| Title: |
Tricuspid Annular Plane Systolic Excursion/Systolic Pulmonary Artery Pressure Ratio and Cardiorenal Syndrome Type 2 in the Systemic Sclerosis EUSTAR Cohort |
| Authors: |
Colalillo, A.; Pellicano, C.; Ananyeva, L.P.; Hachulla, E.; Cuomo, G.; Györfi, A.; Czirják, L.; de Vries‐Bouwstra, J.; Mouthon, L.; Poormoghim, H.; Del Galdo, F.; Hunzelmann, N.; Spierings, J.; Kuwana, M.; Rosato, E. |
| Publisher Information: |
Wiley |
| Publication Year: |
2023 |
| Collection: |
White Rose Research Online (Universities of Leeds, Sheffield & York) |
| Description: |
Objective The aim of the study was to evaluate the association between the tricuspid annular plane systolic excursion (TAPSE)/systolic pulmonary artery pressure (sPAP) ratio and estimated glomerular filtration rate (eGFR) and their association with mortality in the European Scleroderma Trials and Research (EUSTAR) cohort. Methods Patients with systemic sclerosis (SSc) from the EUSTAR database with TAPSE, sPAP, and parameters required to calculate eGFR were included. Logistic regression and Cox regression analysis were performed to evaluate TAPSE/sPAP as a risk factor for chronic kidney disease (CKD) and overall survival. Results A total of 2,370 patients with SSc were included; 284 (12%) patients had CKD stage 3a–5. TAPSE/sPAP (odds ratio [OR] 0.479; 95% CI 0.310–0.743; P < 0.001), arterial hypertension (OR 3.118; 95% CI 2.173–4.475; P < 0.001), diastolic dysfunction (OR 1.670; 95% CI 1.148–2.428; P < 0.01), and N-terminal pro-B-type natriuretic peptide (OR 1.165; 95% CI 1.041–1.304; P < 0.01) were associated with CKD stage 3a–5. TAPSE/sPAP ≤0.32 mm/mm Hg (hazard ratio [HR] 3.589; 95% CI 2.236–5.761; P < 0.001), eGFR |
| Document Type: |
article in journal/newspaper |
| File Description: |
text |
| Language: |
English |
| ISSN: |
2151-464X |
| Relation: |
https://eprints.whiterose.ac.uk/id/eprint/205345/1/Arthritis%20Care%20%20%20Research%20-%202023%20-%20Colalillo%20-%20Tricuspid%20Annular%20Plane%20Systolic%20Excursion%20Systolic%20Pulmonary%20Artery.pdf; Colalillo, A., Pellicano, C., Ananyeva, L.P. et al. (12 more authors) (2023) Tricuspid Annular Plane Systolic Excursion/Systolic Pulmonary Artery Pressure Ratio and Cardiorenal Syndrome Type 2 in the Systemic Sclerosis EUSTAR Cohort. Arthritis Care & Research. ISSN: 2151-464X |
| Availability: |
https://eprints.whiterose.ac.uk/id/eprint/205345/ |
| Rights: |
cc_by_nc_nd_4 |
| Accession Number: |
edsbas.83689FA2 |
| Database: |
BASE |