A vaccine antigen central in influenza A(H5) virus antigenic space confers subtype-wide immunity
| Title: | A vaccine antigen central in influenza A(H5) virus antigenic space confers subtype-wide immunity |
|---|---|
| Authors: | Kok, Adinda; Wilks, Samuel H; Tureli, Sina; James, Sarah L; Bestebroer, Theo M; Burke, David F; Funk, Mathis; van der Vliet, Stefan; Spronken, Monique I; Rijnink, Willemijn F; Pattinson, David; de Meulder, Dennis; Rosu, Miruna E; Lexmond, Pascal; van den Brand, Judith M A; Herfst, Sander; Smith, Derek J; Fouchier, Ron A M; Richard, Mathilde |
| Source: | Kok, A, Wilks, S H, Tureli, S, James, S L, Bestebroer, T M, Burke, D F, Funk, M, van der Vliet, S, Spronken, M I, Rijnink, W F, Pattinson, D, de Meulder, D, Rosu, M E, Lexmond, P, van den Brand, J M A, Herfst, S, Smith, D J, Fouchier, R A M & Richard, M 2024, 'A vaccine antigen central in influenza A(H5) virus antigenic space confers subtype-wide immunity', bioRxiv : the preprint server for biology. https://doi.org/10.1101/2024.08.06.606696 |
| Publication Year: | 2024 |
| Subject Terms: | /dk/atira/pure/sustainabledevelopmentgoals/good_health_and_well_being; name=SDG 3 - Good Health and Well-being |
| Description: | Highly pathogenic avian influenza A(H5) viruses globally impact wild and domestic birds, and mammals, including humans, underscoring their pandemic potential. The antigenic evolution of the A(H5) hemagglutinin (HA) poses challenges for pandemic preparedness and vaccine design. Here, the global antigenic evolution of the A(H5) HA was captured in a high-resolution antigenic map. The map was used to engineer immunogenic and antigenically central vaccine HA antigens, eliciting antibody responses that broadly cover the A(H5) antigenic space. In ferrets, a central antigen protected as well as homologous vaccines against heterologous infection with two antigenically distinct viruses. This work showcases the rational design of subtype-wide influenza A(H5) pre-pandemic vaccines and demonstrates the value of antigenic maps for the evaluation of vaccine-induced immune responses through antibody profiles. |
| Document Type: | article in journal/newspaper |
| File Description: | application/pdf |
| Language: | English |
| ISSN: | 2692-8205 |
| Relation: | info:eu-repo/semantics/altIdentifier/pmid/39553979; info:eu-repo/semantics/altIdentifier/pissn/2692-8205; info:eu-repo/semantics/altIdentifier/eissn/2692-8205 |
| DOI: | 10.1101/2024.08.06.606696 |
| Availability: | https://pure.eur.nl/en/publications/e465b37a-7717-44b8-8baa-4f9730c13aab; https://doi.org/10.1101/2024.08.06.606696; https://pure.eur.nl/ws/files/186590347/A_vaccine_antigen_central_in_influenza_A_H5_virus_antigenic_space_confers_subtype-wide_immunity.pdf |
| Rights: | info:eu-repo/semantics/openAccess ; http://creativecommons.org/licenses/by/4.0/ |
| Accession Number: | edsbas.821D1C1D |
| Database: | BASE |