| Title: |
Risk of non-small cell lung cancer and the cytochrome P4501A1 Ile462Val polymorphism |
| Authors: |
Larsen, Jill Everland; Colosimo, Maree Louise; Yang, Ian Anthony; Bowman, Rayleen; Zimmerman, Paul Victor; Fong, Kwun Meng |
| Publisher Information: |
Springer |
| Publication Year: |
2005 |
| Collection: |
The University of Queensland: UQ eSpace |
| Subject Terms: |
Cytochrome P450cyp1a1; Carcinoma; Non-small-cell Lung; Polymorphism (genetics); Genetic Predisposition To Disease; Oncology; Public; Environmental & Occupational Health; Genetic Polymorphisms; Cyp1a1 Polymorphisms; Cigarette-smoking; Pooled Analysis; United-states; Exon 7; Susceptibility; Adenocarcinoma; Association; Population; C1 |
| Description: |
Objective: The Ile462Val substitution in the cytochrome P450 1A1 gene (CYP1A1) results in increased enzymatic activity. Preliminary data suggesting a link between this polymorphism and lung cancer risk in Caucasians are inconsistent, reflecting small sample sizes and the relatively low frequency of the variant. Methods: The data set consisted of 1050 primary non-small cell lung cancer cases and 581 controls, a large homogenous population designed specifically to address previous inconsistencies. Patients were genotyped using a PCR-RFLP technique. Results: Carriers of the valine allele, CYP1A1*2C, (Ile/Val or Val/Val genotypes) were significantly over-represented in non-small cell lung cancer compared to controls (OR=1.9; 95% CI=1.2-2.9; p=0.005) when adjusted for confounders, particularly in women (OR=4.6; 95% CI=1.7-12.4; p=0.003). The valine variant was statistically significantly over-represented in cases of lung cancer younger than the median age (64 years) (OR=2.5; 95% CI=1.3-4.8; p=0.005) and cases with less than the median cumulative tobacco-smoke exposure (46 pack-years) (OR=2.4; 95% CI=1.3-4.7; p=0.007). Conclusions: These new data establish an association between the CYP1A1 Ile462Val polymorphism and the risk of developing non-small cell lung cancer, especially among women. |
| Document Type: |
article in journal/newspaper |
| Language: |
English |
| ISSN: |
0957-5243; 1573-7225 |
| Relation: |
orcid:0000-0001-7806-3931; orcid:0000-0001-8338-1993; orcid:0000-0002-6507-1403 |
| Availability: |
https://espace.library.uq.edu.au/view/UQ:75779 |
| Accession Number: |
edsbas.859B3671 |
| Database: |
BASE |