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COVID-19 Host Genetics Initiative. A first update on mapping the human genetic architecture of COVID-19

Title:	COVID-19 Host Genetics Initiative. A first update on mapping the human genetic architecture of COVID-19
Authors:	Gita A Pathak; Renato Polimanti; Juha Karjalainen; Mark Daly; Andrea Ganna; Mark J Daly; Christine Stevens; Masahiro Kanai; Rachel G Liao; Amy Trankiem; Mary K Balaconis; Huy Nguyen; Matthew Solomonson; Kumar Veerapen; Samuli Ripatti; Lindo Nkambul; Sam Bryant; Vijay G Sankaran; Benjamin M Neale; Konrad J Karczewski; Alicia R Martin; Elizabeth G Atkinson; Kristin Tsuo; Nikolas Baya; Patrick Turley; Rahul Gupta; Raymond K Walters; Duncan S Palmer; Gopal Sarma; Nathan Cheng; Wenhan Lu; Claire Churchhouse; Jacqueline Goldstein; Daniel King; Wei Zhou; Cotton Seed; Hilary Finucane; F Kyle Satterstrom; Shea J Andrews; Laura G Sloofman; Stuart C Sealfon; Clive Hoggart; Slayton J Underwood; Mattia Cordioli; Matti Pirinen; Kati Donner; Katja Kivinen; Aarno Palotie; Mari Kaunisto; Nadia Harerimana; Karolina Chwialkowska; Brooke Wolford; Genevieve Roberts; Danny Park; Catherine A Ball; Marie Coignet; Shannon McCurdy; Spencer Knight; Raghavendran Partha; Brooke Rhead; Miao Zhang; Nathan Berkowitz; Michael Gaddis; Keith Noto; Luong Ruiz; Milos Pavlovic; Eurie L Hong; Kristin Rand; Ahna Girshick; Harendra Guturu; Asher Haug Baltzell; Mari EK Niemi; Sara Pigazzini; Souad Rahmouni; Michel Georges; Yasmine Belhaj; Julien Guntz; Sabine Claassen; Yves Beguin; Stephanie Gofflot; Lindokuhle Nkambule; Lindokuhle Nkambul; Caroline Cusick; Michel Moutschen; Benoit Misset; Gilles Darcis; Julien Guiot; Samira Azarzar; Olivier Malaise; Pascale Huynen; Christelle Meuris; Marie Thys; Jessica Jacques; Philippe Leonard; Frederic Frippiat; Jean-Baptiste Giot; Anne-Sophie Sauvage; Christian Von Frenckell; Bernard Lambermont; Tomoko Nakanishi; David R Morrison; J Brent Richards; Guillaume Butler-Laporte; Vincenzo Forgetta; Biswarup Ghosh; Laetitia Laurent; Danielle Henry; Tala Abdullah; Olumide Adeleye; Noor Mamlouk; Nofar Kimchi; Zaman Afrasiabi; Nardin Rezk; Branka Vulesevic; Meriem Bouab; Charlotte Guzman; Louis Petitjean; Chris Tselios; Xiaoqing Xue; Jonathan Afilalo; Darin Adra; Vincent Mooser; Rui Li; Alexandre Belisle; Pierre Lepage; Jiannis Ragoussis; Daniel Auld; G Mark Lathrop; Marc Afilalo; Maureen Oliveira; Bluma Brenner; Nathalie Brassard; Madeleine Durand; Michael Chasse; Daniel E Kaufmann; Erwin Schurr; Caroline Hayward; Anne Richmond; J Kenneth Baillie; Joseph T Glessner; Hakon Hakonarson; Xiao Chang; Douglas M Shaw; Jennifer Below; Hannah Polikowski; Petty E Lauren; Hung-Hsin Chen; Wanying Zhu; Lea Davis; V Eric Kerchberger; Archie Campbell; David J Porteous; Chloe Fawns-Ritchie; Marcela Morris; Joseph B McCormick; Kari North; Joseph R Glessner; Christopher R Gignoux; Stephen J Wicks; Kristy Crooks; Kathleen C Barnes; Michelle Daya; Jonathan Shortt; Nicholas Rafaels; Sameer Chavan; Paul RHJ Timmers; James F Wilson; Albert Tenesa; Shona M Kerr; Kenton D'Mellow; Doaa