| Title: |
Non-Overt Coagulopathy in Non-ICU Patients with Mild to Moderate COVID-19 Pneumonia |
| Authors: |
Mazzaccaro, Daniela; Giacomazzi, Francesca; Giannetta, Matteo; Varriale, Alberto; Scaramuzzo, Rosa; Modafferi, Alfredo; Malacrida, Giovanni; Righini, Paolo; Marrocco-Trischitta, Massimiliano M; Nano, Giovanni |
| Contributors: |
D. Mazzaccaro; F. Giacomazzi; M. Giannetta; A. Varriale; R. Scaramuzzo; A. Modafferi; G. Malacrida; P. Righini; M.M. Marrocco-Trischitta; G. Nano |
| Publication Year: |
2020 |
| Collection: |
The University of Milan: Archivio Istituzionale della Ricerca (AIR) |
| Subject Terms: |
disseminated intravascular coagulation; DIC; COVID-19; respiratory distress; Settore MED/22 - Chirurgia Vascolare |
| Description: |
Introduction: Aim of the study is to assess the occurrence of early stage coagulopathy and disseminated intravascular coagulation (DIC) in patients with mild to moderate respiratory distress secondary to SARS-CoV-2 infection. Materials and methods: Data of patients hospitalized from 18 March 2020 to 20 April 2020 were retrospectively reviewed. Two scores for the screening of coagulopathy (SIC and non-overt DIC scores) were calculated. The occurrence of thrombotic complication, death, and worsening respiratory function requiring non-invasive ventilation (NIV) or admission to ICU were recorded, and these outcomes were correlated with the results of each score. Chi-square test, receiver-operating characteristic curve, and logistic regression analysis were used as appropriate.pValues < 0.05 were considered statistically significant. Results: Data of 32 patients were analyzed. Overt-DIC was diagnosed in two patients (6.2%), while 26 (81.2%) met the criteria for non-overt DIC. Non-overt DIC score values >= 4 significantly correlated with the need of NIV/ICU (p= 0.02) and with the occurrence of thrombotic complications (p= 0.04). A score >= 4 was the optimal cut-off value, performing better than SIC score (p= 0.0018). Values >= 4 in patients with thrombotic complications were predictive of death (p= 0.03). Conclusions: Overt DIC occurred in 6.2% of non-ICU patients hospitalized for a mild to moderate COVID-19 respiratory distress, while 81.2% fulfilled the criteria for non-overt DIC. The non-overt DIC score performed better than the SIC score in predicting the need of NIV/ICU and the occurrence of thrombotic complications, as well as in predicting mortality in patients with thrombotic complications, with a score >= 4 being detected as the optimal cut-off. |
| Document Type: |
article in journal/newspaper |
| Language: |
English |
| Relation: |
info:eu-repo/semantics/altIdentifier/pmid/32521707; info:eu-repo/semantics/altIdentifier/wos/WOS:000549313200001; volume:9; issue:6; firstpage:1; lastpage:12; numberofpages:12; journal:JOURNAL OF CLINICAL MEDICINE; https://hdl.handle.net/2434/769009 |
| DOI: |
10.3390/jcm9061781 |
| Availability: |
https://hdl.handle.net/2434/769009; https://doi.org/10.3390/jcm9061781 |
| Rights: |
info:eu-repo/semantics/openAccess |
| Accession Number: |
edsbas.8323974A |
| Database: |
BASE |