| Title: |
Pulmonary emphysema and coronary artery calcifications at baseline LDCT and long-term mortality in smokers and former smokers of the ITALUNG screening trial |
| Authors: |
Mascalchi M.; Romei C.; Marzi C.; Diciotti S.; Picozzi G.; Pistelli F.; Zappa M.; Paci E.; Carozzi F.; Gorini G.; Falaschi F.; Deliperi A. L.; Camiciottoli G.; Carrozzi L.; Puliti D. |
| Contributors: |
Mascalchi M.; Romei C.; Marzi C.; Diciotti S.; Picozzi G.; Pistelli F.; Zappa M.; Paci E.; Carozzi F.; Gorini G.; Falaschi F.; Deliperi A.L.; Camiciottoli G.; Carrozzi L.; Puliti D. |
| Publication Year: |
2023 |
| Collection: |
IRIS Università degli Studi di Bologna (CRIS - Current Research Information System) |
| Subject Terms: |
Cardiovascular disease; Cause of death; Lung neoplasm; Pulmonary emphysema; Smokers |
| Description: |
Objectives: Cardiovascular disease (CVD), lung cancer (LC), and respiratory diseases are main causes of death in smokers and former smokers undergoing low-dose computed tomography (LDCT) for LC screening. We assessed whether quantification of pulmonary emphysematous changes at baseline LDCT has a predictive value concerning long-term mortality. Methods: In this longitudinal study, we assessed pulmonary emphysematous changes with densitometry (volume corrected relative area below − 950 Hounsfield units) and coronary artery calcifications (CAC) with a 0–3 visual scale in baseline LDCT of 524 participants in the ITALUNG trial and analyzed their association with mortality after 13.6years of follow-up using conventional statistics and a machine learning approach. Results: Pulmonary emphysematous changes were present in 32.3% of subjects and were mild (6% ≤ RA950 ≤ 9%) in 14.9% and moderate-severe (RA950 > 9%) in 17.4%. CAC were present in 67% of subjects (mild in 34.7%, moderate-severe in 32.2%). In the follow-up, 81 (15.4%) subjects died (20 of LC, 28 of other cancers, 15 of CVD, 4 of respiratory disease, and 14 of other conditions). After adjusting for age, sex, smoking history, and CAC, moderate-severe emphysema was significantly associated with overall (OR 2.22; 95CI 1.34–3.70) and CVD (OR 3.66; 95CI 1.21–11.04) mortality. Machine learning showed that RA950 was the best single feature predictive of overall and CVD mortality. Conclusions: Moderate-severe pulmonary emphysematous changes are an independent predictor of long-term overall and CVD mortality in subjects participating in LC screening and should be incorporated in the post-test calculation of the individual mortality risk profile. Key Points: • Densitometry allows quantification of pulmonary emphysematous changes in low-dose CT examinations for lung cancer screening. • Emphysematous lung density changes are an independent predictor of long-term overall and cardio-vascular disease mortality in smokers and former smokers undergoing screening. • ... |
| Document Type: |
article in journal/newspaper |
| File Description: |
ELETTRONICO |
| Language: |
English |
| Relation: |
info:eu-repo/semantics/altIdentifier/pmid/36854875; info:eu-repo/semantics/altIdentifier/wos/WOS:000940744100001; volume:33; issue:5; firstpage:3115; lastpage:3123; numberofpages:9; journal:EUROPEAN RADIOLOGY; https://hdl.handle.net/11585/964510 |
| DOI: |
10.1007/s00330-023-09504-4 |
| Availability: |
https://hdl.handle.net/11585/964510; https://doi.org/10.1007/s00330-023-09504-4; https://link.springer.com/article/10.1007/s00330-023-09504-4 |
| Rights: |
info:eu-repo/semantics/openAccess |
| Accession Number: |
edsbas.85FA6C39 |
| Database: |
BASE |