| Title: |
Closed-loop auditory stimulation method to modulate sleep slow waves and motor learning performance in rats |
| Authors: |
Moreira, Carlos G; Baumann, Christian R; Scandella, Maurizio; Nemirovsky, Sergio I; Leach, Sven; Huber, Reto; Noain, Daniela |
| Source: |
Moreira, Carlos G; Baumann, Christian R; Scandella, Maurizio; Nemirovsky, Sergio I; Leach, Sven; Huber, Reto; Noain, Daniela (2021). Closed-loop auditory stimulation method to modulate sleep slow waves and motor learning performance in rats. bioRxiv 435881, Cold Spring Harbor Laboratory. |
| Publication Year: |
2021 |
| Collection: |
University of Zurich (UZH): ZORA (Zurich Open Repository and Archive |
| Subject Terms: |
Medical Clinic; Clinic for Neurology; Child and Adolescent Psychiatry; Neuroscience Center Zurich; 610 Medicine & health; Closed-loop auditory stimulation; sleep slow waves; motor learning; sleep modulation |
| Description: |
Slow waves and cognitive output have been modulated in humans by phase-targeted auditory stimulation. However, to advance its technical development and further our understanding, implementation of the method in animal models is indispensable. Here, we report the successful employment of slow waves’ phase-targeted closed-loop auditory stimulation (CLAS) in rats. To validate this new tool both conceptually and functionally, we tested the effects of up- and down-phase CLAS on proportions and spectral characteristics of sleep, and on learning performance in the single pellet-reaching task, respectively. Without affecting 24-h sleep-wake behavior, CLAS specifically altered delta (slow waves) and sigma (sleep spindles) power persistently over chronic periods of stimulation. Down-phase CLAS exerted a detrimental effect on overall engagement and success rate in the behavioral test, and overall CLAS-dependent spectral changes were positively correlated with learning performance. Altogether, our results provide proof-of-principle evidence that phase-targeted CLAS of slow waves in rodents is efficient, safe and stable over chronic experimental periods, enabling the use of this high-specificity tool for basic and preclinical translational sleep research. |
| Document Type: |
report |
| File Description: |
application/pdf |
| Language: |
English |
| ISSN: |
2164-7844 |
| Relation: |
https://www.zora.uzh.ch/id/eprint/216457/1/Moreira_et_al_2021_Closed-loop_auditory_stimulation_method_to_modulate_sleep_slow_waves_and_motor_learning_performance_in_rats_preprint_bioRxiv.pdf; urn:issn:2164-7844 |
| DOI: |
10.1101/2021.03.17.435881 |
| Availability: |
https://www.zora.uzh.ch/id/eprint/216457/; https://doi.org/10.1101/2021.03.17.435881 |
| Rights: |
info:eu-repo/semantics/openAccess ; Creative Commons: Attribution 4.0 International (CC BY 4.0) ; http://creativecommons.org/licenses/by/4.0/ |
| Accession Number: |
edsbas.805C79EC |
| Database: |
BASE |