, Vincenzo; Molin, Alexandre; Tarantino, Fabio; Monti, Giacomo; Frati, Elena; Mirabella, Lucia; Cinnella, Gilda; Fossali, Tommaso; Colombo, Riccardo; Terragni, Pierpaolo; Pattarino, Ilaria; Mojoli, Francesco; Braschi, Antonio; Borotto, Erika; Cracchiolo, Andrea; Palma, Daniela; Raponi, Francesco; Foti, Giuseppe; Vascotto, Ettore; Coppadoro, Andrea; Brazzi, Luca; Floris, Leda; Iotti, Giorgio; Venti, Aaron; Yamaguchi, Osamu; Takagi, Shunsuke; Maeyama, Hiroki; Watanabe, Eizo; Yamaji, Yoshihiro; Shimizu, Kazuyoshi; Shiozaki, Kyoko; Futami, Satoru; Ryosuke, Sekine; Saito, Koji; Kameyama, Yoshinobu; Ueno, Keiko; Izawa, Masayo; Okuda, Nao; Suzuki, Hiroyuki; Harasawa, Tomofumi; Nasu, Michitaka; Takada, Tadaaki; Ito, Fumihito; Nunomiya, Shin; Koyama, Kansuke; Abe, Toshikazu; Andoh, Kohkichi; Kusumoto, Kohei; Hirata, Akira; Takaba, Akihiro; Kimura, Hiroyasu; Matsumoto, Shuhei; Higashijima, Ushio; Honda, Hiroyuki; Aoki, Nobumasa; Imai, Hiroshi; Ogino, Yasuaki; Mizuguchi, Ichiko; Ichikado, Kazuya; Nitta, Kenichi; Mochizuki, Katsunori; Hashida, Tomoaki; Tanaka, Hiroyuki; Nakamura, Tomoyuki; Niimi, Daisuke; Ueda, Takeshi; Kashiwa, Yozo; Uchiyama, Akinori; Sabelnikovs, Olegs; Oss, Peteris; Haddad, Youssef; Liew, Kong; Ñamendys-Silva, Silvio; Jarquin-Badiola, Yves; Sanchez-Hurtado, Luis; Gomez-Flores, Saira; Marin, Maria; Lemus, Jordana; Fierro, Jonathan; Cervantes, Mavy; Mejia, Francisco; Dector, Dulce M.; Gonzalez, Daniel; Estrella, Claudia; Sanchez-Medina, Jorge; Ramirez-Gutierrez, Alvaro; George, Fernando; Aguirre, Janet; Buensuseso, Juan; Poblano, Manuel; Dendane, Tarek; Zeggwagh, Amine; Balkhi, Hicham; Elkhayari, Mina; Samkaoui, Nacer; Ezzouine, Hanane; Benslama, Abdellatif; Amor, Mourad; Maazouzi, Wajdi; Cimic, Nedim; Beck, Oliver; Bruns, Monique; Schouten, Jeroen; Rinia, Myra; Raaijmakers, Monique; Van Wezel, Hellen; Heines, Serge; Strauch, Ulrich; Simonis, Fabienne; Goodson, Jennifer; Browne, Troy; Navarra, Leanlove; Hunt, Anna; Hutchison, Robyn; Bailey, Mathew; Newby, Lynette; Mcarthur, Colin; Kalkoff, Michael; Mcleod, Alex; Casement, Jonathan; Hacking, Danielle; Andersen, Finn; Dolva, Merete; Laake, Jon; Barratt-Due, Andreas; Noremark, Kim; Søreide, Eldar; Sjøbø, Brit; Guttormsen, Anne; Yoshido, Hector; Aguilar, Ronald; Oscanoa, Fredy; Alisasis, Alain; Robles, Joanne; Pasanting-Lim, Rossini; Tan, Beatriz; Andruszkiewicz, Pawel; Jakubowska, Karina; Coxo, Cristina; Alvarez, António; Oliveira, Bruno; Montanha, Gustavo; Barros, Nelson; Pereira, Carlos; Messias, António; Monteiro, Jorge; Araujo, Ana; Catorze, Nuno; Marum, Susan; Bouw, Maria; Gomes, Rui; Brito, Vania; Castro, Silvia; Estilita, Joana; Barros, Filipa; Serra, Isabel; Martinho, Aurelia; Tomescu, Dana; Marcu, Alexandra; Bedreag, Ovidiu; Papurica, Marius; Corneci, Dan; Negoita, Silvius; Grigoriev, Evgeny; Gritsan, Alexey; Gazenkampf, Andrey; Almekhlafi, Ghaleb; Albarrak, Mohamad; Mustafa, Ghanem; Maghrabi, Khalid; Salahuddin, Nawal; Aisa, Tharwat; Al