| Title: |
Safety and effectiveness of do-it-yourself artificial pancreas system compared with continuous subcutaneous insulin infusions in combination with free style libre in people with type 1 diabetes |
| Authors: |
Patel, Rachel; Crabtree, Thomas S.J.; Taylor, Nicola; Langeland, Linn; Gazis, Anastasios (Tasso); Mendis, Buddhike; Wilmot, Emma G.; Idris, Iskandar |
| Publisher Information: |
Wiley |
| Publication Year: |
2022 |
| Collection: |
University of Nottingham: Repository@Nottingham |
| Subject Terms: |
Endocrinology; Diabetes and Metabolism; Internal Medicine |
| Description: |
Aims: The use of do-it-yourself artificial pancreas systems (DIYAPS) among people with type 1 diabetes is increasing. At present, it is unclear how DIYAPS compares with other technologies such as FreeStyle Libre (FSL) and continuous subcutaneous insulin infusion (CSII). The aim of this analysis is to compare safety, effectiveness and quality-of-life outcomes of DIYAPS use with the addition of FSL to CSII. Method: Data from two large UK hospitals were extracted from the Association of British Clinical Diabetologists (ABCD) DIYAPS and FSL audits. Outcomes included HbA1c, glucose TBR (time-below-range), TIR (time-in-range), Diabetes Distress Score (DDS), and Gold hypoglycaemia score. Any adverse events were noted. Changes at follow-up were assessed using paired t-tests and ANOVA in Stata; TIR/TBR at follow-up assessed using unpaired t-tests; chi-square tests assessed the change in frequency of health utilisation (e.g. hospital admissions). Results: DIYAPS (n=35) and FSL+CSII (n=149) users, with median follow-up duration of 1.4 (IQR 0.8–2.1) and 1.3 (IQR 0.7–1.8) years, respectively, were included. HbA1c with DIYAPS use changed by −10mmol/mol [0.9%] (p |
| Document Type: |
article in journal/newspaper |
| Language: |
English |
| Relation: |
https://nottingham-repository.worktribe.com/output/7223670; Diabetic Medicine; Volume 39; Issue 5 |
| DOI: |
10.1111/dme.14793 |
| Availability: |
https://doi.org/10.1111/dme.14793; https://nottingham-repository.worktribe.com/file/7223670/1/DIY%20FSL%20RV3%20V4%20Clean; https://nottingham-repository.worktribe.com/output/7223670 |
| Rights: |
openAccess |
| Accession Number: |
edsbas.80AA96C |
| Database: |
BASE |