| Title: |
Sex differences in post-acute neurological sequelae of SARS-CoV-2 and symptom resolution in adults after COVID-19 hospitalization: an international multicenter prospective observational study |
| Authors: |
Cho, S-M; Premraj, L; Battaglini, D; Fanning, JP; Suen, J; Bassi, GL; Fraser, J; Robba, C; Griffee, M; Solomon, T; Semple, MG; Baillie, K; Sigfrid, L; Scott, JT; Citarella, BW; Merson, L; Arora, RC; Whitman, G; Thomson, D; White, N; Abel, L; Abrous, A; Jabal, KA; Zayyad, HA; Tamlihat, YA; Alameen, AM; Alessi, M; Alex, B; Alexandre, K; Ali, A; Alidjnou, KE; Allavena, C; Allou, N; Andréjak, C; Angheben, A; Angoulvant, F; Ansart, S; Arlet, J-B; Artaud-Macari, E; Assie, JB; Auchabie, J; Aumaitre, H; Auvet, A; Axelsen, EW; Azemar, L; Azoulay, C; Bach, B; Bachelet, D; Bævre-Jensen, R; Badr, C |
| Contributors: |
Group, ISARIC Clinical Characterisation |
| Publisher Information: |
Oxford University Press |
| Publication Year: |
2024 |
| Collection: |
Oxford University Research Archive (ORA) |
| Description: |
Although it is known that coronavirus disease 2019 can present with a range of neurological manifestations and in-hospital complications, sparse data exist on whether these initial neurological symptoms of coronavirus disease 2019 are closely associated with post-acute neurological sequelae of SARS-CoV-2 (severe acute respiratory syndrome coronavirus 2; PANSC) and whether female versus male sex impacts symptom resolution. In this international, multi-centre, prospective, observational study across 407 sites from 15 countries (30 January 2020 to 30 April 2022), we report the prevalence and risk factors of PANSC among hospitalized adults and investigate the differences between males and females on neurological symptom resolution over time. PANSC symptoms included altered consciousness/confusion, fatigue/malaise, anosmia, dysgeusia and muscle ache/joint pain, on which information was collected at index hospitalization and during follow-up assessments. The analysis considered a time to the resolution of individual and all neurological symptoms. The resulting times were modelled by Weibull regression, assuming mixed-case interval censoring, with sex and age included as covariates. The model results were summarized as cumulative probability functions and age-adjusted and sex-adjusted median times to resolution. We included 6862 hospitalized adults with coronavirus disease 2019, who had follow-up assessments. The median age of the participants was 57 years (39.2% females). Males and females had similar baseline characteristics, except that more males (versus females) were admitted to the intensive care unit (30.5 versus 20.3%) and received mechanical ventilation (17.2 versus 11.8%). Approximately 70% of patients had multiple neurological symptoms at the first follow-up (median = 102 days). Fatigue (49.9%) and myalgia/arthralgia (45.2%) were the most prevalent symptoms of PANSC at the initial follow-up. The reported prevalence in females was generally higher (versus males) for all symptoms. At 12 months, anosmia and ... |
| Document Type: |
article in journal/newspaper |
| Language: |
English |
| Relation: |
https://doi.org/10.1093/braincomms/fcae036 |
| DOI: |
10.1093/braincomms/fcae036 |
| Availability: |
https://doi.org/10.1093/braincomms/fcae036; https://ora.ox.ac.uk/objects/uuid:dee769f0-8a07-42e3-be4d-7a10f1ae1b86 |
| Rights: |
info:eu-repo/semantics/openAccess ; CC Attribution (CC BY) |
| Accession Number: |
edsbas.836B4BB4 |
| Database: |
BASE |