Jabbary, Ahmed; Tabhan, Edgardo; Trinidad, Olivia; Al Dorzi, Hasan; Bolon, Stefan; Smith, Oliver; Mancebo, Jordi; Aguirre-Bermeo, Hernan; Lopez-Delgado, Juan; Esteve, Francisco; Rialp, Gemma; Forteza, Catalina; De Haro, Candelaria; Albaiceta, Guillermo; De Cima-Iglesias, Sara; Seoane-Quiroga, Leticia; Ceniceros-Barros, Alexandra; Ruiz-Aguilar, Antonio; Claraco-Vega, Luis; Soler, Juan; del Carmen Lorente, Maria; Hermosa, Cecilia; Gordo, Federico; Prieto-González, Miryam; López-Messa, Juan; Perez, Manuel; Perez, Cesar; Allue, Raquel; Roche-Campo, Ferran; Ibañez-Santacruz, Marcos; Temprano, Susana; Pintado, Maria; De Pablo, Raul; Gómez, Pilar; Ruiz, Silvia; Moles, Silvia; Jurado, Teresa; Arizmendi, Alfons; Piacentini, Enrique; Franco, Nieves; Honrubia, Teresa; Cheng, Meisy; Losada, Elena; Blanco, Javier; Yuste, Luis; Carbayo-Gorriz, Cecilia; Cazorla-Barranquero, Francisca; Alonso, Javier; Alda, Rosa; Algaba, Ángela; Navarro, Gonzalo; Cereijo, Enrique; Diaz-Rodriguez, Esther; Marcos, Diego; Montero, Laura; Para, Luis; Sanchez, Roberto; Navalpotro, Miguel; Abad, Ricardo; González, Raquel; Toribio, Dácil; Castro, Alejandro; Artiga, Maria; Penuelas, Oscar; Roser, Tomas; Olga, Moreno; Curto, Elena; Sánchez, Rocío; Imma, Vallverdu; Elisabet, Garcia; Claverias, Laura; Magret, Monica; Pellicer, Ana; Rodriguez, Lucia; Sánchez-Ballesteros, Jesús; González-Salamanca, Ángela; Jimenez, Antonio; Huerta, Francisco; Diaz, Juan; Lopez, Esther; Moya, David; Alfonso, Alec; Luis, Palazon; Cesar, Palazon; Rafael, Sánchez; Virgilio, Corcoles; Recio, Noelia; Adamsson, Richard; Rylander, Christian; Holzgraefe, Bernhard; Broman, Lars; Wessbergh, Joanna; Persson, Linnea; Schiöler, Fredrik; Kedelv, Hans; Tibblin, Anna; Appelberg, Henrik; Hedlund, Lars; Helleberg, Johan; Eriksson, Karin; Glietsch, Rita; Larsson, Niklas; Nygren, Ingela; Nunes, Silvia; Morin, Anna-Karin; Kander, Thomas; Adolfsson, Anne; Zender, Hervé; Leemann-Refondini, Corinne; Elatrous, Souheil; Bouchoucha, Slaheddine; Chouchene, Imed; Ouanes, Islem; Souissi, Asma; Kamoun, Salma; Demirkiran, Oktay; Aker, Mustafa; Erbabacan, Emre; Ceylan, Ilkay; Girgin, Nermin; Ozcelik, Menekse; Ünal, Necmettin; Meco, Basak; Akyol, Onat; Derman, Suleyman; Kennedy, Barry; Parhar, Ken; Srinivasa, Latha; McAuley, Danny; Hopkins, Phil; Mellis, Clare; Kakar, Vivek; Hadfield, Dan; Vercueil, Andre; Bhowmick, Kaushik; Humphreys, Sally; Ferguson, Andrew; Mckee, Raymond; Raj, Ashok; Fawkes, Danielle; Watt, Philip; Twohey, Linda; Jha, Rajeev; Thomas, Matthew; Morton, Alex; Kadaba, Varsha; Smith, Mark; Hormis, Anil; Kannan, Santhana; Namih, Miriam; Reschreiter, Henrik; Camsooksai, Julie; Kumar, Alek; Rugonfalvi, Szabolcs; Nutt, Christopher; O'Neill, Orla; Seasman, Colette; Dempsey, Ged; Scott, Christopher; Ellis, Helen; MckKechnie, Stuart; Hutton, Paula; Di