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The management of complicated colorectal cancer in older patients in a global perspective after COVID-19: the CO-OLDER WSES project

Title:	The management of complicated colorectal cancer in older patients in a global perspective after COVID-19: the CO-OLDER WSES project
Authors:	Belinda DE Simone; Fikri M Abu-Zidan; Mauro Podda; Gianluca Pellino; Massimo Sartelli; Federico Coccolini; Salomone DI Saverio; Walter L Biffl; Haytham M Kaafarani; Ernest E Moore; Jugdeep K Dhesi; Susan Moug; Luca Ansaloni; Nicola Avenia; Fausto Catena; Julio Abba; Ahmed Abdelrahman; Wafaa Abdelsalam; Mustapha M Abdullahi; Henry O Abiyere; Godwin Y Abrak; Dmitry Adamovich; Ademola Adeyeye; Malika Adghar; Ehis Afeikhena; Ervis Agastra; Ferdinando Agresta; Fazal Ahmad; Alberto Aiolfi; Ursu Alexandr; Mustafa C Alikli; Vasilescu Alin; Issam Al-Najami; Ahmed Alsayari; Yüksel Altinel; Yasemin Altintas; Bruno Amato; Bashir Aminu; Michele Ammendola; Giorgio Ammerata; Mingoli Andrea; Jacopo Andreuccetti; Elissavet Anestiadou; Boyko Atanasov; Semra D Atici; Selmy Awad; Mustapha Babatunde; Miklosh Bala; Alessandro Balani; Andrea Balla; Ana I Barbancho; Mirko Barone; Mehmet Bayrak; Nikolay Belev; María N Bellenda; Juan Beltrán DE Heredia; Rami Benhmida; Valentin Bereshchenko; Carlo Bergamini; Facundo Berhouet; Maria V Bermudez; Elisa Bertilone; Trilling Bertrand; Hamza W Bhatti; Alan Biloslavo; Antonio Biondi; Santino A Biondo; Francesca Blasi; Florin Bobarca; Davide Bona; Michele Bonomo; Andrea Bottari; Vincenzo Bottino; Konstantinos Bouchagier; Gioia Brachini; Matei Bratu; Antonio Brillantino; Ismael Brito Toledo; Francesco Brucchi; Nihat Buğdayci; Elisa Burti; Ciorbagiu M Calin; Goker Calis; Valentin Calu; Francesca Cammelli; Manuela Cammelli; Rossella D Campa; Aras E Canda; Alfonso Canfora; Ilaria Canfora; Giorgio Cangioni; Alessandro Cannavera; Marco Cannistrà; Gian L Canu; Gabriella T Capolupo; Federico Cappellacci; Filippo Carannante; Luca Cardinali; Marco Caricato; Virginia J Carneros; Gianmaria Casoni Pattacini; Ana M Castillo; Maurizio Castriconi; Alexandros Chamzin; Ambra Chiappini; Mircea Chirica; Sharfuddin Chowdhury; Isaac Chukwu; Fabio Cianchi; Pasquale Cianci; Ahmet B Ciftci; Nicola Cillara; Mihai C Ciorbagiu; Roberto Cirocchi; Cezar Ciubotaru; Oded Cohen-Arazi; Elif Colak; Andrea Coppola; Francesco Coratti; Christian Cotsoglou; Felipe Couto Gomes; Michele Cricrì; Daniele Crocetti; Yunfeng Cui; Vladica Cuk; Roland Cule; Silvia Curcio; Giuseppe Currò; Giuseppe Cuticone; Corrado DA Lio; Fabrizio D'Acapito; Valentina Dadomo; Beatriz DE Andrés-Asenjo; Nicola De' Angelis; Michele DE Capua; Alessandro DE Luca; Giuseppe M DE Luca; Laura DE Martis; Christopher Delaney; Spiros Delis; Marcello Della Corte; Daniele Delogu; Paolo Delrio; Zaza Demetrashvili; Norma Depalma; Antonello Deserra; Agnese Dezi; Isidoro DI Carlo; Deborah DI Carlo Scotto; Pierpaolo DI Lascio; Giovanna DI Meo; Bogdan Diaconescu; Manuel Díez-Alonso; Costanza Distefano; Turgut Donmez; Christos Doudakmanis; Girard Edouard; Mohamed Elbahnasawy; Doaa Elkafrawy; Ane Emaldi-Abasolo; Octavian Enciu; Giorgio Ercolani; Enrico Erdas; Beniamino Esposito; Begoña Estraviz-Mateos; Giuseppe Evola; Olufemi Fatudimu; Jean L Faucheron; Daniel M Felsenreich; Laura Fernández-Gómez Cruzado; Francesco Feroci; Enrico Fiori; Francesca