| Title: |
Anticoagulation Practice and Risk of Portal Vein Thrombosis Following Pancreaticoduodenectomy or Total Pancreatectomy with Venous Resection An International Multicentre Cohort Study |
| Authors: |
Labib, Peter L; McKay, Siobhan C; Perrodin, Stéphanie F; Bolm, Louisa; Mownah, Omar A; Bellotti, Ruben; McClements, Jane; Sultana, Asma; Skipworth, James Ra; Balakrishnan, Anita; Durán, Manuel; Moris, Dimitrios; Milburn, James A; Kurtoğlu, Gökalp K; Carino, Nicola De'Liguori; Domínguez-Rosado, Ismael; Pandanaboyana, Sanjay; Ghotbi, Jacob; Marchegiani, Giovanni; Athwal, Tejinderjit S; Stättner, Stefan; Karavias, Dimitrios D; Al-Sarireh, Bilal; Morris, Paul D; Connor, Saxon; Halimi, Asif; Leonhardt, Carl-Stephan; Hodgson, Russell; Samra, Jaswinder S; Mittal, Anubhav; Fisher, Oliver M; Lim, Christopher Sh; Banting, Simon W; Koea, Jonathan; Yoshino, Osamu; Silva, Michael A; Bhogal, Ricky H; Croagh, Daniel; Cavallucci, David J; Loveday, Benjamin Pt; Dunne, Declan Fj; Aroori, Somaiah; Davidson, Brian R; Roberts, Keith J; PVR audit collaborators |
| Source: |
Annals of Surgery (2025) (In press). |
| Publisher Information: |
Lippincott, Williams & Wilkins |
| Publication Year: |
2025 |
| Collection: |
University College London: UCL Discovery |
| Subject Terms: |
anticoagulants; pancreatectomy; pancreatic neoplasms; portal vein; survival; venous thrombosis |
| Description: |
OBJECTIVE: Assess anticoagulation practice and portal vein thrombosis (PVT) risk following pancreaticoduodenectomy (PD) or total pancreatectomy (TP) with venous resection (VR). BACKGROUND: Retrospective studies suggest an increased risk of PVT following PD/TP with VR. However, anticoagulation practice is variable and its efficacy at preventing PVT is unknown. METHODS: This multicentre cohort study (Europe, USA, Mexico, Turkey, Australia, New Zealand) included consecutive patients undergoing PD/TP with VR between 2018-2022. A 1:1 age and sex matched cohort undergoing PD/TP without VR was also collected to assess PVT risk without VR. RESULTS: Among 972 patients who underwent PD/TP with VR, 259 (26.6%) received inpatient therapeutic anticoagulation and 242 (25.0%) were discharged on therapeutic anticoagulation. Thirty-day, 90-day and one-year PVT risk following VR was 5.1%, 7.3%, and 11.6%, versus 1.0%, 1.3% and 2.6% in patients without VR (P |
| Document Type: |
article in journal/newspaper |
| Language: |
English |
| Relation: |
https://discovery.ucl.ac.uk/id/eprint/10214934/ |
| Availability: |
https://discovery.ucl.ac.uk/id/eprint/10214934/ |
| Accession Number: |
edsbas.82860412 |
| Database: |
BASE |