Shahin; Yasser M El-Sherbiny; Jehan J El-Jawhari; Kathrin Aprile von Hohenstaufen; Ali Sobh; Madonna M Eltoukhy; Attia AS Mohamed; Tamer A Elhadidy; Mohamed S Abd Elghafar; Marwa H Elnagdy; Amr Samir; Mohamed AF Hegazy; Mahmoud Abdel-Aziz; Walid T Khafaga; Walaa M El-Lawaty; Mohamed S Torky; Hanteera S Moahmed; Mohamed R El-shanshory; Amr M Yassen; Kamal Okasha; Mohammed A Eid; Carolina Medina-Gomez; Andre G Uitterlinden; M Arfan Ikram; Reedik Magi; Lili Milani; Andres Metspalu; Triin Laisk; Kristi Lall; Maarja Lepamets; Tonu Esko; Ene Reimann; Helene Alavere; Kristjan Metsalu; Mairo Puusepp; Paul Naaber; Edward Laane; Jaana Pesukova; Part Peterson; Kai Kisand; Jekaterina Tabri; Raili Allos; Kati Hensen; Joel Starkopf; Inge Ringmets; Anu Tamm; Anne Kallaste; Chiara Batini; Martin D Tobin; Laura D Venn; Paul H Lee; Nick Shrine; Alexander T Williams; Anna L Guyatt; Catherine John; Richard J Packer; Altaf Ali; Xueyang Wang; Louise Wain; Catherine E Bee; Emma L Adams; Robert C Free; Edward J Hollox; Sanni Ruotsalainen; Kati Kristiansson; Sami Koskelainen; Markus Perola; Carlo Rivolta; Mathieu Quinodoz; Dhryata Kamdar; Pierre-Yves Bochud; Noemie Boillat; Stephanie Bibert; Semira Gonseth Nussle; Werner Albrich; Noemie Suh; Dionysios Neofytos; Veronique Erard; Cathy Voide; R Friolet; P Vollenweider; JL Pagani; M Oddo; F Meyer zu Bentrup; A Conen; O Clerc; O Marchetti; A Guillet; C Guyat-Jacques; S Foucras; M Rime; J Chassot; M Jaquet; R Merlet Viollet; Y Lannepoudenx; L Portopena; PY Bochud; F Desgranges; P Filippidis; B Guery; D Haefliger; EE Kampouri; O Manuel; A Munting; M Papadimitriou-Olivgeris; J Regina; L Rochat-Stettler; V Suttels; E Tadini; J Tschopp; M Van Singer; B Viala; N Boillat-Blanco; T Brahier; O Hugli; JY Meuwly; O Pantet; S Gonseth Nussle; M Bochud; V D'Acremont; S Estoppey Younes; WC Albrich; N Suh; A Cerny; L O'Mahony; C von Mering; M Frischknecht; G-R Kleger; M Filipovic; CR Kahlert; H Wozniak; T Rochat Negro; J Pugin; K Bouras; C Knapp; T Egger; A Perret; P Montillier; C di Bartolomeo; B Barda; Rafael de Cid; Anna Carreras; Ivan Galvan-Femenia; Natalia Blay; Xavier Farre; Lauro Sumoy; Beatriz Cortes; Victor Moreno; Manolis Kogevinas; Judith Garcia-Aymerich; Gemma Castano-Vinyals; Carlota Dobano; Josep Maria Mercader; Josep Mercader; Marta Guindo-Martinez; David Torrents; Marco Gori; Nicola Picchiotti; Marco Tanfoni; Alessandra Renieri; Francesca Mari; Chiara Fallerini; Sergio Daga; Margherita Baldassarri; Francesca Fava; Elisa Frullanti; Floriana Valentino; Gabriella Doddato; Annarita Giliberti; Mirella Bruttini; Susanna Croci; Ilaria Meloni; Giada Beligni; Laura Di Sarno; Maria Palmieri; Miriam Lucia Carriero; Diana Alaverdian; Rossella Tita; Sara Amitrano; Maria Antonietta Mencarelli; Caterina Lo Rizzo; Anna Maria Pinto; Francesca Montagnani; Mario Tumbarello; Simone Furini; Elisa Benetti; Kristina Zguro; Katia Capitani; Francesco Bianchi; Mirjam Lista; Mario Umberto Mondelli; Raffaele Bruno; Francesco Castelli; Eugenia Quiros-Roldan; Melania Degli Antoni; Massimo Vaghi; Stefano Rusconi; Agostino Riva; Matteo