| Title: |
The trend of VEGF-A and PlGF in pregnant patients: a perspective case-control study on 214 women. |
| Authors: |
Patrelli TS; BASSO, DANIELA; Capobianco G; Bartolucci C; Modena AB; Rondinelli M; GIZZO, SALVATORE; PLEBANI, MARIO; NARDELLI, GIOVANNI BATTISTA |
| Contributors: |
Patrelli, T; Gizzo, Salvatore; Plebani, Mario; Basso, Daniela; Capobianco, G; Bartolucci, C; Modena, Ab; Rondinelli, M; Nardelli, GIOVANNI BATTISTA |
| Publisher Information: |
I R O G CANADA, INC |
| Publication Year: |
2012 |
| Collection: |
Padua Research Archive (IRIS - Università degli Studi di Padova) |
| Subject Terms: |
Abortion; Ectopic pregnancy; IUGR; PLGF; Preeclampsia; Pregnancy; Preterm delivery; Twin pregnancie; VEGF |
| Description: |
Objective: The aim of this study was to measure plasmatic concentrations of vascular endothelial growth factor-A (VEGF-A) and placental growth factor (PIGF) in pregnant women, and to evaluate their relationship with age, hormonal status, gestational age, and different diseases of pregnancy. Methods: We selected a control group of 163 patients (96 fertile and 67 in menopause) and a group of 214 pregnant patients during the whole gestational period. VEGF-A and PIGF were assayed by ELISA and EIA methods, respectively. Statistical analysis was performed using the Mann-Whitney test. Results: The control group showed mean VEGF-A and PIGF values of 89.87 pg/ml and 10.22 pg/ml, respectively; PIGF showed the highest values in menopausal patients. The group of pregnant patients showed VEGF-A values of 27.05 pg/ml and PIGF values of 231.36 pg/ml respectively, with lower (for the VEGF-A) and higher (for the PIGF) statistical significance. These values were not influenced by biological age, but were related to gestational age: VEGF-A showed a decrease and PIGF an increase particularly after the 20 th gestational week. PIGF showed a statistically significant decrease compared to physiological gestation in spontaneous and threatened abortions (p < 0.0001) and in ectopic pregnancies (p < 0.0001), an increase in ultrasound and CTG alterations (p < 0.05), and threatened premature delivery and uterine hypercontractility (p < 0.01); on the other hand VEGF-A showed a statistically significant increase in ectopic pregnancies (p < 0.05). Conclusions: VEGF-A and PIGF may play a diagnostic and prognostic role in pregnancy. Further studies are required to better understand the meaning of variability of their values. |
| Document Type: |
article in journal/newspaper |
| File Description: |
STAMPA |
| Language: |
English |
| Relation: |
info:eu-repo/semantics/altIdentifier/pmid/22675957; info:eu-repo/semantics/altIdentifier/wos/WOS:000301509900014; volume:39; issue:1; firstpage:57; lastpage:64; numberofpages:8; journal:CLINICAL AND EXPERIMENTAL OBSTETRICS & GYNECOLOGY; https://hdl.handle.net/11577/2516748 |
| Availability: |
https://hdl.handle.net/11577/2516748 |
| Accession Number: |
edsbas.825A0E67 |
| Database: |
BASE |