| Title: |
HIV-1 subtype influences susceptibility and response to monotherapy with the protease inhibitor lopinavir/ritonavir. |
| Authors: |
Sutherland, KA; Ghosn, J; Gregson, J; Mbisa, JL; Chaix, ML; Cohen Codar, I; Delfraissy, JF; Delaugerre, C; Gupta, RK |
| Publisher Information: |
Oxford University Press (OUP) |
| Publication Year: |
2014 |
| Collection: |
London School of Hygiene & Tropical Medicine: LSHTM Research Online |
| Description: |
OBJECTIVE: PI susceptibility results from a complex interplay between protease and Gag proteins, with Gag showing wide variation across HIV-1 subtypes. We explored the impact of pre-treatment susceptibility on the outcome of lopinavir/ritonavir monotherapy. METHODS: Treatment-naive individuals who experienced lopinavir/ritonavir monotherapy failure from the MONARK study were matched (by subtype, viral load and baseline CD4 count) with those who achieved virological response ('successes'). Successes were defined by viral load |
| Document Type: |
article in journal/newspaper |
| File Description: |
text |
| Language: |
English |
| ISSN: |
0305-7453 |
| Relation: |
https://researchonline.lshtm.ac.uk/id/eprint/1924965/1/dku365.pdf; Sutherland, KA; Ghosn, J; Gregson, J ORCID logo; Mbisa, JL; Chaix, ML; Cohen Codar, I; Delfraissy, JF; Delaugerre, C; and Gupta, RK (2014) HIV-1 subtype influences susceptibility and response to monotherapy with the protease inhibitor lopinavir/ritonavir. The Journal of antimicrobial chemotherapy, 70 (1). pp. 243-248. ISSN 0305-7453 DOI:10.1093/jac/dku365 |
| DOI: |
10.1093/jac/dku365 |
| Availability: |
https://researchonline.lshtm.ac.uk/id/eprint/1924965/; https://researchonline.lshtm.ac.uk/id/eprint/1924965/1/dku365.pdf; https://doi.org/10.1093/jac/dku365 |
| Rights: |
cc_by_nc_nd |
| Accession Number: |
edsbas.84C05E67 |
| Database: |
BASE |