| Title: |
Pulmonary Function and Blood DNA Methylation A Multiancestry Epigenome-Wide Association Meta-analysis |
| Authors: |
Lee, Mikyeong; Huan, Tianxiao; McCartney, Daniel; Chittoor, Geetha; de Vries, Maaike; Lahousse, Lies; Nguyen, Jennifer N.; Body, Jennifer; Castillo-Fernandez, Juan; Terzikhan, Natalie; Qi, Cancan; Joehanes, Roby; Min, Josine; Smilnak, Gordon J.; Shaw, Jessica R; Yang, Chen Xi; Colicino, Elena; Hoang, Thanh T.; Bermingham, Mairead L.; Xu, Hanfei; Justice, Anne E.; Xu, Chengjian; Rich, Stephen; Cox, Simon R.; Vonk, Judith M.; Prokic (Nedeljkovic), Ivana; Sotoodehnia, Nona; TSAI, PEI-CHIEN; Schwartz, Joel; Leung, Janice M.; Sikdar, Sinjini; Walker, Rosie M.; Harris, Sarah; van der Plaat, Diana A.; Van Den Berg, David J; Bartz, Traci M. Bartz; Spector, Tim D.; Vokonas, Pantel S.; Marioni, Riccardo; Taylor, Adele M.; Liu, Yongmei; Barr, Graham R.; Lange, Leslie; Baccarelli, Andrea A.; Obeidat, Ma'en; Fornage, Myriam; WANG, TIANYUAN; Ward, James M.; Motsinger-Reif, Alison; Hemani, Gibran; Koppelman, Gerard; Bell, Jordana; GHARIB, SINA A.; Brusselle, Guy; Boezen, H. Marike; North, Kari; Levy, Daniel; Evans, Kathryn; Dupuis, Josee; Breeze, Charles; Manichaikul, Ani; London, Stephanie; Biobank-based Integrative Omics Study (BIOS) Consortium; Genetics of DNA Methylation Consortium (GoDMC) |
| Source: |
American journal of respiratory and critical care medicine, 206(3):321-336 |
| Publication Year: |
2022 |
| Collection: |
Publisso (ZB MED-Publikationsportal Lebenswissenschaften) |
| Subject Terms: |
chronic obstructive pulmonary disease; spirometry; epigenetics; respiratory function tests |
| Description: |
RATIONALE: Methylation integrates factors present at birth and modifiable across the lifespan that can influence pulmonary function. Studies are limited in scope and replication. OBJECTIVES: To conduct large-scale epigenome-wide meta-analyses of blood DNA methylation and pulmonary function. METHODS: Twelve cohorts analyzed associations of methylation at cytosine-phosphate-guanine probes (CpGs), using Illumina 450K or EPIC/850K arrays, with FEV1, FVC, and FEV1/FVC. We performed multiancestry epigenome-wide meta-analyses (total of 17,503 individuals; 14,761 European, 2,549 African, and 193 Hispanic/Latino ancestries) and interpreted results using integrative epigenomics. MEASUREMENTS AND MAIN RESULTS: We identified 1,267 CpGs (1,042 genes) differentially methylated (false discovery rate, |
| Document Type: |
article in journal/newspaper |
| Language: |
English |
| Relation: |
https://repository.publisso.de/resource/frl:6435470; https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9890261/ |
| DOI: |
10.1164/rccm.202108-1907OC |
| Availability: |
https://repository.publisso.de/resource/frl:6435470; https://doi.org/10.1164/rccm.202108-1907OC; https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9890261/; https://www.atsjournals.org/doi/suppl/10.1164/rccm.202108-1907OC |
| Rights: |
https://creativecommons.org/licenses/by-nc-nd/4.0/ |
| Accession Number: |
edsbas.83F75118 |
| Database: |
BASE |