| Title: |
Assessment of nodal staging and risk factors for nodal involvement in gallbladder cancer |
| Authors: |
Balakrishnan, Anita; Barmpounakis, Petros; Demiris, Nikolaos; Andersson, Bodil; Brañes, Alejandro; de Aretxabala, Xavier; Eilard, Malin Sternby; Gibbs, Paul; Harper, Simon J F; Huguet, Emmanuel L; Jah, Asif; Kosmoliaptsis, Vasilis; Lendoire, Javier; Liau, Siong S; Maithel, Shishir; Martin, Jack L; Noel, Colin; Praseedom, Raaj K; Serrablo, Alejandro; Adsay, Volkan; Abe, Tomoyuki; Abu Hilal, Moh'd; del Mar Achalandabaso Boira, Maria; Adham, Mustapha; Adam, Mohamed; Ahmad, Maryam; Al-Sarireh, Bilal; Albiol, Maite; Alhaboob, Nassir; Alseidi, Adnan; Ammar, Houssem; Anand, Akshay; Antonakis, Pantelis; Araya, Veronica; Ashley, Stanley W; Atanasov, Georgi; Ausania, Fabio; Balestri, Ricardo; Banerjee, Abhirup; Banerjee, Sudeep; Banting, Simon; Barauskas, Giedrius; Bartsch, Fabian; Belli, Andrea; Beretta, Simona; Berrevoet, Frederik; Bhandari, Ramesh Singh; Fernandez, Gerardo Blanco; Bolm, Louisa; Bonal, Mathieu; Bozkurt, Emre; Braat, Andries E; Bradshaw, Luke; Bramis, Konstantinos; Branes, Alejandro; Burdine, Lyle; Byrne, Matthew; Caceres, Maria; Santiago, Maria Jesus Castro; Chan, Benjamin; Chong, Lynn; Çoker, Ahmet; Rodriguez, Maria Conde; Croagh, Daniel; Crutchley, Alyn; Cutolo, Carmen; D'Hondt, Mathieu; D'Souza, Daniel; Daams, Freek; Valle, Raffaele Dalla; Davide, José; de Bellis, Mario; de Boer, Marieke; de Meyere, Celine; de Reuver, Philip; Dixon, Matthew; Dorovinis, Panagiotis; Bauer, Gabriela Echeverría; Eduarda, Maria; Eker, Hasan; Erdmann, Joris; Erkan, Mert; Felekouras, Evangelos; Felli, Emanuele; Fernandes, Eduardo; Rivera, Eduardo Figueroa; Fulop, Andras; Galun, Daniel; Gerhards, Michael; Ghorbani, Poya; Giannone, Fabio; Gil, Luis; Giorgakis, Emmanouil; Giuffrida, Mario; Giuliante, Felice; Gkekas, Ioannis; Bravo, Miguel Gomez; Koerkamp, Bas Groot; Guevara, Oscar; Guglielmi, Alfredo; Gulla, Aiste; Gupta, Rahul; Gupta, Amit; Gutiérrez, Marta; Bhatti, Abu Bakar Hafeez; Hagendoorn, Jeroen; Hajee, Zain; Hakeem, Abdul Rahman; Hamid, Hytham; Hassen, Sayed; Heinrich, Stefan; Hernandez-Alejandro, Roberto; Higuchi, Ryota; Hoffman, Daniel; Holroyd, David; Hughes, Daniel; Ivanecz, Arpad; Iype, Satheesh; Torrejimeno, Isabel Jaen; Joglekar, Shantanu; Jones, Robert; Kaczirek, Klaus; Kanhere, Harsh; Kausar, Ambareen; Kee, Zhanyi; Keilson, Jessica; Kleef, Jorg; Klose, Johannes; Knowles, Brett; Koong, Jun Kit; Kumar, Nagappan; Kunnuru, Supreeth; Lakhey, Paleswan Joshi; Laurenzi, Andrea; Lee, Yeong Sing; Leon, Felipe; Leow, Voon Meng; Lequeu, Jean-Baptiste; Lesurtel, Mickael; Lo, Elisabeth; Löb, Stefan; Lockie, Elizabeth; Lodge, Peter; Garnica, Dolores López; Lopez, Victor Lopez; Lundgren, Linda; Machairas, Nikolaos; Maharjan, Dhiresh; Malde, Deep; Mankarious, Marc; Martel, Guillaume; Martin, Julie; Mazzola, Michele; Mehrabi, Arianeb; Memeo, Ricardo; Milana, Flavio; Molina, George; Monette, Leah; Morgul, Haluk; Moris, Dimitrios; Morsi-Yeroyannis, Antonios; Mowbray, Nicholas; Mulita, Francesk; Muttillo, Edoardo Maria; Nandasena, Malith; Nashidengo, Pueya Rashid; Nickkholgh, Arash; Noel, Colin Byron; Ohtsuka, Masayuki; Ozolins, Arturs; Pandanaboyana, Sanjay; Pararas, Nikolaos; Parente, Alessandro; Peng, June; Valero, Arkaitz Perfecto; Perinel, Julie; Perivoliotis, Konstatinos; Perra, Teresa; Pessaux, Patrick; Petruch, Natalie; Piccolo, Gaetano; Piros, Laszlo; Porcu, Alberto; Prabakaran, Viswakumar; Prasad, Raj; Calvo, Mikel Prieto; Primavesi, Florian; Periz, Eva Maria Pueyo; Quaglia, Alberto; Angel, Jose M Ramia; Rammohan, Ashwin; Razionale, Francesco; Campos, Ricardo Robles; Roy, Manas; Rozwadowski, Sophie; Ruffolo, Luis; Ruiz, Natalia; Ruzzenante, Andrea; Saadat, Lily; Said, Mohamed Amine; Saladino, Edoardo; Saliba, Gabriel; Sandstrom, Per; Schena, Carlo Alberto; Scholer, Anthony; Schwarz, Christoph; Serafini, Lorenzo; Serrablo, Leyre; Serrano, Pablo