Flamini; Francesco Fleres; Laura Fortuna; Evangelos Fradelos; Joseph Froud; Maximos Frountzas; Gaetano Gallo; Alessandro Garcea; Julian Z García; Carlos García Sánchez; Allende Garcia Sierra; Ibrahim-Umar Garzali; Paola Germani; Rojnoveanu Gheorghe; Nicolae Gica; Alessio Giordano; Antonio Giuliani; Michela Giulii Capponi; Ugo Giustizieri; Mario Godina; Carlos A Gomes; Juan C Gomez Rosado; Svetlana M Gramatiuk; Roberta Granata; Stefano Granieri; Gianpiero Gravante; Jan Grosek; Ugo Grossi; Tommaso Guagni; Anna Guariniello; Barbara Habrat; Dimitar Hadzhiev; Elena Hadzhieva; Hassisi Hakim; Albasheer Hamadalnile; Mohamad F Hayati; Andreas Hecker; Juan G Holguin; Immacolata Iannone; Argyrios Ioannidis; Orestis Ioannidis; Massimo Ippoliti; Mercy Isichei; Giovanni Iside; Arda Isik; Yulia V Ivanova; Ana Izquierdo-Moreno; Ariel Joiris; Jovan Juloski; Houshang Kalamian; Stylianos Kapiris; Yasin Kara; Mehmet Karabulut; Dimitrios Karakaxas; Aleksandar Karamarkovic; Ioannis Katsaros; Deborah Keller; Myrto Keramida; Bharti Kewlani; Kakhi Khutsishvili; Konstantinos Konstantinidis; Michael Konstantinidis; Dimitrios Korkolis; Mohammed J Korkoman; Jurij A Košir; Igor A Kryvoruchko; Andrzej Kwiatkowski; Fotios Kyramargios; Aitor Landaluce-Olavarria; Giuliano Lantone; Christo Lapa; Pierfrancesco Lapolla; Vito Laterza; Silvio Laureti; Manolo Leon-Valarezo; Pasquale Lepiane; Luca Lepre; Arnaud Liagre; Dimitrios Linardoutsos; Celine E Lindqvist Neergaard; Andrey Litvin; Varut Lohsiriwat; José A Lopez-Ruiz; Pasquale Losurdo; Andrea Lucchi; Gaetano Luglio; Davide Luppi; Nikolaos Machairas; Fausto Madrid; Jin-Juin Mah; Piotr Major; Jerry G Makama; Maryam Makki; Tatiana Malcova; Michele Manara; Dimitrios Manatakis; Sarah Mansour; Denise Marchesini; Beatriz Marenco DE LA Cuadra; Athanasios Marinis; John Marks; José Martín-Arévalo; Laura Martinez; Maria J Martinez; Francesco Martini; Vasily Martynyuk; Lorena Massante; Manuela Mastronardi; Belén Matías-García; Edward Matthews; Maciej Matyja; Eleni Mavrodimitraki; Michele Mazza; Cosimo Mazzei; Carmelo Mazzeo; Antonio R Medina; Fernando Mendoza-Moreno; Nunzia Menduni; Simona Meneghini; Paola Menegon; Serhat Meriç; David Merlini; Ilenia Merlini; Cristian Mesina; Michelangelo Miccini; Nikolaos Michalopoulos; Andrea Mingoli; Isabella Mondi; Giulia Montori; Mauro Montuori; David Moro-Valdezate; Vasileios Mousafeiris; Felice Mucilli; Abubakar B Muhammad; Umar Muktar; Francesk Mulita; Virginia D Muñoz-Cruzado; Gabriela A Murillo; Valentina Murzi; Adam Mylonakis; Nasiru T Nagwamutse; Bruno Nardo; Ionut Negoi; Vasiliki Nikolaou; Alexander Obando; Fabio M Oddi; Nnanna Okpa; Kenneth Okpokiri; Aitor L Olavarria; Peter Onuminya; Victor J Ovejero; Mario Pacilli; Daniele Paglione; Abhilash Paily; Anna Palepa; Giuseppe Palomba; Paolo Panaccio; Mario Pannullo; Farah Pantaran; Diana A Pantoja Pachajoa; Mario V Papa; Maria Papadoliopoulou; Aristeidis Papadopoulos; Miltiades Papastamatiou; Felipe Pareja Ciuró; Kyrylo Y Parkhomenko; Chetan Parmar; Giovanni Pascale; Alessandro Pasculli; Nicola Passuello; Francesco Pata; Giovanna Pavone; Nikhil Pawa; Michał Pędziwiatr; Rossana Percario; Jeny R Perez; Davina Perini; Benedetta Pesi; Barbara Petronio; Niccolò Petrucciani; Luigi Piazza; Enrico Piazzese; Biagio Picardi; Arcangelo Picciariello; Micaela Piccoli; Silvia Picotto; Giusto Pignata; Enrico Pinotti; Raffaele