| Title: |
Triostin A Derived Cyclopeptide as Architectural Template for the Alignment of Four Recognition Units |
| Authors: |
Kotyrba, Ursula M.; Proepper, Kevin; Sachs, Eike-F.; Myanovska, Anastasiya; Joppe, Tobias; Lissy, Friederike; Sheldrick, George M.; Koszinowski, Konrad; Diederichsen, Ulf |
| Contributors: |
Kotyrba, Ursula M.; Proepper, Kevin; Sachs, Eike-F.; Myanovska, Anastasiya; Joppe, Tobias; Lissy, Friederike; Sheldrick, George M.; Koszinowski, Konrad; Diederichsen, Ulf |
| Publisher Information: |
Wiley-v C H Verlag Gmbh |
| Publication Year: |
2014 |
| Collection: |
Georg-August-Universität Göttingen: GoeScholar |
| Description: |
The DNA bisintercalator triostin A is structurally based on a disulfide-bridged depsipeptide scaffold that provides preorganization of two quinoxaline units in 10.5 angstrom distance. Triostin A analogues are synthesized with nucleobase recognition units replacing the quinoxalines and containing two additional recognition units in between. Thus, four nucleobase recognition units are organized on a rigid template, well suited for DNA double strand interactions. The new tetra-nucleobase binders are synthesized as aza-TANDEM derivatives lacking the N-methylation of triostin A and based on a cyclopeptide backbone. Synthesis of two tetra-nucleobase aza-TANDEM derivatives is established, DNA interaction analyzed by microscale thermophoresis, cytotoxic activity studied and a nucleobase sequence dependent self-aggregation investigated by mass spectrometry. ; Deutsche Forschungsgemeinschaft [DI 542/7-1, SH 14/5-1] |
| Document Type: |
article in journal/newspaper |
| Language: |
unknown |
| ISSN: |
25478311 |
| Relation: |
000341175700005 |
| DOI: |
10.1002/open.201400001 |
| Availability: |
https://resolver.sub.uni-goettingen.de/purl?gro-2/32739; https://resolver.sub.uni-goettingen.de/purl?gs-1/11914; https://doi.org/10.1002/open.201400001 |
| Rights: |
info:eu-repo/semantics/openAccess ; CC BY-NC 3.0 ; https://creativecommons.org/licenses/by-nc/3.0 |
| Accession Number: |
edsbas.849CBAE9 |
| Database: |
BASE |