Tomasso, Nora; Vitale, Michela; Griffin, Ruth; Dean, Michael; Cranshaw, Julius; Willett, Emma; Ioannou, Nicholas; Gillis, Sarah; Csabi, Peter; Macfadyen, Rosaleen; Dawson, Heidi; Preez, Pieter; Williams, Alexandra; Boyd, Owen; De Gordoa, Laura; Bramall, Jon; Symmonds, Sophie; Chau, Simon; Wenham, Tim; Szakmany, Tamas; Toth-Tarsoly, Piroska; McCalman, Katie; Alexander, Peter; Stephenson, Lorraine; Collyer, Thomas; Chapman, Rhiannon; Cooper, Raphael; Allan, Russell; Sim, Malcolm; Wrathall, David; Irvine, Donald; Zantua, Kim; Adams, John; Burtenshaw, Andrew; Sellors, Gareth; Welters, Ingeborg; Williams, Karen; Hessell, Robert; Oldroyd, Matthew; Battle, Ceri; Pillai, Suresh; Kajtor, Istvan; Sivashanmugavel, Mageswaran; O'Kane, Sinead; Donnelly, Adrian; Frigyik, Aniko; Careless, Jon; May, Martin; Stewart, Richard; Trinder, T. John; Hagan, Samantha; Wise, Matt; Cole, Jade; MacFie, Caroline; Dowling, Anna; Nin, Nicolás; Nuñez, Edgardo; Pittini, Gustavo; Rodriguez, Ruben; Imperio, María; Santos, Cristina; França, Ana; Ebeid, Alejandro; Deicas, Alberto; Serra, Carolina; Uppalapati, Aditya; Kamel, Ghassan; Banner-Goodspeed, Valerie; Beitler, Jeremy; Mukkera, Satyanarayana; Kulkarni, Shreedhar; Lee, Jarone; Mesar, Tomaz; Shinn, John; Gomaa, Dina; Tainter, Christopher; Yeatts, Dale; Warren, Jessica; Lanspa, Michael; Miller, Russel; Grissom, Colin; Brown, Samuel; Bauer, Philippe; Gosselin, Ryan; Kitch, Barrett; Cohen, Jason; Beegle, Scott; Gueret, Renaud; Tulaimat, Aiman; Choudry, Shazia; Stigler, William; Batra, Hitesh; Huff, Nidhi; Lamb, Keith; Oetting, Trevor; Mohr, Nicholas; Judy, Claine; Saito, Shigeki; Kheir, Fayez; Schlichting, Adam; Delsing, Angela; Crouch, Daniel; Elmasri, Mary; Ismail, Dina; Dreyer, Kyle; Blakeman, Thomas; Baron, Rebecca; Grijalba, Carolina; Hou, Peter; Seethala, Raghu; Aisiku, Imo; Henderson, Galen; Hou, Sen-Kuang; Owens, Robert; Schomer, Ashley; Bumbasirevic, Vesna; Jovanovic, Bojan; Surbatovic, Maja; Veljovic, Milic
Contributors:	Laffey, John G; Madotto, Fabiana; Bellani, Giacomo; Pham, Tài; Fan, Eddy; Brochard, Laurent; Amin, Pravin; Arabi, Yaseen; Bajwa, Ednan K; Bruhn, Alejandro; Cerny, Vladimir; Clarkson, Kevin; Heunks, Leo; Kurahashi, Kiyoyasu; Laake, Jon Henrik; Lorente, Jose A; Mcnamee, Lia; Nin, Nicola; Palo, Jose Emmanuel; Piquilloud, Lise; Qiu, Haibo; Jiménez, Juan Ignacio Silesky; Esteban, Andre; Mcauley, Daniel F; van Haren, Frank; Ranieri, Marco; Rubenfeld, Gordon; Wrigge, Hermann; Slutsky, Arthur S; Pesenti, Antonio; Laffey, John G.; Pham, Tai; Gattinoni, Luciano; Larsson, Ander; Mcauley, Daniel F.; Thompson, B Taylor; Slutsky, Arthur S.; Rios, Fernando; Sottiaux, Thierry; Depuydt, Pieter; Lora, Fredy S; Azevedo, Luciano C; Bugedo, Guillermo; Gonzalez, Marco; Silesky, Juan; Nielsen, Jona; Jibaja, Manuel; Matamis, Dimitrio; Ranero, Jorge L.; Hashemian, S. M.; Villagomez, Asisclo; Zeggwagh, Amine Ali; Heunks, Leo M; Fernandes, Antero do Vale; Sandesc, Dorel; Arabi, Yaasen; Bumbasierevic, Vesna; Lorente, Jose A.; Abroug, Fekri; Hurtado, Javier; Bajwa, Ed; Démpaire, Gabriel; Sula, Hektor; Nunci, Lordian; Cani, Alma; Zazu, Alan; Dellera, Christian; Alejandro, Risso V; Daldin, Julio; Fernandez, Ruben O; Cardonnet, Luis P; Bettini, Lisandro R.; Bisso, Mariano Carboni; Osman, Emilio M.; Setten, Mariano G.; Lovazzano, Pablo; Alvarez, Javier; Villar, Veronica; Pozo, Norberto C.
