| Title: |
Higher maternal adiposity reduces offspring birthweight if associated with a metabolically favourable profile |
| Authors: |
Thompson, WD; Beaumont, RN; Kuang, A; Warrington, NM; Ji, Y; Tyrrell, J; Wood, AR; Scholtens, DM; Knight, BA; Evans, DM; Lowe, WL; Santorelli, G; Azad, R; Mason, D; Hattersley, AT; Frayling, TM; Yaghootkar, H; Borges, MC; Lawlor, DA; Freathy, RM |
| Publisher Information: |
Springer Nature |
| Publication Year: |
2021 |
| Collection: |
Brunel University London: Brunel University Research Archive (BURA) |
| Subject Terms: |
adiposity; ALSPAC; BiB; BMI; EFSOCH; glucose; HAPO; insulin; Mendelian randomisation; UKB |
| Description: |
Data availability: Our study uses two-sample MR. We used both published summary results (i.e. taking results from published research papers and websites) and individual participant cohort data: journal-published and website summary data were used for sample one of the two-sample MR (published GWAS of BMI and body fat percentage). The references to the published data sources are provided in the main paper. The data for the GWAS of BMI are available at https://portals.broadinstitute.org/collaboration/giant/index.php/GIANT_consortium_data_files. The data for the GWAS of body fat percentage are available at https://walker05.u.hpc.mssm.edu. We used individual participant data for the second MR sample and for undertaking sensitivity analyses from the UKB, ALSPAC, BiB, EFSOCH and HAPO cohorts. The data in UKB, ALSPAC and BiB are fully available, via managed systems, to any researchers. The managed system for both studies is a requirement of the study funders but access is not restricted on the basis of overlap with other applications to use the data or on the basis of peer review of the proposed science. Researchers have to pay for a dataset to be prepared for them. Full information on how to access UKB data can be found at www.ukbiobank.ac.uk/using-the-resource/. The ALSPAC data management plan (www.bristol.ac.uk/alspac/researchers/data-access/documents/alspac-data-management-plan.pdf) describes, in detail, the policy regarding data sharing, which is through a system of managed open access. The following steps highlight how to apply for access to the data included in this paper and all other ALSPAC data: (1) please read the ALSPAC access policy (PDF, 627 kB), which describes the process of accessing the data and samples in detail, and outlines the costs associated with doing so; (2) you may also find it useful to browse the fully searchable ALSPAC research proposals database, which lists all research projects that have been approved since April 2011; (3) please submit your research proposal for consideration by the ... |
| Document Type: |
article in journal/newspaper |
| File Description: |
2790 - 2802; Print-Electronic |
| Language: |
English |
| Relation: |
Diabetologia; https://bura.brunel.ac.uk/handle/2438/25393 |
| DOI: |
10.1007/s00125-021-05570-9 |
| Availability: |
https://bura.brunel.ac.uk/handle/2438/25393; https://doi.org/10.1007/s00125-021-05570-9 |
| Rights: |
Copyright © The Author(s) 2022. Rights and permissions: Open Access. This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit https://creativecommons.org/licenses/by/4.0/. ; https://creativecommons.org/licenses/by/4.0/ ; The Author(s) |
| Accession Number: |
edsbas.830EFB83 |
| Database: |
BASE |