A Method to Exploit the Structure of Genetic Ancestry Space to Enhance Case-Control Studies
| Title: | A Method to Exploit the Structure of Genetic Ancestry Space to Enhance Case-Control Studies |
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| Authors: | Bodea, Corneliu A.; Neale, Benjamin M.; Ripke, Stephan; Daly, Mark J.; Devlin, Bernie; Roeder, Kathryn; Barclay M; Peyrin Biroulet L; Chamaillard M; Colombel JF; Cottone M; Croft A; D'Incà R; Halfvarson J; Hanigan K; Henderson P; Hugot JP; Karban A; Kennedy NA; Khan MA; Lémann M; Levine A; Massey D; Milla M; Montgomery GW; Ng SM; Oikonomou I; Peeters H; Proctor DD; Rahier JF; Roberts R; Rutgeerts P; Seibold F; STRONATI, LAURA; Taylor KM; Törkvist L; Ublick K; Van Limbergen J; Van Gossum A; Vatn MH; Zhang H; Zhang W; Andrews JM; Bampton PA; Florin TH; Gearry R; Krishnaprasad K; Lawrance IC; Mahy G; Radford Smith G; Roberts RL; Simms LA; Amininijad L; Cleynen I; Dewit O; Franchimont D; Georges M; Laukens D; Theatre E; Vermeire S; Aumais G; Baidoo L; Barrie AM 3rd; Beck K; Bernard EJ; Binion DG; Bitton A; Brant SR; Cho JH; Cohen A; Croitoru K; Daly MJ; Datta LW; Deslandres C; Duerr RH; Dutridge D; Ferguson J; Fultz J; Goyette P; Greenberg GR; Haritunians T; Jobin G; Katz S; Lahaie RG; McGovern DP; Nelson L; Ning K; Paré P; Regueiro MD; Rioux JD; Ruggiero E; Schumm LP; Schwartz M; Scott R; Sharma Y; Silverberg MS; Spears D; Steinhart AH; Stempak JM; Swoger JM; Tsagarelis C; Zhang C; Zhao H; Aerts J; Ahmad T; Arbury H; Attwood A; Auton A; Ball SG; Balmforth AJ; Barnes C; Barrett JC; Barroso I; Barton A; Bennett AJ; Bhaskar S; Blaszczyk K; Bowes J; Brand OJ; Braund PS; Bredin F; Breen G; Brown MJ; Bruce IN; Bull J; Burren OS; Burton J; Byrnes J; Caesar S; Cardin N; Clee CM; Coffey AJ; Connell JM; Conrad DF; Cooper JD; Dominiczak AF; Downes K; Drummond HE; Dudakia D; Dunham A; Ebbs B; Eccles D; Edkins S; Edwards C; Elliot A; Emery P; Evans DM; Evans G; Eyre S; Farmer A. 1st; Ferrier N; Flynn E; Forbes A; Forty L; Franklyn JA; Frayling TM; Freathy RM; Giannoulatou E; Gibbs P; Gilbert P; Gordon Smith K; Gray E; Green E; Groves CJ; Grozeva D; Gwilliam R; Hall A; Hammond N; Hardy M; Harrison P; Hassanali N; Hebaishi H; Hines S; Hinks A; Hitman GA; Hocking L; Holmes C; Howard E; Howard P; Howson JM; Hughes D; Hunt S; Isaacs JD; Jain M; Jewell DP; Johnson T; Jolley JD; Jones IR; Jones LA; Kirov G; Langford CF; Lango Allen H; Lathrop GM; Lee J; Lee KL; Lees C; Lewis K; Lindgren CM; Maisuria Armer M; Maller J; Mansfield J; Marchini JL; Martin P; Massey DC; McArdle WL; McGuffin P; McLay KE; McVean G; Mentzer A; Mimmack ML; Morgan AE; Morris AP; Mowat C; Munroe PB; Myers S; Newman W; Nimmo ER; O'Donovan MC; Onipinla A; Ovington NR; Owen MJ; Palin K; Palotie A; Parnell K; Pearson R; Pernet D; Perry JR; Phillips A; Plagnol V; Prescott NJ; Prokopenko I; Quail MA; Rafelt S; Rayner NW; Reid DM; Renwick A; Ring SM; Robertson N; Robson S; Russell E; St Clair D; Sambrook JG; Sanderson JD; Sawcer SJ; Schuilenburg H; Scott CE; Seal S; Shaw Hawkins S; Shields BM; Simmonds MJ; Smyth DJ; Somaskantharajah E; Spanova K; Steer S; Stephens J; Stevens HE; Stirrups K; Stone MA; Strachan DP; Su Z; Symmons DP; Thompson JR; Thomson W; Tobin MD; Travers ME; Turnbull C; Vukcevic D; Wain LV; Walker M; Walker NM; Wallace C; Warren Perry M; Watkins NA; Webster J; Weedon MN; Wilson AG; Woodburn M; Wordsworth BP; Yau C; Young AH; Zeggini E; Brown MA; Burton PR; Caulfield MJ; Compston A; Farrall M; Gough SC; Hall AS; Hattersley AT; Hill AV; Mathew CG; Pembrey M; Satsangi J; Stratton MR; Worthington J; Hurles ME; Duncanson A; Ouwehand WH; Parkes M; Rahman N; Todd JA; Samani NJ; Kwiatkowski DP; McCarthy MI; Craddock N; Deloukas P; Donnelly P; Blackwell JM; Bramon E; Casas JP; Corvin A; Jankowski J; Markus HS; Palmer CN; Plomin R; Rautanen A; Trembath RC; Viswanathan AC; Wood NW; Spencer CC; Band G; Bellenguez C; Freeman C; Hellenthal G; Pirinen M; Strange A; Blackburn H; Bumpstead SJ; Dronov S; Gillman M; Jayakumar A; McCann OT; Liddle J; Potter SC; Ravindrarajah R; Ricketts M; Waller M; Weston P; Widaa S; Whittaker P. |
