| Title: |
Selective Blood Cell Hitchhiking in Whole Blood with Ionic Liquid-Coated PLGA Nanoparticles to Redirect Biodistribution After Intravenous Injection |
| Authors: |
Hamadani, Christine M.; Dasanayake, Gaya S.; Chism, Claylee M.; Gorniak, Meghan E.; Monroe, Wake G.; Merrell, Anya; Pride, Mercedes C.; Heintz, Rebekah; Wong, Karen; Hossain, Mehjabeen; Taylor, George; Edgecomb, Sara X.; Jones, Deauntaye; Dhar, Joy; Banka, Alison; Singh, Gagandeep; Vashisth, Priyavrat; Randall, Joh'nis; Darlington, Donovan S.; Everett, Jaylon; Jarrett, Ethan; Werfel, Thomas A.; Eniola-Adefeso, Omolola; Tanner, Eden E. L. |
| Publisher Information: |
Springer Science and Business Media LLC |
| Publication Year: |
2023 |
| Description: |
Less than 5% of intravenously-injected nanoparticles (NPs) reach destined sites in the body due to opsonization and immune-based clearance in vascular circulation. By hitchhiking in situ onto specific blood components post-injection, NPs can selectively target tissue sites for unprecedentedly high drug delivery rates . Choline carboxylate ionic liquids (ILs) are biocompatible liquid salts |
| Document Type: |
other/unknown material |
| Language: |
unknown |
| DOI: |
10.21203/rs.3.rs-3146716/v1 |
| Availability: |
https://doi.org/10.21203/rs.3.rs-3146716/v1; https://www.researchsquare.com/article/rs-3146716/v1; https://www.researchsquare.com/article/rs-3146716/v1.html |
| Rights: |
https://creativecommons.org/licenses/by/4.0/ |
| Accession Number: |
edsbas.83F07940 |
| Database: |
BASE |