| Title: |
A divergent hepatitis D-like agent in birds |
| Authors: |
Wille, M; Netter, HJ; Littlejohn, M; Yuen, L; Shi, M; Eden, JS; Klaassen, M; Holmes, EC; Hurt, AC |
| Publisher Information: |
MDPI |
| Publication Year: |
2018 |
| Collection: |
The University of Melbourne: Digital Repository |
| Description: |
Hepatitis delta virus (HDV) is currently only found in humans and is a satellite virus that depends on hepatitis B virus (HBV) envelope proteins for assembly, release, and entry. Using meta-transcriptomics, we identified the genome of a novel HDV-like agent in ducks. Sequence analysis revealed secondary structures that were shared with HDV, including self-complementarity and ribozyme features. The predicted viral protein shares 32% amino acid similarity to the small delta antigen of HDV and comprises a divergent phylogenetic lineage. The discovery of an avian HDV-like agent has important implications for the understanding of the origins of HDV and sub-viral agents. |
| Document Type: |
article in journal/newspaper |
| Language: |
English |
| ISSN: |
1999-4915 |
| Relation: |
pii: v10120720; https://hdl.handle.net/11343/253624 |
| Availability: |
https://hdl.handle.net/11343/253624 |
| Rights: |
https://creativecommons.org/licenses/by/4.0 ; CC BY |
| Accession Number: |
edsbas.85E3FDFE |
| Database: |
BASE |