| Title: |
Prevalence of gyrA , gyrB , parC , and parE Mutations in Clinical Isolates of Streptococcus pneumoniae with Decreased Susceptibilities to Different Fluoroquinolones and Originating from Worldwide Surveillance Studies during the 1997-1998 Respiratory Season |
| Authors: |
Jones, Mark E.; Sahm, Daniel F.; Martin, Nele; Scheuring, Sibylle; Heisig, Peter; Thornsberry, Clyde; Köhrer, Karl; Schmitz, Franz-Josef |
| Source: |
Antimicrobial Agents and Chemotherapy ; volume 44, issue 2, page 462-466 ; ISSN 0066-4804 1098-6596 |
| Publisher Information: |
American Society for Microbiology |
| Publication Year: |
2000 |
| Description: |
From 8,419 worldwide clinical isolates of Streptococcus pneumoniae obtained during 1997-1998, 69 isolates with reduced susceptibility or resistance to fluoroquinolones (FQs) were molecularly characterized. For the isolates in this prevalence study, only parC (Ser-79→Tyr) and gyrA (Ser-81→Phe or Tyr) mutations, especially in combination, were found to contribute significantly to resistance. These mutations influenced the FQ MICs to varying degrees, although the rank order of activity remains independent of mutation type, with ciprofloxacin the least active, followed by levofloxacin, gatifloxacin/grepafloxacin/moxifloxacin/sparfloxacin/trovafloxacin, and clinafloxacin/sitafloxacin. Efflux likely plays a crucial role in reduced susceptibility for new hydrophilic FQs. |
| Document Type: |
article in journal/newspaper |
| Language: |
English |
| DOI: |
10.1128/aac.44.2.462-466.2000 |
| DOI: |
10.1128/AAC.44.2.462-466.2000 |
| Availability: |
https://doi.org/10.1128/aac.44.2.462-466.2000; https://journals.asm.org/doi/pdf/10.1128/AAC.44.2.462-466.2000 |
| Rights: |
https://journals.asm.org/non-commercial-tdm-license |
| Accession Number: |
edsbas.840BFAC7 |
| Database: |
BASE |