| Title: |
Adenovirus vectors activate Vδ2+ γδT cells in a type I interferon-, TNF-, and IL-18-dependent manner |
| Authors: |
Provine, NM; Amini, A; Garner, LC; FitzPatrick, MEB; Dold, C; Reyes, LS; Chinnakannan, S; Oguti, B; Raymond, M; Troise, F; Capone, S; Folgori, A; Barnes, E; Rollier, CS; Pollard, AJ; Klenerman, P |
| Publisher Information: |
Wiley |
| Publication Year: |
2022 |
| Collection: |
Oxford University Research Archive (ORA) |
| Description: |
Vδ2+ γδT cells are unconventional T cells that can be activated by cytokines without TCR signaling. Adenovirus vaccine vectors activated Vδ2+ γδT cells in an interleukin 18-, TNF-, and type I interferon-dependent manner. This stimulatory capacity was associated with adenovirus vectors of non-species C origin, including the ChAdOx1 vaccine platform. |
| Document Type: |
article in journal/newspaper |
| Language: |
English |
| Relation: |
https://doi.org/10.1002/eji.202149367 |
| DOI: |
10.1002/eji.202149367 |
| Availability: |
https://doi.org/10.1002/eji.202149367; https://ora.ox.ac.uk/objects/uuid:f4fe332c-d4ad-4bd1-b404-9da390118a84 |
| Rights: |
info:eu-repo/semantics/openAccess ; CC Attribution (CC BY) |
| Accession Number: |
edsbas.84509F03 |
| Database: |
BASE |