Siano; Arianna Gabrieli; Massimiliano Fabbiani; Barbara Rossetti; Ilaria Rancan; Elena Bargagli; Laura Bergantini; Miriana D'Alessandro; Paolo Cameli; David Bennett; Federico Franchi; Federico Anedda; Simona Marcantonio; Sabino Scolletta; Maria Antonietta Mazzei; Susanna Guerrini; Luca Cantarini; Edoardo Conticini; Bruno Frediani; Danilo Tacconi; Chiara Spertilli; Marco Feri; Alice Donati; Raffaele Scala; Luca Guidelli; Genni Spargi; Marta Corridi; Cesira Nencioni; Leonardo Croci; Maria Bandini; Paolo Piacentini; Elena Desanctis; Silvia Cappelli; Gian Piero Caldarelli; Anna Canaccini; Agnese Verzuri; Valentina Anemoli; Agostino Ognibene; Alessandro Pancrazzi; Maria Lorubbio; Antonella D'Arminio Monforte; Federica Gaia Miraglia; Massimo Girardis; Stefano Busani; Sophie Venturelli; Andrea Antinori; Arianna Emiliozzi; Alessandra Vergori; Daniela Francisci; Elisabetta Schiaroli; Andrea Tommasi; Francesco Paciosi; Pier Giorgio Scotton; Francesca Andretta; Sandro Panese; Renzo Scaggiante; Francesca Gatti; Matteo Della Monica; Carmelo Piscopo; Mario Capasso; Roberta Russo; Immacolata Andolfo; Achille Iolascon; Giuseppe Merla; Giuseppe Fiorentino; Marco Castori; Massimo Carella; Filippo Aucella; Antonio Di Biagio; Matteo Bassetti; Luca Masucci; Maurizio Sanguinetti; Alessandra Guarnaccia; Serafina Valente; Oreste De Vivo; Marco Mandala; Alessia Giorli; Lorenzo Salerni; Patrizia Zucchi; Pierpaolo Parravicini; Ferdinando Giannattasio; Tullio Trotta; Gabriella Coiro; Domenico A Coviello; Cristina Mussini; Luisa Tavecchia; Mary Ann Belli; Sandro Mancarella; Lia Crotti; Gianfranco Parati; Marco Rizzi; Franco Maggiolo; Diego Ripamonti; Maria Teresa La Rovere; Simona Sarzi-Braga; Maurizio Bussotti; Sabrina Ravaglia; Rosangela Artuso; Elena Andreucci; Antonio Perrella; Davide Romani; Paola Bergomi; Emanuele Catena; Riccardo Colombo; Antonella Vincenti; Claudio Ferri; Davide Grassi; Gloria Pessina; Monica Poscente; Massimo Di Pietro; Ravaglia Sabrina; Sauro Luchi; Simona Dei; Maurizio Sanarico; Chiara Gabbi; Stefano Ceri; Pietro Pinoli; Francesco Raimondi; Filippo Biscarini; Alessandra Stella; Marco Vecchia; Stefania Mantovani; Serena Ludovisi; Isabella Zanella; Andrea Cossarizza; Saverio Giuseppe Parisi; Stefano Baratti; Gabriella Maria Squeo; Pamela Raggi; Carmen Marciano; Rita Perna; Elisabetta Menatti; Fabio Lena; Enrico Martinelli; Tiziana Bachetti; Claudia Suardi; Giordano Botta; Paolo Di Domenico; Chiara Barbieri; Giusy Tiseo; Marco Falcone; Donatella Acquilini; Francesco Vladimiro Segala; Paola Petrocelli; Silvia Baroni; David A van Heel; Karen A Hunt; David van Heel; Richard C Trembath; Qin Qin Huang; Hilary C Martin; Dan Mason; John Wright; Bhavi Trivedi; Sarah Finer; Shaheen Akhtar; Mohammad Anwar; Elena Arciero; Samina Ashraf; Gerome Breen; Raymond Chung; Charles J Curtis; Maharun Chowdhury; Grainne Colligan; Panos Deloukas; Ceri Durham; Chris Griffiths; Matt Hurles; Shapna Hussain; Kamrul Islam; Ahsan Khan; Amara Khan; Cath Lavery; Sang Hyuck Lee; Robin Lerner; Daniel MacArthur; Bev MacLaughlin; Hilary Martin; Shefa Miah; Bill