| Title: |
Differential cellular proliferation underlies heterochronic generation of cranial diversity in phyllostomid bats |
| Authors: |
Camacho, J; Moon, R; Smith, SK; Lin, JD; Randolph, C; Rasweiler, JJ; Behringer, RR; Abzhanov, A |
| Contributors: |
Human Frontier Science Program; Commission of the European Communities |
| Publisher Information: |
BioMed Central |
| Publication Year: |
2020 |
| Collection: |
Imperial College London: Spiral |
| Subject Terms: |
Science & Technology; Life Sciences & Biomedicine; Evolutionary Biology; Developmental Biology; Development; Evolution; Heterochrony; Cell proliferation; Craniofacial; Morphology; Bat; EMBRYONIC STAGING SYSTEM; HISTONE H3; CHIROPTERA; MODULARITY; DIVERSIFICATION; INTEGRATION; OUTGROWTH; ONTOGENY; BIOLOGY; 0601 Biochemistry and Cell Biology; 0603 Evolutionary Biology |
| Description: |
Background Skull diversity in the neotropical leaf-nosed bats (Phyllostomidae) evolved through a heterochronic process called peramorphosis, with underlying causes varying by subfamily. The nectar-eating (subfamily Glossophaginae) and blood-eating (subfamily Desmondontinae) groups originate from insect-eating ancestors and generate their uniquely shaped faces and skulls by extending the ancestral ontogenetic program, appending new developmental stages and demonstrating peramorphosis by hypermorphosis. However, the fruit-eating phyllostomids (subfamilies Carollinae and Stenodermatinae) adjust their craniofacial development by speeding up certain developmental processes, displaying peramorphosis by acceleration. We hypothesized that these two forms of peramorphosis detected by our morphometric studies could be explained by differential growth and investigated cell proliferation during craniofacial morphogenesis. Results We obtained cranial tissues from four wild-caught bat species representing a range of facial diversity and labeled mitotic cells using immunohistochemistry. During craniofacial development, all bats display a conserved spatiotemporal distribution of proliferative cells with distinguishable zones of elevated mitosis. These areas were identified as modules by the spatial distribution analysis. Ancestral state reconstruction of proliferation rates and patterns in the facial module between species provided support, and a degree of explanation, for the developmental mechanisms underlying the two models of peramorphosis. In the long-faced species, Glossophaga soricina, whose facial shape evolved by hypermorphosis, cell proliferation rate is maintained at lower levels and for a longer period of time compared to the outgroup species Miniopterus natalensis. In both species of studied short-faced fruit bats, Carollia perspicillata and Artibeus jamaicensis, which evolved under the acceleration model, cell proliferation rate is increased compared to the outgroup. Conclusions This is the first study which links ... |
| Document Type: |
article in journal/newspaper |
| Language: |
English |
| Relation: |
EvoDevo; http://hdl.handle.net/10044/1/91773; RGP039/2019; 702707; RGP0039/2019 |
| DOI: |
10.1186/s13227-020-00156-9 |
| Availability: |
http://hdl.handle.net/10044/1/91773; https://doi.org/10.1186/s13227-020-00156-9 |
| Rights: |
© 2020 The Author(s). This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data. ; http://creativecommons.org/licenses/by/4.0/ |
| Accession Number: |
edsbas.7F3B929A |
| Database: |
BASE |