| Contributors: | Bodea, Corneliu A.; Neale, Benjamin M.; Ripke, Stephan; Daly, Mark J.; Devlin, Bernie; Roeder, Kathryn; Barclay, M; Peyrin Biroulet, L; Chamaillard, M; Colombel, Jf; Cottone, M; Croft, A; D'Incà, R; Halfvarson, J; Hanigan, K; Henderson, P; Hugot, Jp; Karban, A; Kennedy, Na; Khan, Ma; Lémann, M; Levine, A; Massey, D; Milla, M; Montgomery, Gw; Ng, Sm; Oikonomou, I; Peeters, H; Proctor, Dd; Rahier, Jf; Roberts, R; Rutgeerts, P; Seibold, F; Stronati, Laura; Taylor, Km; Törkvist, L; Ublick, K; Van Limbergen, J; Van Gossum, A; Vatn, Mh; Zhang, H; Zhang, W; Andrews, Jm; Bampton, Pa; Florin, Th; Gearry, R; Krishnaprasad, K; Lawrance, Ic; Mahy, G; Radford Smith, G; Roberts, Rl; Simms, La; Amininijad, L; Cleynen, I; Dewit, O; Franchimont, D; Georges, M; Laukens, D; Theatre, E; Vermeire, S; Aumais, G; Baidoo, L; Barrie AM, 3rd; Beck, K; Bernard, Ej; Binion, Dg; Bitton, A; Brant, Sr; Cho, Jh; Cohen, A; Croitoru, K; Daly, Mj; Datta, Lw; Deslandres, C; Duerr, Rh; Dutridge, D; Ferguson, J; Fultz, J; Goyette, P; Greenberg, Gr; Haritunians, T; Jobin, G; Katz, S; Lahaie, Rg; Mcgovern, Dp; Nelson, L; Ning, K; Paré, P; Regueiro, Md; Rioux, Jd; Ruggiero, E |
| Publisher Information: | Cell Press |
| Publication Year: | 2016 |
| Collection: | Sapienza Università di Roma: CINECA IRIS |
| Subject Terms: | Genetic; Genetics (clinical) |
| Description: | One goal of human genetics is to understand the genetic basis of disease, a challenge for diseases of complex inheritance because risk alleles are few relative to the vast set of benign variants. Risk variants are often sought by association studies in which allele frequencies in case subjects are contrasted with those from population-based samples used as control subjects. In an ideal world we would know population-level allele frequencies, releasing researchers to focus on case subjects. We argue this ideal is possible, at least theoretically, and we outline a path to achieving it in reality. If such a resource were to exist, it would yield ample savings and would facilitate the effective use of data repositories by removing administrative and technical barriers. We call this concept the Universal Control Repository Network (UNICORN), a means to perform association analyses without necessitating direct access to individual-level control data. Our approach to UNICORN uses existing genetic resources and various statistical tools to analyze these data, including hierarchical clustering with spectral analysis of ancestry; and empirical Bayesian analysis along with Gaussian spatial processes to estimate ancestry-specific allele frequencies. We demonstrate our approach using tens of thousands of control subjects from studies of Crohn disease, showing how it controls false positives, provides power similar to that achieved when all control data are directly accessible, and enhances power when control data are limiting or even imperfectly matched ancestrally. These results highlight how UNICORN can enable reliable, powerful, and convenient genetic association analyses without access to the individual-level data. ; One goal of human genetics is to understand the genetic basis of disease, a challenge for diseases of complex inheritance because risk alleles are few relative to the vast set of benign variants. Risk variants are often sought by association studies in which allele frequencies in case subjects are contrasted ... |
| Document Type: | article in journal/newspaper |
| File Description: | STAMPA |
| Language: | English |
| Relation: | info:eu-repo/semantics/altIdentifier/pmid/27087321; info:eu-repo/semantics/altIdentifier/wos/WOS:000375869300005; volume:98; issue:5; firstpage:857-68; lastpage:868; journal:AMERICAN JOURNAL OF HUMAN GENETICS; http://hdl.handle.net/11573/871143; http://www.elsevier.com/wps/find/journaldescription.cws_home/713561/description#description |
| DOI: | 10.1016/j.ajhg.2016.02.025 |
| Availability: | http://hdl.handle.net/11573/871143; https://doi.org/10.1016/j.ajhg.2016.02.025; http://www.elsevier.com/wps/find/journaldescription.cws_home/713561/description#description |
| Rights: | info:eu-repo/semantics/restrictedAccess |
| Accession Number: | edsbas.8562E39E |
| Database: | BASE |