| Title: |
129Xe-MRI ventilation and acinar abnormalities highlight the significance of spirometric dysanapsis: findings from the NOVELTY ADPro UK substudy |
| Authors: |
Smith, Laurie J; Marshall, Helen; Jakymelen, Demi; Biancardi, Alberto; Collier, Guilhem J; Chan, Ho-Fung; Hughes, Paul J C; Brook, Martin L; Astley, Josh R; Munro, Ryan; Rajaram, Smitha; Swift, Andrew J; Capener, David; Bray, Jody; Ball, Jimmy E; Rodgers, Oliver; Tahir, Bilal A; Rao, Madhwesha; Norquay, Graham; Weatherley, Nicholas D; Armstrong, Leanne; Hardaker, Latife; Papi, Alberto; Hughes, Rod; Wild, Jim M |
| Contributors: |
Smith, Laurie J; Marshall, Helen; Jakymelen, Demi; Biancardi, Alberto; Collier, Guilhem J; Chan, Ho-Fung; Hughes, Paul J C; Brook, Martin L; Astley, Josh R; Munro, Ryan; Rajaram, Smitha; Swift, Andrew J; Capener, David; Bray, Jody; Ball, Jimmy E; Rodgers, Oliver; Tahir, Bilal A; Rao, Madhwesha; Norquay, Graham; Weatherley, Nicholas D; Armstrong, Leanne; Hardaker, Latife; Papi, Alberto; Hughes, Rod; Wild, Jim M |
| Publication Year: |
2025 |
| Collection: |
Università degli Studi di Ferrara: CINECA IRIS |
| Subject Terms: |
Imaging/CT MRI etc; lung physiology; respiratory measurement |
| Description: |
Rationale: Airways dysanapsis is defined by CT or spirometry as a mismatch between the size of the airways and lung volume and is associated with increased risk of developing chronic obstructive pulmonary disease (COPD). Lung disease in participants with dysanapsis and a label of asthma and/or COPD remains poorly understood. Methods: In participants with asthma and/or COPD, we used 129Xe-MRI to assess ventilation, acinar dimensions and gas exchange, and pulmonary function tests, and compared people with spirometric dysanapsis (forced expiratory volume in 1 s (FEV1)/forced vital capacity (FVC)-1.64 z) to those with normal spirometry (FEV1, FVC and FEV1/FVC>-1.64 z). Results: From 165 participants assessed in the NOVELTY (NOVEL observational longiTudinal studY) ADPro (advanced diagnostic profiling) study with a physician-assigned diagnosis of asthma and/or COPD, 43 had spirometric dysanapsis and were age-matched to 43 participants with normal spirometry. Participants with dysanapsis had significantly increased ventilation defects (median difference (md) (95% CI) = 4.0% (1.42% to 5.38%), p |
| Document Type: |
article in journal/newspaper |
| File Description: |
STAMPA |
| Language: |
English |
| Relation: |
info:eu-repo/semantics/altIdentifier/pmid/40425296; info:eu-repo/semantics/altIdentifier/wos/WOS:001498681600001; volume:80; issue:12; firstpage:909; lastpage:917; numberofpages:9; journal:THORAX; https://hdl.handle.net/11392/2608434; https://thorax.bmj.com/content/80/12/909 |
| DOI: |
10.1136/thorax-2024-222347 |
| Availability: |
https://hdl.handle.net/11392/2608434; https://doi.org/10.1136/thorax-2024-222347; https://thorax.bmj.com/content/80/12/909 |
| Rights: |
info:eu-repo/semantics/openAccess ; license:Creative commons ; license uri:http://creativecommons.org/licenses/by/4.0/ |
| Accession Number: |
edsbas.85A9E1DB |
| Database: |
BASE |