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Low-Grade Inflammation in Gestational Diabetes Mellitus and Its Correlation with Maternal Insulin Resistance and Fetal Growth Indices

Title: Low-Grade Inflammation in Gestational Diabetes Mellitus and Its Correlation with Maternal Insulin Resistance and Fetal Growth Indices
Authors: Xuan Nguyen K; Bui Minh T; Dinh HT; Viet Tran T; Dinh Le T; Phi Thi Nguyen N; Tran TTH; Hien Vu T; Ho Thi Nguyen L; Trung Nguyen K; Huy Thong N; Do K; Nguyen TK; Nguyen Dao H; Tien Nguyen S
Source: International Journal of General Medicine, Vol Volume 16, Pp 1429-1436 (2023)
Publisher Information: Dove Medical Press
Publication Year: 2023
Collection: Directory of Open Access Journals: DOAJ Articles
Subject Terms: gestational diabetes mellitus; low-grade inflammation; neutrophil-to-lymphocyte ratio; platelet-to-lymphocyte ratio; fetal ultrasound parameters; Medicine (General); R5-920
Description: Kien Xuan Nguyen,1,* Tien Bui Minh,2,* Hoa Trung Dinh,3,4 Tien Viet Tran,5 Tuan Dinh Le,5,* Nga Phi Thi Nguyen,6 Thi Thanh Hoa Tran,3 Trinh Hien Vu,3 Lan Ho Thi Nguyen,3 Kien Trung Nguyen,2 Nguyen Huy Thong,6 Khanh Do,6 Trung Kien Nguyen,7 Hung Nguyen Dao,8 Son Tien Nguyen6,* 1Department of Military Medical Command and Organization, Vietnam Medical Military University, Ha Noi, Vietnam; 2Department of Obstetrics and Gynecology, Thai Binh University of Medicine and Pharmacy, Thai Binh, Vietnam; 3Department of Requested Treatment, National Hospital of Endocrinology, Ha Noi, Vietnam; 4National Hospital of Endocrinology, Ha Noi, Vietnam; 5Department of Infectious Diseases, Military Hospital 103, Vietnam Medical Military University, Hanoi, Vietnam; 6Department of Rheumatology and Endocrinology, Military Hospital 103, Vietnam Military Medical University, Ha Noi, Vietnam; 7Hematology and Blood Transfusion Center, Military Hospital 103, Vietnam Military Medical University, Ha Noi, Vietnam; 8Department of Obstetrics and Gynecology, Military Hospital 103, Vietnam Military Medical University, Ha Noi, Vietnam*These authors contributed equally to this workCorrespondence: Son Tien Nguyen, Department of Rheumatology and Endocrinology, Military Hospital 103, Vietnam Military Medical University, 160 Phung Hung Street, Phuc La Ward, Ha Dong District, Hanoi City, Vietnam, Email ntson4879@gmail.comIntroduction: Chronic low-grade inflammation (LGI) plays a role in the pathogenesis of gestational diabetes mellitus (GDM). LGI, on the one hand, promotes insulin resistance and at the same time, affects fetal development. The study aimed to use clinically feasible means to evaluate the association between maternal LGI and maternal insulin resistance and fetal growth indices by ultrasound in the third trimester.Methods: A crossectional and descriptive study on 248 first-time diagnosed GDM in Vietnam.Results: Neutrophil-to-lymphocyte ratio (NLR) and platelet-to-lymphocyte (PLR) indices were significantly higher in GDM than in normal ...
Document Type: article in journal/newspaper
Language: English
Relation: https://www.dovepress.com/low-grade-inflammation-in-gestational-diabetes-mellitus-and-its-correl-peer-reviewed-fulltext-article-IJGM; https://doaj.org/toc/1178-7074; https://doaj.org/article/432b36edf383473abac842e27d669aec
Availability: https://doaj.org/article/432b36edf383473abac842e27d669aec
Accession Number: edsbas.833E4E1F
Database: BASE