| Title: |
Adiposity assessed close to diagnosis and prostate cancer prognosis in the EPIC study |
| Authors: |
Cariolou, Margarita; Christakoudi, Sofia; Gunter, Marc J.; Key, Tim; Pérez Cornago, Aurora; Travis, Ruth; Zamora-Ros, Raul; Petersen, Kristina Elin T.; Tjønneland, Anne; Weiderpass, Elisabete; Kaaks, Rudolf; Seibold, Petra; Inan Eroglu, Elif; Schulze, Matthias B.; Masala, Giovanna; Agnoli, Claudia; Tumino, Rosario; Di Girolamo, Chiara; Aizpurua, Amaia; Rodriguez Barranco, Miguel; Santiuste, Carmen; Guevara, Marcela; Aune, Dagfinn; Chan, Doris S. M.; Muller, David C.; Tsilidis, Konstantinos K. |
| Source: |
Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL)) |
| Publisher Information: |
Oxford University Press (OUP) |
| Publication Year: |
2024 |
| Collection: |
Dipòsit Digital de la Universitat de Barcelona |
| Subject Terms: |
Càncer de pròstata; Obesitat; Pronòstic mèdic; Prostate cancer; Obesity; Prognosis |
| Description: |
Background Adiposity has been characterized as a modifiable risk factor for prostate cancer. Its association with outcomes after prostate cancer diagnosis, however, must be better understood, and more evidence is needed to facilitate the development of lifestyle guidance for patients with prostate cancer.Methods We investigated the associations between adiposity indices close to prostate cancer diagnosis (up to 2 years before or up to 5 years after diagnosis) and mortality in 1968 men of the European Prospective Investigation into Cancer and Nutrition cohort. Men were followed up for a median of 9.5 years. Cox proportional hazards models were adjusted for age and year of diagnosis, disease stage and grade, and smoking history and stratified by country.Results Each 5-unit increment in prediagnosis or postdiagnosis body mass index combined was associated with a 30% higher rate of all-cause mortality and a 49% higher rate of prostate cancer-specific mortality. Similarly, each 5-unit increment in prediagnosis body mass index was associated with a 35% higher rate of all-cause mortality and a 51% higher rate of prostate cancer-specific mortality. The associations were less strong for postdiagnosis body mass index, with a lower number of men in analyses. Less clear positive associations were shown for waist circumference, hip circumference, and waist to hip ratio, but data were limited.Conclusions Elevated levels of adiposity close to prostate cancer diagnosis could lead to higher risk of mortality; therefore, men are encouraged to maintain a healthy weight. Additional research is needed to confirm whether excessive adiposity after prostate cancer diagnosis could worsen prognosis. |
| Document Type: |
article in journal/newspaper |
| File Description: |
12 p.; application/pdf |
| Language: |
English |
| Relation: |
Reproducció del document publicat a: https://doi.org/10.1093/jncics/pkae070; JNCI Cancer Spectrum, 2024, vol. 8, num. 5; https://doi.org/10.1093/jncics/pkae070; https://hdl.handle.net/2445/216511 |
| Availability: |
https://hdl.handle.net/2445/216511 |
| Rights: |
cc-by (c) Cariolou, Margarita et al., 2024 ; http://creativecommons.org/licenses/by/3.0/es/ ; info:eu-repo/semantics/openAccess |
| Accession Number: |
edsbas.81B1339 |
| Database: |
BASE |