| Title: |
Long term health outcomes in people with diabetes 12 months after hospitalisation with COVID-19 in the UK: a prospective cohort study |
| Authors: |
Gharibzadeh, Safoora; Routen, Ash; Razieh, Cameron; Zaccardi, Francesco; Lawson, Claire; Gillies, Clare; Heller, Simon; Davies, Melanie; Atkins, Helen; Bain, Stephen C; Lone, Nazir L; Poinasamy, Krisnah; Peto, Tunde; Robertson, Elizabeth; Young, Bob; Johnston, Desmond; Quint, Jennifer; Valabhji, Jonathan; Ismail, Khalida; Marks, Michael; Horsley, Alex; Docherty, Annemarie; Harrison, Ewen; Chalmers, James; Ho, Ling-Pei; Raman, Betty; Brightling, Chris; Elneima, Omer; Evans, Rachel; Greening, Neil; Harris, Victoria C; Houchen-Wolloff, Linzy; Sereno, Marco; Shikotra, Aarti; Singapuri, Amisha; Wain, Louise; Langenberg, Claudia; Dennis, John; Petrie, John; Sattar, Naveed; Leavy, Olivia; Richardson, Mattew; Saunders, Ruth M.; McArdle, Anne; McASuley, Hamish; Yates, Tom; Khunti, Kamlesh; PHOSP-COVID Study Collaborative Group, . |
| Publisher Information: |
Elsevier |
| Publication Year: |
2025 |
| Collection: |
University of Glasgow: Enlighten - Publications |
| Description: |
Background: People with diabetes are at increased risk of hospitalisation, morbidity, and mortality following SARS-CoV-2 infection. Long-term outcomes for people with diabetes previously hospitalised with COVID-19 are, however, unknown. This study aimed to determine the longer-term physical and mental health effects of COVID-19 in people with and without diabetes. Methods: The PHOSP-COVID study is a multicentre, long-term follow-up study of adults discharged from hospital between 1 February 2020 and 31 March 2021 in the UK following COVID-19, involving detailed assessment at 5 and 12 months after discharge. The association between diabetes status and outcomes were explored using multivariable linear and logistic regressions. Findings: People with diabetes who survived hospital admission with COVID-19 display worse physical outcomes compared to those without diabetes at 5- and 12-month follow-up. People with diabetes displayed higher fatigue (only at 5 months), frailty, lower physical performance, and health-related quality of life and poorer cognitive function. Differences in outcomes between diabetes status groups were largely consistent from 5 to 12-months. In regression models, differences at 5 and 12 months were attenuated after adjustment for BMI and presence of other long-term conditions. Interpretation: People with diabetes reported worse physical outcomes up to 12 months after hospital discharge with COVID-19 compared to those without diabetes. These data support the need to reduce inequalities in long-term physical and mental health effects of SARS-CoV-2 infection in people with diabetes. |
| Document Type: |
article in journal/newspaper |
| File Description: |
text |
| Language: |
English |
| Relation: |
https://eprints.gla.ac.uk/346841/1/346841.pdf; Gharibzadeh, S. et al. (2025) Long term health outcomes in people with diabetes 12 months after hospitalisation with COVID-19 in the UK: a prospective cohort study. EClinicalMedicine , 79, 103005. (doi:10.1016/j.eclinm.2024.103005 ) (PMID:39834716) (PMCID:PMC11743801) |
| DOI: |
10.1016/j.eclinm.2024.103005 |
| Availability: |
https://eprints.gla.ac.uk/346841/; https://eprints.gla.ac.uk/346841/1/346841.pdf; https://doi.org/10.1016/j.eclinm.2024.103005 |
| Rights: |
cc_by_4 |
| Accession Number: |
edsbas.843BB442 |
| Database: |
BASE |