Pirozzi; Michail Pizanias; Enrico Potenza; Giuseppa Procida; Kostiantyn A Prokopenko; Irma Pucciatti; Alessandro Puzziello; Maria M Ramos; Maria C Ranucci; Alberto Realis Luc; Daniela Rega; Martin Reichert; Thais Reif DE Paula; Andrey Renghin; Francesco Renzi; Marryam Riaz Farooqui; Marcelo Ribeiro Jr Jr; Francesco Ricci; Uriel N Rivas Mendoza; Stefania Romano; Luigi Romeo; Fausto Rosa; Alba Rosario; Stefano Rossi; Simone Rossi Del Monte; María Ruiz-Soriano; Justyna Rymarowicz; Sonia Sabbatini; Yashwant Sakaray; Edoardo Saladino; Konstantinos Saliaris; Daniele Sannino; Mauro Santarelli; Paolo Sapienza; Federica Saraceno; Aikaterini Sarafi; Giacomo Sarzo; Francesca Sbuelz; Alessia Scarton; Carlo A Schena; Georgia Schismenou; Dimitrios Schizas; Fabrizio Scognamillo; Giuseppe Sena; Elisabetta Seno; Vivekanand Sharma; Abdulrahman-Abba Sheshe; Theodoros Sidiropoulos; Anastasya Sidorenko; Eleonora Silanos; Gianfranco Silecchia; Pierpaolo Sileri; Eugenia Sinatti; Francesca Sivieri; Mihail Slavchev; Rostyslav M Smachylo; Neil Smart; Satish Sn; Leonardo Solaini; Maria Sotiropoulou; Marcello G Spampinato; Eleftherios Spartalis; Michael Spartalis; Simone Squillante; Bogdan Stoica; Ibrahim-Eneye Suleiman; Mohamed A Sultan; Maciej Szura; Fillali Tahar; Mariarita Tarallo; Maddalena Tarricone; Nicola Tartaglia; Anna Taseva; Nikolaos Tasis; Aikaterini Tata; Giovanni Tebala; Adrián Teran; Mustafa C Terzi; Mario Testini; Pallavi Thakare; Panagiotis Theodorou; Pier L Tilocca; Adelina E Toma; Elena A Toma; Ivan Tomasi; Giovanni Tomasicchio; Aleš Tomažič; Beatrice Torre; Paola Tramelli; Giuseppe Trigiante; Mario Trompetto; Francesca P Tropeano; Ana Tvaladze; Benjamin Ugwu; Muktar Umar; Katarzyna Urbanska; Mariasole Urgo; Mustafa Y Uzunoglu; Carla Vaccaro; Michail Vailas; Ainhoa Valle Rubio; Dirk VAN DE Putte; Yves VAN Nieuwenhove; Gabrielle VAN Ramshorst; Cristopher Varela; Obleaga C Vasile; Daunia Verdi; Massimiliano Veroux; Georgios-Ioannis Verras; Francesca Vescio; Edibel S Vicent; Andrea Vignali; Nathalie Villan Ramirez; Diego Visconti; Nutu Vlad; Maciej Walędziak; Imtiaz Wani; Michael P Wong; Omer Yalkin; Hakan Yigitbas; Gülseren Yilmaz; Muhammad U Younis; Claudia Zaghi; Andee D Zakaria; Zaidi Zakaria; Martina Zambon; Nikolaos Zampitis; Konstantinos Zapsalis; Marcin Zawadzki; Nadezhda Zubareva
Contributors:	DE Simone, Belinda; M Abu-Zidan, Fikri; Podda, Mauro; Pellino, Gianluca; Sartelli, Massimo; Coccolini, Federico; DI Saverio, Salomone; L Biffl, Walter; M Kaafarani, Haytham; E Moore, Ernest; K Dhesi, Jugdeep; Moug, Susan; Ansaloni, Luca; Avenia, Nicola; Catena, Fausto; Abba, Julio; Abdelrahman, Ahmed; Abdelsalam, Wafaa; M Abdullahi, Mustapha; O Abiyere, Henry; Y Abrak, Godwin; Adamovich, Dmitry; Adeyeye, Ademola; Adghar, Malika; Afeikhena, Ehi; Agastra, Ervi; Agresta, Ferdinando; Ahmad, Fazal; Aiolfi, Alberto; Alexandr, Ursu; C Alikli, Mustafa; Alin, Vasilescu; Al-Najami, Issam; Alsayari, Ahmed; Altinel, Yüksel; Altintas, Yasemin; Amato, Bruno; Aminu, Bashir; Ammendola, Michele; Ammerata, Giorgio; Andrea, Mingoli; Andreuccetti, Jacopo; Anestiadou, Elissavet; Atanasov, Boyko; D Atici, Semra; Awad, Selmy; Babatunde, Mustapha; Bala, Miklosh; Balani, Alessandro; Balla, Andrea; I Barbancho, Ana; Barone, Mirko; Bayrak, Mehmet; Belev, Nikolay; N Bellenda, María; Beltrán DE Heredia, Juan; Benhmida, Rami; Bereshchenko, Valentin; Bergamini, Carlo; Berhouet, Facundo; V