| Title: |
Associations of circulating choline and its related metabolites with cardiometabolic biomarkers: an international pooled analysis |
| Authors: |
Pan XF; Yang JJ; Shu XO; Moore SC; Palmer ND; Guasch-Ferre M; Herrington DM; Harada S; Eliassen H; Wang TJ; Gerszten RE; Albanes D; Tzoulaki I; Karaman I; Elliott P; Zhu HL; Wagenknecht LE; Zheng W; Cai H; Cai QY; Matthews CE; Menni C; Meyer KA; Lipworth LP; Ose J; Fornage M; Ulrich CM; Yu DX |
| Contributors: |
X. Pan; J. Yang; X. Shu; S. Moore; N. Palmer; M. Guasch-Ferre; D. Herrington; S. Harada; H. Eliassen; T. Wang; R. Gerszten; D. Albane; I. Tzoulaki; I. Karaman; P. Elliott; H. Zhu; L. Wagenknecht; W. Zheng; H. Cai; Q. Cai; C. Matthew; C. Menni; K. Meyer; L. Lipworth; J. Ose; M. Fornage; C. Ulrich; D. Yu |
| Publication Year: |
2021 |
| Collection: |
The University of Milan: Archivio Istituzionale della Ricerca (AIR) |
| Subject Terms: |
choline; betaine; carnitine; dimethylglycine; cardiometabolic disease; biomarkers; Settore MEDS-24/A - Statistica medica |
| Description: |
Background: Choline is an essential nutrient; however, the associations of choline and its related metabolites with cardiometabolic risk remain unclear. Objective: We examined the associations of circulating choline, betaine, carnitine, and dimethylglycine (DMG) with cardiometabolic biomarkers and their potential dietary and nondietary determinants. Methods: The cross-sectional analyses included 32,853 participants from 17 studies, who were free of cancer, cardiovascular diseases, chronic kidney diseases, and inflammatory bowel disease. In each study, metabolites and biomarkers were log-transformed and standardized by means and SDs, and linear regression coefficients (beta) and 95% CIs were estimated with adjustments for potential confounders. Study-specific results were combined by random-effects meta-analyses. A false discovery rate |
| Document Type: |
article in journal/newspaper |
| Language: |
English |
| Relation: |
info:eu-repo/semantics/altIdentifier/pmid/34020444; info:eu-repo/semantics/altIdentifier/wos/WOS:000704624600012; volume:114; issue:3; firstpage:893; lastpage:906; numberofpages:14; journal:THE AMERICAN JOURNAL OF CLINICAL NUTRITION; https://hdl.handle.net/2434/1097110 |
| DOI: |
10.1093/ajcn/nqab152 |
| Availability: |
https://hdl.handle.net/2434/1097110; https://doi.org/10.1093/ajcn/nqab152 |
| Rights: |
info:eu-repo/semantics/openAccess |
| Accession Number: |
edsbas.83145A99 |
| Database: |
BASE |