Newman; Nishat Safa; Farah Tahmasebi; Christopher J Griffiths; Albert Smith; Andrew P Boughton; Kevin W Li; Jonathon LeFaive; Aubrey Annis; Sebastian Zollner; Jiongming Wang; Andrew Beck; Ahmadreza Niavarani; Bahareh Sharififard; Rasoul Aliannejad; Zeinab Naderpour; Ali Amirsavadkouhi; Hengameh Ansari Tadi; Afshar Etemadi Aleagha; Saeideh Ahmadi; Seyed Behrooz Mohseni Moghaddam; Alireza Adamsara; Morteza Saeedi; Hamed Abdollahi; Abdolmajid Hosseini; Pajaree Chariyavilaskul; Watsamon Jantarabenjakul; Opass Putchareon; Pattama Torvorapanit; Thanyawee Puthanakit; Nattiya Hirankarn; Pimpayao Sodsai; Monpat Chamnanphon; Thitima B Suttichet; Vorasuk Shotelersuk; Chureerat Phokaew; Wanna Chetruengchai; Monnat Pongpanich; Pintip Suchartlikitwong; Voraphoj Nilaratanakul; Ben M Brumpton; Kristian Hveem; Bjorn Olav Asvold; Cristen Willer; Tormod Rogne; Erik Solligard; Lude Franke; Annique Claringbould; Esteban Lopera; Robert Warmerdam; Irene van Blokland; Marike Boezen; Patrick Deelen; Judith M Vonk; Pauline Lanting; Anil PS Ori; Yen-Chen Anne Feng; Scott T Weiss; Elizabeth W Karlson; Ann E Woolley; Jordan W Smoller; Shawn N Murphy; James B Meigs; Robert C Green; Emma F Perez; Steven Ascolillo; Ryan C Thompson; Noam D Beckmann; Robert P Sebra; Kyle Gettler; Irene Salib; Marissa Zyndorf; Eric E Schadt; Brett L Collins; Tess Levy; Joseph D Buxbaum; Bari Britvan; Katherine Keller; Lara Tang; Michael Peruggia; Liam L Hiester; Kristi Niblo; Alexandra Aksentijevich; Alexander Labkowsky; Avromie Karp; Menachem Zlatopolsky; Daniel M Jordan; Kumardeep Chaudhary; Judy H Cho; Yuval Itan; Ron Do; Girish N Nadkarni; Michael Preuss; Ruth JF Loos; Gillian M Belbin; Noura S Abul-Husn; Eimear E Kenny; Sam Choi; Paul O'Reilly; Alexander W Charney; Laura M Huckins; Manuel AR Ferreira; Goncalo R Abecasis; Michael N Cantor; Jack A Kosmicki; Julie E Horowitz; Aris Baras; Ashish Yadav; Joseph B Leader; Matthew C Gass; Anne E Justice; Geetha Chittoor; Navya Shilpa Josyula; Dave J Carey; Tooraj Mirshahi; Jouke Jan Hottenga; Meike Bartels; Eco EJC de Geus; Michel MG Nivard; Anurag Verma; Marylyn D Ritchie; Daniel Rader; Shefali S Verma; Anastasia Lucas; Yuki Bradford; Binglan Li; Malak Abedalthagafi; Fawz Al Harthi; Ebtehal Alsolm; Leen Abu Safieh; Albandary M Alowayn; Fatimah Alqubaishi; Amal Al Mutairi; Hadeel AlBardis; Sara Alotaibi; Mohammad S Fawzy; Manal Alaamery; Salam Massadeh; Mansour Almutairi; Abdulraheem Alshareef; Bandar A Suliman; Mona Sawaji; Abdulaziz AlMalik; Saleh Alqahtani; Dona Baraka; Rana Hasanato; Serghei Mangul; Nora Aljawini; Nour Albesher; Sarah Alkwai; Moneera Alswailm; Iman Almohammed; Yaseen M Arabi; Ebrahim S Mahmoud; Amin K Khattab; Roaa T Halawani; Ziab Z Alahmadey; Jehad K Albakri; Walaa A Felemban; Laila Al-Awdah; Jahad Alghamdi; Deema AlZahrani; Nouf AlDhawi; Faisal Almalki; Maha Albeladi; Anoud Albader; Sameera AlJohani; Hani Al-Afghani; Eman Barhoush; Bader Alghamdi; Junghyun Jung; May Alrashed; Hugo Zeberg; Tomislav Maricic; Robert Frithiof; Michael Hultstrom; Miklos Lipcsey; Nicolas Tardif; Olav Rooyackers; Jonathan