Bermudez, Maria; Bertilone, Elisa; Bertrand, Trilling; W Bhatti, Hamza; Biloslavo, Alan; Biondi, Antonio; A Biondo, Santino; Blasi, Francesca; Bobarca, Florin; Bona, Davide; Bonomo, Michele; Bottari, Andrea; Bottino, Vincenzo; Bouchagier, Konstantino; Brachini, Gioia; Bratu, Matei; Brillantino, Antonio; Brito Toledo, Ismael; Brucchi, Francesco; Buğdayci, Nihat; Burti, Elisa; M Calin, Ciorbagiu; Calis, Goker; Calu, Valentin; Cammelli, Francesca; Cammelli, Manuela; D Campa, Rossella; E Canda, Ara; Canfora, Alfonso; Canfora, Ilaria; Cangioni, Giorgio; Cannavera, Alessandro; Cannistrà, Marco; L Canu, Gian; T Capolupo, Gabriella; Cappellacci, Federico; Carannante, Filippo; Cardinali, Luca; Caricato, Marco; J Carneros, Virginia
Publication Year:	2024
Collection:	Università del Salento: CINECA IRIS
Subject Terms:	Aged; Colorectal neoplasm; Emergencie; Frailty; Medical futility; Operative surgical procedures
Description:	BACKGROUND: Colorectal (CRC) cancer is becoming a disease of the elderly. Ageing is the most significant risk factor for presenting CRC. Early diagnosis of CRC and management is the best way in achieving good outcomes and longer survival but patients aged ≥75 years are usually not screened for CRC. This group of patients is often required to be managed when they are symptomatic in the emergency setting with high morbidity and mortality rates. Our main aim is to provide clinical data about the management of elderly patients presenting complicated colorectal cancer who required emergency surgical management to improve their care. METHODS: The management of complicated COlorectal cancer in OLDER patients (CO-OLDER; ClinicalTrials.gov ID: NCT05788224; evaluated by the local ethical committee CPP EST III-France with the national number 2023-A01094-41) in the emergency setting project provides carrying out an observational multicenter international cohort study aimed to collect data about patients aged ≥75 years to assess modifiable risk factors for negative outcomes and mortality correlated to the emergency surgical management of this group of patients at risk admitted with a complicated (obstructed and perforated) CRC. The CO-OLDER protocol was approved by Institutional Review Board and released. Each CO-OLDER collaborator is asked to enroll ≥25 patients over a study period from 1st January 2018 to 30th October 2023. Data will be analyzed comparing two periods of study: before and after the COVID-19 pandemic. A sample size of 240 prospectively enrolled patients with obstructed colorectal cancer in a 5-month period was calculated. The secured database for entering anonymized data will be available for the period necessary to achieve the highest possible participation. RESULTS: One hundred eighty hospitals asked to be a CO-OLDER collaborator, with 36 potentially involved countries over the world. CONCLUSIONS: The CO-OLDER project aims to improve the management of elderly people presenting with a complicated colorectal ...
Document Type:	article in journal/newspaper
File Description:	STAMPA
Language:	English
Relation:	volume:79; journal:MINERVA SURGERY; https://hdl.handle.net/11587/543386
DOI:	10.23736/s2724-5691.23.10165-1
Availability:	https://hdl.handle.net/11587/543386; https://doi.org/10.23736/s2724-5691.23.10165-1
Accession Number:	edsbas.8568C375
Database:	BASE