| Title: |
FSH response-dose can be predicted in ovulation induction for normogonadotropic anovulatory infertility |
| Authors: |
van Santbrink, EJ; Eijkemans, MJ; Macklon, NS; Fauser, BC |
| Source: |
European Journal of Endocrinology ; page 223-226 ; ISSN 0804-4643 1479-683X |
| Publisher Information: |
Oxford University Press (OUP) |
| Publication Year: |
2002 |
| Description: |
OBJECTIVE: To evaluate the ability of a prediction model to identify the individual starting dose of FSH for ovulation induction using a step-down regimen. DESIGN: Retrospective analysis of clinical data in an academic fertility unit. Fifty-six normogonadotropic anovulatory infertile patients who failed to ovulate or conceive with clomiphene citrate were included. They were treated with exogenous gonadotropins with a flexible starting dose for ovulation induction using a step-down regimen. The clinically applied starting dose of exogenous gonadotropins was compared with the calculated response-dose using a previously published prediction model. RESULTS: Patients were arbitrarily divided into three groups according to the day of the first decrease in gonadotropin dose: (a) early step-down (day 3 or earlier); (b) standard step-down (day 4 or later); (c) no step-down. These groups had average starting doses of 28.5 IU (group a) and 13 IU (group b) above the calculated response-dose, and 43 IU (group c) under the calculated response-dose. A significant correlation between day of first step-down and the difference between clinically applied and calculated response-dose was observed (P |
| Document Type: |
article in journal/newspaper |
| Language: |
unknown |
| DOI: |
10.1530/eje.0.1470223 |
| Availability: |
https://doi.org/10.1530/eje.0.1470223; https://eje.bioscientifica.com/view/journals/eje/147/2/223.xml |
| Accession Number: |
edsbas.7FA028EB |
| Database: |
BASE |