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Deep sequencing of the MHC region in the Chinese population contributes to studies of complex disease

Title:	Deep sequencing of the MHC region in the Chinese population contributes to studies of complex disease
Authors:	Zhou, Fusheng; Cao, Hongzhi; Zuo, Xianbo; Zhang, Tao; Zhang, Xiaoguang; Liu, Xiaomin; Xu, Ricong; Chen, Gang; Zhang, Yuanwei; Zheng, Xiaodong; Jin, Xin; Gao, Jinping; Mei, Junpu; Sheng, Yujun; Li, Qibin; Liang, Bo; Shen, Juan; Shen, Changbing; Jiang, Hui; Zhu, Caihong; Fan, Xing; Xu, Fengping; Yue, Min; Yin, Xianyong; Ye, Chen; Zhang, Cuicui; Liu, Xiao; Yu, Liang; Wu, Jinghua; Chen, Mengyun; Zhuang, Xuehan; Tang, Lili; Shao, Haojing; Wu, Longmao; Li, Jian; Xu, Yu; Zhang, Yijie; Zhao, Suli; Wang, Yu; Li, Ge; Xu, Hanshi; Zeng, Lei; Wang, Jianan; Bai
Contributors:	Sun, LD; Zhang, XJ (reprint author), Anhui Med Univ, Minist Educ, Hosp 1, Dept Dermatol, Hefei, Peoples R China.; Zhang, XJ (reprint author), Anhui Med Univ, Minist Educ, Key Lab Dermatol, Hefei, Peoples R China.; Hammarstrom, L; Wang, J (reprint author), BGI Shenzhen, Shenzhen, Peoples R China.; Wang, J (reprint author), iCarbonX, Shenzhen, Peoples R China.; Wang, J (reprint author), Univ Copenhagen, Dept Biol, Copenhagen, Denmark.; Zhang, XJ (reprint author), China Japan Friendship Hosp, Dept Der; Anhui Med Univ, Minist Educ, Hosp 1, Dept Dermatol, Hefei, Peoples R China.; Anhui Med Univ, Minist Educ, Key Lab Dermatol, Hefei, Peoples R China.; BGI Shenzhen, Shenzhen, Peoples R China.; iCarbonX, Shenzhen, Peoples R China.; Univ Copenhagen, Dept Biol, Copenhagen, Denmark.; Sun Yat Sen Univ, Affiliated Hosp 1, Dept Nephrol, Minist Hlth,Key Lab Nephrol, Guangzhou 510275, Guangdong, Peoples R China.; Southeast Univ, Sch Biol Sci & Med Engn, Nanjing, Jiangsu, Peoples R China.; China Japan Friendship Hosp, Dept Dermatol, Beijing, Peoples R China.; Anhui Med Univ, Hosp 2, Dept Dermatol, Hefei, Peoples R China.; Cent S Univ, Xiangya Hosp, Dept Dermatol, Changsha, Hunan, Peoples R China.; China Med Univ, Hosp 1, Dept Dermatol, Shenyang 110001, Peoples R China.; Shandong Acad Med Sci, Shandong Prov Inst Dermatol & Venereol, Jinan, Peoples R China.; Fudan Univ, Huashan Hosp, Dept Dermatol, Shanghai 200433, Peoples R China.; Fudan Univ, Collaborat Innovat Ctr Complex & Severe Skin Dis, Shanghai 200433, Peoples R China.; Zhejiang Univ, Sch Med, Affiliated Hosp 2, Dept Dermatol, Hangzhou 310003, Zhejiang, Peoples R China.; Shandong Jiaotong Univ, Sch Med, Ruijin Hosp, Dept Dermatol, Shanghai, Peoples R China.; Peking Univ, Peoples Hosp, Dept Dermatol, Beijing 100871, Peoples R China.; Univ Queensland, Inst Mol Biosci, Brisbane, Qld, Australia.; James D Watson Inst Genome Sci, Hangzhou, Zhejiang, Peoples R China.; Karolinska Univ Hosp Huddinge, Karolinska Inst, Dept Lab Med, Stockholm, Sweden.; King Abdulaziz Univ, Princess Al Jawhara Albrahim Ctr Excellence Res H, Jeddah 21413, Saudi Arabia.; Macau Univ Sci & Technol, Macau Inst Appl Res Med & Hlth, Taipa, Macau, Peoples R China.; Univ Hong Kong, Dept Med, Hong Kong, Hong Kong, Peoples R China.; Univ Hong Kong, State Key Lab Pharmaceut Biotechnol, Hong Kong, Hong Kong, Peoples R China.; Zhang, XJ (reprint author), China Japan Friendship Hosp, Dept Dermatol, Beijing, Peoples R China.; Zhang, XJ (reprint author), Anhui Med Univ, Hosp 2, Dept Dermatol, Hefei, Peoples R China.; Zhang, XJ (reprint author), Fudan Univ, Huashan Hosp, Dept Dermatol, Shanghai 200433, Peoples R China.; Zhang, XJ (reprint author), Fudan Univ, Collaborat Innovat Ctr Complex & Severe Skin Dis, Shanghai 200433, Peoples R China.; Hammarstrom, L (reprint author), Karolinska Univ Hosp Huddinge, Karolinska Inst, Dept Lab Med, Stockholm, Sweden.; Wang, J (reprint author), King Abdulaziz Univ, Princess Al Jawhara Albrahim Ctr Excellence Res H, Jeddah 21413, Saudi Arabia.; Wang, J (reprint author), Macau Univ Sci & Technol, Macau Inst Appl Res Med & Hlth, Taipa, Macau, Peoples R China.; Wang, J (reprint author), Univ Hong Kong, Dept Med, Hong Kong, Hong Kong, Peoples R China.; Wang, J (reprint author), Univ Hong Kong, State Key Lab Pharmaceut Biotechnol, Hong Kong, Hong Kong, Peoples R China.
Source:	PubMed ; SCI
Publisher Information:	NATURE GENETICS
Publication Year:	2016
Collection:	Peking University Institutional Repository (PKU IR) / 北京大学机构知识库
Subject Terms:	GENOME-WIDE ASSOCIATION; MAJOR HISTOCOMPATIBILITY COMPLEX; HIGH-RESOLUTION HLA; HAN CHINESE; RHEUMATOID-ARTHRITIS; RISK LOCI; VARIANTS; SUSCEPTIBILITY; PSORIASIS; MAP
Description:	The human major histocompatibility complex (MHC) region has been shown to be associated with numerous diseases. However, it remains a challenge to pinpoint the causal variants for these associations because of the extreme complexity of the region. We thus sequenced the entire 5-Mb MHC region in 20,635 individuals of Han Chinese ancestry (10,689 controls and 9,946 patients with psoriasis) and constructed a Han-MHC database that includes both variants and HLA gene typing results of high accuracy. We further identified multiple independent new susceptibility loci in HLA-C, HLA-B, HLA-DPB1 and BTNL2 and an intergenic variant, rs118179173, associated with psoriasis and confirmed the well-established risk allele HLA-C*06:02. We anticipate that our Han-MHC reference panel built by deep sequencing of a large number of samples will serve as a useful tool for investigating the role of the MHC region in a variety of diseases and thus advance understanding of the pathogenesis of these disorders. ; National Natural Science Foundation of China [81130031, 81573035, 81273301, 81271747, 81370044, 8157120504, 81502713]; National Science Fund for Excellent Young Scholars [81222022]; Top-Notch Young Talents Program of China; Pre-National Basic Research Program of China [2012CB722404]; Natural Science Foundation of Anhui Province [1508085JGD05]; Program of Outstanding Talents of Anhui Medical University; Shenzhen municipal government of China [CXZZ20140904154910774] ; SCI(E) ; PubMed ; ARTICLE ; lennart.hammarstrom@ki.se; ahmusld@163.com; wangj@genomics.cn; ayzxj@vip.sina.com ; 7 ; 740-+ ; 48
Document Type:	journal/newspaper
Language:	English
Relation:	1389469; http://hdl.handle.net/20.500.11897/433628; WOS:000378840100011
DOI:	10.1038/ng.3576
Availability:	https://hdl.handle.net/20.500.11897/433628; https://doi.org/10.1038/ng.3576
Accession Number:	edsbas.810403D7
Database:	BASE