E; Sharma, Deepak; Sheen, Aali; Siddagangaiah, Vishwanath; Silva, Michael; Singh, Saurabh; Siriwardena, Ajith; Skalski, Michal; Smig, Mante; Soliman, Faris; Sonkar, Abhinav Arun; Silva, Donzília Sousa; Sparrelid, Ernesto; Spiers, Harry V M; Srinivasan, Parthi; Strobel, Oliver; Stupan, Urban; Suarez-Munoz, Miguel Angel; Subramaniam, Manisekar; Sugiura, Teiichi; Sutcliffe, Robert; Swank, Hilko; Talukder, Shibojit; Taylor, Lillian; Thapa, Prabin Bikram; Teh, Catherine; Thepbunchonchai, Asara; Thieu, Caman; Tiwari, Navneet; Torzilli, Guido; Tovikkai, Chutwichai; Trotovsek, Blaz; Tsaramanidis, Savvas; Tsoulfas, Georgios; Uesaka, Katsuhiko; Umar, Garzali; Urbani, Lucio; Vailas, Michail; van Dam, Ronald; van de Boezem, Peter; van Laarhoven, Stijn; Vanagas, Tomas; Van Dooren, Mike; Viennet, Manon; Vigano, Luca; Vijayashanker, Aarathi; Villodre, Celia; Wakai, Toshifumi; Workneh, Aklile; Xu, Li; Yamamoto, Masakazu; Yang, Zhiying; Young, Robert; Zivanovic, Marko; OMEGA Study Investigators, missing |
| Source: |
BJS OPEN ; ISSN: 2474-9842 |
| Publication Year: |
2025 |
| Collection: |
Ghent University Academic Bibliography |
| Subject Terms: |
Medicine and Health Sciences; BILE-DUCT RESECTION; PROGNOSTIC IMPLICATIONS; SURGICAL-MANAGEMENT; SURGERY; SURVIVAL; IMPACT |
| Description: |
Background Nodal assessment in gallbladder cancer remains challenging, particularly in incidental gallbladder cancer. This understages the number of patients with node-positive disease, resulting in prognostic inaccuracy and insufficient adjuvant treatment. This study aimed to identify risk factors for positive nodes in gallbladder cancer and to compare prognostic discrimination of available nodal staging parameters. Methods This international cohort study assessed gallbladder cancer resections undertaken between 1 January 2010 and 31 December 2020. Logistic regression was used to identify risk factors for node-positive status and develop a risk prediction score for positive nodes. Nodal staging models, including nodal site, number of positive nodes, and positive node ratio were compared for greatest prognostic discrimination in gallbladder cancer. Results A total of 3676 patients underwent gallbladder cancer resection across 133 centres in 41 countries. Tumour (T) stage (T2, P = 0.012; T3, P = 0.002; and T4, P < 0.001), lymphovascular and perineural infiltration (P < 0.001), and tumour differentiation (P < 0.001) carried the greatest risk of positive nodes. These three parameters comprised the OMEGA Node Positivity Prediction Score (OMEGA-NOPPS) with C-statistics of 0.81 (95% confidence interval 0.78 to 0.84) in the training data set and 0.79 (0.73 to 0.85) in the test data set for identification of node-positive status, highlighting a >= 20% increased risk of positive nodes in poorly differentiated tumours with lymphovascular and perineural infiltration despite T1 disease. Conclusion Data from this large multicentre study confirmed that the number of positive nodes is the most discriminative prognostic model for nodal staging in gallbladder cancer. OMEGA-NOPPS provides three simple parameters to stratify nodal involvement according to risk. Incidental gallbladder cancer with lymphovascular and perineural infiltration and poorly differentiated tumours, including early T stages, should be considered ... |
| Document Type: |
article in journal/newspaper |
| File Description: |
application/pdf |
| Language: |
English |
| Relation: |
https://biblio.ugent.be/publication/01KJ7Y5WTXGKWWSBVAGP4Q3TWZ; https://doi.org/10.1093/bjsopen/zraf056; https://biblio.ugent.be/publication/01KJ7Y5WTXGKWWSBVAGP4Q3TWZ/file/01KJ7Y6PAF0S8GJV5VKH3E2CQP |
| DOI: |
10.1093/bjsopen/zraf056 |
| Availability: |
https://biblio.ugent.be/publication/01KJ7Y5WTXGKWWSBVAGP4Q3TWZ; https://hdl.handle.net/1854/LU-01KJ7Y5WTXGKWWSBVAGP4Q3TWZ; https://doi.org/10.1093/bjsopen/zraf056; https://biblio.ugent.be/publication/01KJ7Y5WTXGKWWSBVAGP4Q3TWZ/file/01KJ7Y6PAF0S8GJV5VKH3E2CQP |
| Rights: |
info:eu-repo/semantics/openAccess |
| Accession Number: |
edsbas.83E9B786 |
| Database: |
BASE |