| Title: |
Use of the Instantaneous Wave-free Ratio or Fractional Flow Reserve in PCI |
| Authors: |
Davies, JE; Sen, S; Dehbi, H-M; Al-Lamee, R; Petraco, R; Nijjer, SS; Bhindi, R; Lehman, SJ; Walters, D; Sapontis, J; Janssens, L; Vrints, CJ; Khashaba, A; Laine, M; Van Belle, E; Krackhardt, F; Bojara, W; Going, O; Härle, T; Indolfi, C; Niccoli, G; Ribichini, F; Tanaka, N; Yokoi, H; Takashima, H; Kikuta, Y; Erglis, A; Vinhas, H; Silva, PC; Baptista, SB; Alghamdi, A; Hellig, F; Koo, B-K; Nam, C-W; Shin, E-S; Doh, J-H; Brugaletta, S; Alegria-Barrero, E; Meuwissen, M; Piek, JJ; van Royen, N; Sezer, M; Di Mario, C; Gerber, RT; Malik, IS; Sharp, ASP; Talwar, S; Tang, K; Samady, H; Altman, J; Seto, AH; Singh, J; Jeremias, A; Matsuo, H; Kharbanda, RK; Patel, MR; Serruys, P; Escaned, J |
| Source: |
New England Journal of Medicine , 376 (19) pp. 1824-1834. (2017) |
| Publisher Information: |
MASSACHUSETTS MEDICAL SOC |
| Publication Year: |
2017 |
| Collection: |
University College London: UCL Discovery |
| Description: |
BACKGROUND: Coronary revascularization guided by fractional flow reserve (FFR) is associated with better patient outcomes after the procedure than revascularization guided by angiography alone. It is unknown whether the instantaneous wave-free ratio (iFR), an alternative measure that does not require the administration of adenosine, will offer benefits similar to those of FFR. METHODS: We randomly assigned 2492 patients with coronary artery disease, in a 1:1 ratio, to undergo either iFR-guided or FFR-guided coronary revascularization. The primary end point was the 1-year risk of major adverse cardiac events, which were a composite of death from any cause, nonfatal myocardial infarction, or unplanned revascularization. The trial was designed to show the noninferiority of iFR to FFR, with a margin of 3.4 percentage points for the difference in risk. RESULTS: At 1 year, the primary end point had occurred in 78 of 1148 patients (6.8%) in the iFR group and in 83 of 1182 patients (7.0%) in the FFR group (difference in risk, −0.2 percentage points; 95% confidence interval [CI], −2.3 to 1.8; P |
| Document Type: |
article in journal/newspaper |
| File Description: |
text |
| Language: |
English |
| Relation: |
https://discovery.ucl.ac.uk/id/eprint/10057346/ |
| Availability: |
https://discovery.ucl.ac.uk/id/eprint/10057346/1/Dehbi_Use%20of%20the%20Instantaneous%20Wave-free%20Ratio%20or%20Fractional%20Flow%20Reserve%20in%20PCI_VoR.pdf; https://discovery.ucl.ac.uk/id/eprint/10057346/ |
| Rights: |
open |
| Accession Number: |
edsbas.84A3DE0A |
| Database: |
BASE |