| Title: |
African origin of the malaria parasite Plasmodium vivax |
| Authors: |
Liu, W.; Li, Y.; Shaw, Ks; Learn, Gh; Plenderleith, Lj; Malenke, Ja; Sundararaman, Sa; Ramirez, Ma; Crystal, Pa; Smith, Ag; Bibollet-Ruche, F; Ayouba, A.; Locatelli, Sabrina; Esteban, A; Mouacha, F; Guichet, E; Butel, C; Ahuka- Mundeke, S; Inogwabini, Bi; Ndjango, Jn; Speede, S; Sanz, Cm; Morgan, Db; Gonder, Mk; Kranzusch, Pj; Walsh, Pd; Georgiev, Av; Muller, Mn; Piel, Ak; Stewart, Fa; Wilson, Ml; Pusey, Ae; Cui, L; Wang, Z., G.; Färnert, A; Sutherland, Cj; Nolder, D; Hart, Ja; Hart, Tb; Bertolani, P; Agillis, A; Lebreton, M; Tafon, B; Kiyang, J; Djoko, Cf; Schneider, Bs; Wolfe, Nd; Mpoudi-Ngole, E; Delaporte, E.; Carter, R.; Culleton, Rl; Shaw, Gm; Rayner, Jc; Peeters, M; Hahn, Bh; Sharp, Pm |
| Contributors: |
Hospital of the University of Pennsylvania (HUP); Perelman School of Medicine; University of Pennsylvania Philadelphia -University of Pennsylvania Philadelphia; Recherches Translationnelles sur le VIH et les maladies infectieuses endémiques et émergentes (TransVIHMI); Université Montpellier 1 (UM1)-Institut de Recherche pour le Développement (IRD)-Université de Yaoundé I (UY1)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Cheikh Anta Diop de Dakar Sénégal (UCAD); Drexel University; Chinese Academy of Sciences Beijing (CAS); University College London UCL (UCL); The University of Edinburgh; This work was supported by grants from the National Institutes of Health (R01 AI091595, R37 AI050529, R01 AI58715, T32 AI007532, P30 AI045008), the Agence Nationale de Recherche sur le Sida (ANRS 12125/ 12182/12255), the Agence Nationale de Recherche (Programme Blanc, Sciences de la Vie, de la Sante ́ et des Ecosyste ́mes and ANR 11 BSV3 021 01, Projet PRIMAL), Harvard University, the Arthur L. Greene Fund, the Jane Goodall Institute, the Wellcome Trust (098051), the Leakey Foundation, Google.org and the Skoll Foundation. This study was also made possible by the generous support of the American people through the United States Agency for International Development (USAID) Emerging Pandemic Threats PREDICT. |
| Source: |
ISSN: 2041-1723. |
| Publisher Information: |
CCSD; Nature Publishing Group |
| Publication Year: |
2014 |
| Collection: |
Université de Montpellier: HAL |
| Subject Terms: |
[SDV.MP.PAR]Life Sciences [q-bio]/Microbiology and Parasitology/Parasitology; [SDV.BBM]Life Sciences [q-bio]/Biochemistry; Molecular Biology; [SDV.BID.EVO]Life Sciences [q-bio]/Biodiversity/Populations and Evolution [q-bio.PE] |
| Description: |
International audience ; Plasmodium vivax is the leading cause of human malaria in Asia and Latin America but is absent from most of central Africa due to the near fixation of a mutation that inhibits the expression of its receptor, the Duffy antigen, on human erythrocytes. The emergence of this protective allele is not understood because P. vivax is believed to have originated in Asia. Here we show, using a noninvasive approach, that wild chimpanzees and gorillas throughout central Africa are endemically infected with parasites that are closely related to human P. vivax. Sequence analyses reveal that ape parasites lack host specificity and are much more diverse than human parasites, which form a monophyletic lineage within the ape parasite radiation. These findings indicate that human P. vivax is of African origin and likely selected for the Duffy-negative mutation. All extant human P. vivax parasites are derived from a single ancestor that escaped out of Africa. |
| Document Type: |
article in journal/newspaper |
| Language: |
English |
| Relation: |
IRD: fdi:010075336 |
| DOI: |
10.1038/ncomms4346 |
| Availability: |
https://hal.science/hal-03058276; https://hal.science/hal-03058276v1/document; https://hal.science/hal-03058276v1/file/Liu%20et%20al_Ncomms%202014.pdf; https://doi.org/10.1038/ncomms4346 |
| Rights: |
https://about.hal.science/hal-authorisation-v1/ ; info:eu-repo/semantics/OpenAccess |
| Accession Number: |
edsbas.8156DAD3 |
| Database: |
BASE |