| Title: |
Apolipoprotein C-III Levels and Incident Coronary Artery Disease Risk: The EPIC-Norfolk Prospective Population Study. |
| Authors: |
van Capelleveen, JC; Bernelot Moens, SJ; Yang, X; Kastelein, JJP; Wareham, NJ; Zwinderman, AH; Stroes, ESG; Witztum, JL; Hovingh, GK; Khaw, K-T; Boekholdt, SM; Tsimikas, S |
| Publisher Information: |
American Heart Association; //doi.org/10.1161/atvbaha.117.309007 |
| Publication Year: |
2017 |
| Collection: |
Apollo - University of Cambridge Repository |
| Subject Terms: |
C-reactive protein; apolipoprotein CIII; coronary artery disease; lipoproteins; triglycerides |
| Description: |
$\textbf{Objective-}$Apolipoprotein C-III (apoC-III) is a key regulator of triglyceride metabolism. Elevated triglyceride-rich lipoproteins and apoC-III levels are causally linked to coronary artery disease (CAD) risk. The mechanism(s) through which apoC-III increases CAD risk remains largely unknown. The aim was to confirm the association between apoC-III plasma levels and CAD risk and to explore which lipoprotein subfractions contribute to this relationship between apoC-III and CAD risk. $\textbf{Approach and Results-}$Plasma apoC-III levels were measured in baseline samples from a nested case-control study in the European Prospective Investigation of Cancer (EPIC)-Norfolk study. The study comprised 2711 apparently healthy study participants, of whom 832 subsequently developed CAD. We studied the association of baseline apoC-III levels with incident CAD risk, lipoprotein subfractions measured by nuclear magnetic resonance spectroscopy and inflammatory biomarkers. ApoC-III levels were significantly associated with CAD risk (odds ratio, 1.91; 95% confidence interval, 1.48-2.48 for highest compared with lowest quintile), retaining significance after adjustment for traditional CAD risk factors (odds ratio, 1.47; 95% confidence interval, 1.11-1.94). ApoC-III levels were positively correlated with triglyceride levels, (r=0.39), particle numbers of very-low-density lipoprotein (r=0.25), intermediate-density lipoprotein (r=0.23), small dense low-density lipoprotein (r=0.26), and high-sensitivity C-reactive protein (r=0.15), whereas an inverse correlation was observed with large low-density lipoprotein particle number (r=-0.11), P |
| Document Type: |
article in journal/newspaper |
| File Description: |
application/vnd.openxmlformats-officedocument.wordprocessingml.document |
| Language: |
English |
| Relation: |
https://www.repository.cam.ac.uk/handle/1810/265194 |
| DOI: |
10.17863/CAM.10741 |
| Availability: |
https://www.repository.cam.ac.uk/handle/1810/265194; https://doi.org/10.17863/CAM.10741 |
| Rights: |
All rights reserved ; http://purl.org/NET/rdflicense/allrightsreserved |
| Accession Number: |
edsbas.7F967A39 |
| Database: |
BASE |