Grip; Oyvind Helgeland; Jennifer R Harris; Per Magnus; Yunsung Lee; Lill-Iren S Trogstad; Massimo Mangino; Tim D Spector; Duncan Emma; Loukas Moutsianas; Mark J Caulfield; Richard H Scott; Augusto Rendon; Athanasios Kousathanas; Dorota Pasko; Susan Walker; Alex Stuckey; Christopher A Odhams; Daniel Rhodes; Tom Fowler; Georgia Chan; Prabhu Arumugam; Daniel J Wilson; Sarah G Earle; Shang-Kuan Lin; Nicolas Arning; Jacob Armstrong; Justine K Rudkin; Chris CA Spencer; Nils Koelling; Derrick W Crook; David H Wyllie; Anne Marie O'Connell; Gavin Band; Shawneequa Callier; Nicole Soranzo; Jing Hua Zhao; John Danesh; Emanuele Di Angelantonio; Adam S Butterworth; Yan Sun; Jennifer E Huffman; Christopher J O'Donnell; Gina Peloso; Kelly Cho; J Michael Gaziano; Yuk-Lam Ho; Phil Tsao; James Priest; Sandra P Smieszek; Christos Polymeropoulos; Vasilios Polymeropoulos; Mihael H Polymeropoulos; Bartlomiej P Przychodzen; Israel Fernandez-Cadenas; Laia Llucia-Carol; Natalia Cullell; Elena Muino; Jara Carcel-Marquez; Anna M Planas; Jordi Perez-Tur; Marta L DeDiego; Lara Lloret Iglesias; Alex Soriano; Veronica Rico; Daiana Aguero; Josep L Bedini; Carlos Domingo; Veronica Robles; Francisco Lozano; Francisca Ruiz-Jaen; Leonardo Marquez; Juan Gomez; Eliecer Coto; Guillermo M Albaiceta; Marta Garcia-Clemente; David Dalmau; Maria J Arranz; Beatriz Dietl; Alex Serra-Llovich; Pere Soler; Roger Colobran; Andrea Martin-Nalda; Alba Parra Martinez; David Bernardo; Aida Fiz-Lopez; Elisa Arribas; Paloma De La Cal-Sabater; Silvia Rojo; Tomas Segura; Esther Gonzalez-Villa; Gemma Serrano-Heras; Joan Marti-Fabregas; Elena Jimenez-Xarrie; Alicia de Felipe Mimbrera; Jaime Masjuan; Sebastian Garcia-Madrona; Anna Dominguez-Mayoral; Joan Montaner Villalonga; Paloma Menendez-Valladares; Daniel Chasman; Howard D Sesso; JoAnn E Manson; Julie E Buring; Paul M Ridker; Giulianini Franco; Sulggi Lee; Les Biesecker
Publication Year:	2022
Collection:	University of Leicester: Figshare
Subject Terms:	Science & Technology; Multidisciplinary Sciences; Science & Technology - Other Topics; MUC5B PROMOTER POLYMORPHISM
Description:	The COVID-19 pandemic continues to pose a major public health threat, especially in countries with low vaccination rates. To better understand the biological underpinnings of SARS-CoV-2 infection and COVID-19 severity, we formed the COVID-19 Host Genetics Initiative1. Here we present a genome-wide association study meta-analysis of up to 125,584 cases and over 2.5 million control individuals across 60 studies from 25 countries, adding 11 genome-wide significant loci compared with those previously identified2. Genes at new loci, including SFTPD, MUC5B and ACE2, reveal compelling insights regarding disease susceptibility and severity.
Document Type:	article in journal/newspaper
Language:	unknown
Relation:	2381/20769022.v1
Availability:	https://figshare.com/articles/journal_contribution/COVID-19_Host_Genetics_Initiative_A_first_update_on_mapping_the_human_genetic_architecture_of_COVID-19/20769022
Rights:	CC BY 4.0
Accession Number:	edsbas.8198CA4F
Database:	BASE