| Title: |
Evaluation for the withdrawal syndrome from gamma-hydroxybutyric acid (GHB), gamma-butyrolactone (GBL), and 1,4-butanediol (1,4-BD) in different rat lines. |
| Authors: |
Quang LS; Colombo G; Lobina C; Maccioni P; Gessa GL; Maher TJ; Carai MA; ORRU', ALESSANDRO |
| Contributors: |
Quang, L; Colombo, G; Lobina, C; Maccioni, P; Orru', Alessandro; Gessa, Gl; Maher, Tj; Carai, Ma |
| Publication Year: |
2006 |
| Collection: |
Università degli Studi di Cagliari: UNICA IRIS |
| Description: |
A severe and life-threatening gamma-hydroxybutyric acid (GHB) withdrawal syndrome, clinically similar to the alcohol withdrawal syndrome, is increasingly being reported in GHB addicts. We investigated for the occurrence of withdrawal in Wistar and Sprague-Dawley rats, and in the selectively bred lines of GHB-sensitive (GHB-S) and Sardinian alcohol-preferring (sP) rats, following chronic administration of GHB, gamma-butyrolactone (GBL), and/or 1,4-butanediol (1,4-BD). Using validated rodent alcohol withdrawal scoring scales, little to no spontaneous or pharmacologically precipitated withdrawal effects were observed in Wistar, Sprague-Dawley, or GHB-S rats. Conversely, sP rats displayed both spontaneous and precipitated audiogenic seizures following abrupt cessation of chronic GHB or 1,4-BD administration and following pharmacological challenge with the GABA(B) receptor-selective antagonist, SCH 50911, respectively. |
| Document Type: |
article in journal/newspaper |
| Language: |
English |
| Relation: |
volume:1074; firstpage:545; lastpage:558; numberofpages:14; journal:ANNALS OF THE NEW YORK ACADEMY OF SCIENCES; https://hdl.handle.net/11584/86031 |
| Availability: |
https://hdl.handle.net/11584/86031 |
| Accession Number: |
edsbas.81D334EA |
| Database: |
BASE |