| Title: |
Stanniocalcin-2 inhibits skeletal muscle growth and is upregulated in functional overload-induced hypertrophy. |
| Authors: |
Lionikas, A; Hernandez Cordero, AI; Kilikevicius, A; Carroll, AM; Bewick, GS; Bunger, L; Ratkevicius, A; Heisler, LK; Harboe, M; Oxvig, C |
| Publisher Information: |
Wiley Open Access |
| Publication Year: |
2023 |
| Collection: |
Queen Mary University of London: Queen Mary Research Online (QMRO) |
| Subject Terms: |
IGF; STC2; resistance training; skeletal muscle; Animals; Mice; Glycoproteins; Hypertrophy; Insulin-Like Growth Factor Binding Protein 4; Insulin-Like Growth Factor I; Muscle; Skeletal; Peptide Hormones; Pregnancy-Associated Plasma Protein-A |
| Description: |
AIMS: Stanniocalcin-2 (STC2) has recently been implicated in human muscle mass variability by genetic analysis. Biochemically, STC2 inhibits the proteolytic activity of the metalloproteinase PAPP-A, which promotes muscle growth by upregulating the insulin-like growth factor (IGF) axis. The aim was to examine if STC2 affects skeletal muscle mass and to assess how the IGF axis mediates muscle hypertrophy induced by functional overload. METHODS: We compared muscle mass and muscle fiber morphology between Stc2-/- (n = 21) and wild-type (n = 15) mice. We then quantified IGF1, IGF2, IGF binding proteins -4 and -5 (IGFBP-4, IGFBP-5), PAPP-A and STC2 in plantaris muscles of wild-type mice subjected to 4-week unilateral overload (n = 14). RESULTS: Stc2-/- mice showed up to 10% larger muscle mass compared with wild-type mice. This increase was mediated by greater cross-sectional area of muscle fibers. Overload increased plantaris mass and components of the IGF axis, including quantities of IGF1 (by 2.41-fold, p = 0.0117), IGF2 (1.70-fold, p = 0.0461), IGFBP-4 (1.48-fold, p = 0.0268), PAPP-A (1.30-fold, p = 0.0154) and STC2 (1.28-fold, p = 0.019). CONCLUSION: Here we provide evidence that STC2 is an inhibitor of muscle growth upregulated, along with other components of the IGF axis, during overload-induced muscle hypertrophy. |
| Document Type: |
article in journal/newspaper |
| File Description: |
e15793 - ? |
| Language: |
English |
| Relation: |
Physiol Rep; https://qmro.qmul.ac.uk/xmlui/handle/123456789/97072 |
| DOI: |
10.14814/phy2.15793 |
| Availability: |
https://qmro.qmul.ac.uk/xmlui/handle/123456789/97072; https://doi.org/10.14814/phy2.15793 |
| Rights: |
This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited. ; © 2023 The Authors. Physiological Reports published by Wiley Periodicals LLC on behalf of The Physiological Society and the American Physiological Society. |
| Accession Number: |
edsbas.8453248C |
| Database: |
BASE |