| Title: |
Association of pre-pandemic high-density lipoprotein cholesterol with risk of COVID-19 hospitalisation and death: The UK Biobank cohort study |
| Authors: |
Lassale, C; Hamer, M; Hernáez, Á; Gale, CR; Batty, GD |
| Source: |
Preventive Medicine Reports , 23 , Article 101461. (2021) |
| Publication Year: |
2021 |
| Collection: |
University College London: UCL Discovery |
| Subject Terms: |
COVID-19; Cohort study; HDL-C; UK Biobank |
| Description: |
There is growing evidence of, and biological plausibility for, elevated levels of high-density lipoprotein cholesterol (HDL-C) being related to lower rates of respiratory disease. We tested whether pre-pandemic HDL-C within the normal range is associated with subsequent COVID-19 hospitalisations and death. We analysed data on participants from UK Biobank, a prospective cohort study, baseline data for which were collected between 2006 and 2010. Follow-up for COVID-19 was via hospitalisation records (1845 events in 317,306 individuals) and a national mortality registry (458 deaths in 317,833 individuals). After controlling for a series of confounding factors which included health behaviours, inflammatory markers, and socio-economic status, higher levels of HDL-C were related to a lower risk of later hospitalisation. The effect was linear (p-value for trend 0.001), whereby a 0.2 mmol/L increase in HDL-C was associated with a 7% lower risk (odds ratio; 95% confidence interval: 0.93; 0.90, 0.96). Corresponding relationships for mortality were markedly weaker, such that statistical significance at conventional levels were not apparent for both the linear trend (p-value 0.25) and the odds ratio per 0.2 mmol/L increase (0.98; 0.91, 1.05). While our finding for HDL-C and hospitalisations for COVID-19 raise the possibility that favourable modification of this cholesterol fraction via lifestyle changes or drug intervention may impact upon the risk of the disease, it warrants testing in other studies. |
| Document Type: |
article in journal/newspaper |
| File Description: |
text |
| Language: |
English |
| Relation: |
https://discovery.ucl.ac.uk/id/eprint/10130868/ |
| Availability: |
https://discovery.ucl.ac.uk/id/eprint/10130868/1/Batty_Association%20of%20pre-pandemic%20high-density%20lipoprotein%20cholesterol%20with%20risk%20of%20COVID-19%20hospitalisation%20and%20death-%20The%20UK%20Biobank%20cohort%20study_VoR.pdf; https://discovery.ucl.ac.uk/id/eprint/10130868/ |
| Rights: |
open |
| Accession Number: |
edsbas.84B360D2 |
| Database: |
BASE |