Publication Year:	2017
Description:	Background Little information is available about the geo-economic variations in demographics, management, and outcomes of patients with acute respiratory distress syndrome (ARDS). We aimed to characterise the effect of these geo-economic variations in patients enrolled in the Large Observational Study to Understand the Global Impact of Severe Acute Respiratory Failure (LUNG SAFE).Methods LUNG SAFE was done during 4 consecutive weeks in winter, 2014, in a convenience sample of 459 intensive-care units in 50 countries across six continents. Inclusion criteria were admission to a participating intensive-care unit (including transfers) within the enrolment window and receipt of invasive or non-invasive ventilation. One of the trial's secondary aims was to characterise variations in the demographics, management, and outcome of patients with ARDS. We used the 2016 World Bank countries classification to define three major geo-economic groupings, namely European high-income countries (Europe-High), high-income countries in the rest of the world (rWORLD-High), and middle-income countries (Middle). We compared patient outcomes across these three groupings. LUNG SAFE is registered with ClinicalTrials.gov, number NCT02010073.Findings Of the 2813 patients enrolled in LUNG SAFE who fulfilled ARDS criteria on day 1 or 2, 1521 (54%) were recruited from Europe-High, 746 (27%) from rWORLD-High, and 546 (19%) from Middle countries. We noted significant geographical variations in demographics, risk factors for ARDS, and comorbid diseases. The proportion of patients with severe ARDS or with ratios of the partial pressure of arterial oxygen (PaO2) to the fractional concentration of oxygen in inspired air (FIO2) less than 150 was significantly lower in rWORLD-High countries than in the two other regions. Use of prone positioning and neuromuscular blockade was significantly more common in Europe-High countries than in the other two regions. Adjusted duration of invasive mechanical ventilation and length of stay in the intensive-care ...
Document Type:	article in journal/newspaper
Language:	English
Relation:	info:eu-repo/semantics/altIdentifier/wos/WOS:000406042400020; volume:5; issue:8; firstpage:627; lastpage:638; numberofpages:12; journal:THE LANCET RESPIRATORY MEDICINE; https://hdl.handle.net/11388/328314
DOI:	10.1016/s2213-2600(17)30213-8
Availability:	https://hdl.handle.net/11388/328314; https://doi.org/10.1016/s2213-2600(17)30213-8
Accession Number:	edsbas.7F16367B
Database:	BASE