| Title: |
Revisiting the association between vitamin D deficiency and active tuberculosis: A prospective case-control study in Taiwan |
| Authors: |
Meng-Shiuan Hsu; Tzu-Chien Chung; Ping-Huai Wang; Shih-Lung Cheng; Yen-Wen Wu; Jung-Cheng Hsu; Bing-Hsiean Tzeng; Heng-Hsu Lin; Chung-Ming Tu; Fang-Yeh Chu; Chi-Tai Fang |
| Source: |
Journal of Microbiology, Immunology and Infection, Vol 57, Iss 3, Pp 490-497 (2024) |
| Publisher Information: |
Elsevier |
| Publication Year: |
2024 |
| Collection: |
Directory of Open Access Journals: DOAJ Articles |
| Subject Terms: |
Tuberculosis; Vitamin D deficiency; Body mass index; Liver cirrhosis; Smoking; 25(OH)D; Microbiology; QR1-502 |
| Description: |
Background: To revisit the association between vitamin D deficiency (VDD, defined as serum 25(OH)D < 20 ng/ml) and incident active tuberculosis (TB), after two potentially underpowered randomized trials showed statistically non-significant 13%–22% decrease in TB incidence in vitamin D supplementation groups. Methods: We prospectively conducted an age/sex-matched case–control study that accounting for body-mass index (BMI), smoking, and other confounding factors to examine the association between VDD and active TB among non-HIV people in Taiwan (latitude 24°N), a high-income society which continues to have moderate TB burden. Results: We enrolled 62 people with incident active TB and 248 people in control group. The TB case patients had a significantly higher proportion of VDD compared to the control group (51.6% vs 29.8%, p = 0.001). The 25(OH)D level was also significantly lower in TB patients compared to control group (21.25 ± 8.93 ng/ml vs 24.45 ± 8.36 ng/ml, p = 0.008). In multivariable analysis, VDD (adjusted odds ratio [aOR]: 3.03, p = 0.002), lower BMI (aOR: 0.81, p < 0.001), liver cirrhosis (aOR: 8.99, p = 0.042), and smoking (aOR: 4.52, p = 0.001) were independent risk factors for incident active TB. Conclusions: VDD is an independent risk factor for incident active TB. Future randomized trials examining the effect of vitamin D supplementation on TB incidence should focus on people with a low BMI or other risk factors to maximize the statistical power. |
| Document Type: |
article in journal/newspaper |
| Language: |
English |
| Relation: |
http://www.sciencedirect.com/science/article/pii/S1684118224000689; https://doaj.org/toc/1684-1182; https://doaj.org/article/05567e1484a54ff19767c4078bfe5481 |
| DOI: |
10.1016/j.jmii.2024.03.005 |
| Availability: |
https://doi.org/10.1016/j.jmii.2024.03.005; https://doaj.org/article/05567e1484a54ff19767c4078bfe5481 |
| Accession Number: |
edsbas.8100222E |
| Database: |
BASE |