| Title: |
An HLA-G/SPAG9/STAT3 axis promotes brain metastases |
| Authors: |
Bassey-Archibong, Blessing Iquo; Rajendra Chokshi, Chirayu; Aghaei, Nikoo; Kieliszek, Agata Monika; Tatari, Nazanin; McKenna, Dillon; Singh, Mohini; Kalpana Subapanditha, Minomi; Parmar, Arun; Mobilio, Daniel; Savage, Neil; Lam, Fred; Tokar, Tomas; Provias, John; Lu, Yu; Chafe, Shawn Christopher; Swanton, Charles; Hynds, Robert Edward; Venugopal, Chitra; Singh, Sheila Kumari |
| Source: |
Proceedings of the National Academy of Sciences (PNAS) , 120 (8) , Article e2205247120. (2023) |
| Publisher Information: |
Proceedings of the National Academy of Sciences |
| Publication Year: |
2023 |
| Collection: |
University College London: UCL Discovery |
| Subject Terms: |
HLA-G; SPAG9; STAT3; brain metastases; Adult; Humans; HLA-G Antigens; Brain Neoplasms; Lung; Brain; Melanoma; Lung Neoplasms; Adaptor Proteins; Signal Transducing; STAT3 Transcription Factor |
| Description: |
Brain metastases (BM) are the most common brain neoplasm in adults. Current BM therapies still offer limited efficacy and reduced survival outcomes, emphasizing the need for a better understanding of the disease. Herein, we analyzed the transcriptional profile of brain metastasis initiating cells (BMICs) at two distinct stages of the brain metastatic cascade-the "premetastatic" or early stage when they first colonize the brain and the established macrometastatic stage. RNA sequencing was used to obtain the transcriptional profiles of premetastatic and macrometastatic (non-premetastatic) lung, breast, and melanoma BMICs. We identified that lung, breast, and melanoma premetastatic BMICs share a common transcriptomic signature that is distinct from their non-premetastatic counterparts. Importantly, we show that premetastatic BMICs exhibit increased expression of HLA-G, which we further demonstrate functions in an HLA-G/SPAG9/STAT3 axis to promote the establishment of brain metastatic lesions. Our findings suggest that unraveling the molecular landscape of premetastatic BMICs allows for the identification of clinically relevant targets that can possibly inform the development of preventive and/or more efficacious BM therapies. |
| Document Type: |
article in journal/newspaper |
| File Description: |
text |
| Language: |
English |
| Relation: |
https://discovery.ucl.ac.uk/id/eprint/10165283/1/pnas.2205247120.pdf; https://discovery.ucl.ac.uk/id/eprint/10165283/ |
| Availability: |
https://discovery.ucl.ac.uk/id/eprint/10165283/1/pnas.2205247120.pdf; https://discovery.ucl.ac.uk/id/eprint/10165283/ |
| Rights: |
open |
| Accession Number: |
edsbas.7F4B6E40 |
| Database: |
BASE |