| Title: |
Genetic Landscape of Prostate Cancer Conspicuity on Multiparametric Magnetic Resonance Imaging: A Systematic Review and Bioinformatic Analysis |
| Authors: |
Norris, JM; Simpson, BS; Parry, MA; Allen, C; Ball, R; Freeman, A; Kelly, D; Kim, HL; Kirkham, A; You, S; Kasivisvanathan, V; Whitaker, HC; Emberton, M |
| Source: |
European Urology Open Science , 20 pp. 37-47. (2020) |
| Publication Year: |
2020 |
| Collection: |
University College London: UCL Discovery |
| Subject Terms: |
Bioinformatic analysis; Genetics; Genomics; Multiparametric magnetic resonance imaging; Prostate cancer; Systematic review |
| Description: |
CONTEXT: Multiparametric magnetic resonance imaging (mpMRI) detects most, but not all, clinically significant prostate cancer. The genetic basis of prostate cancer visibility and invisibility on mpMRI remains uncertain. OBJECTIVE: To systematically review the literature on differential gene expression between mpMRI-visible and mpMRI-invisible prostate cancer, and to use bioinformatic analysis to identify enriched processes or cellular components in genes validated in more than one study. EVIDENCE ACQUISITION: We performed a systematic literature search of the Medline, EMBASE, PubMed, and Cochrane databases up to January 2020 in accordance with the Preferred Reporting Items for Systematic Reviews and Meta-analyses (PRISMA) statement. The primary endpoint was differential genetic features between mpMRI-visible and mpMRI-invisible tumours. Secondary endpoints were explanatory links between gene function and mpMRI conspicuity, and the prognostic value of differential gene enrichment. EVIDENCE SYNTHESIS: We retrieved 445 articles, of which 32 met the criteria for inclusion. Thematic synthesis from the included studies showed that mpMRI-visible cancer tended towards enrichment of molecular features associated with increased disease aggressivity, including phosphatase and tensin homologue (PTEN) loss and higher genomic classifier scores, such as Oncotype and Decipher. Three of the included studies had accompanying publicly available data suitable for further bioinformatic analysis. An over-representation analysis of these datasets revealed increased expression of genes associated with extracellular matrix components in mpMRI-visible tumours. CONCLUSIONS: Prostate cancer that is visible on mpMRI is generally enriched with molecular features of tumour development and aggressivity, including activation of proliferative signalling, DNA damage, and inflammatory processes. Additionally, there appears to be concordant cellular components and biological processes associated with mpMRI conspicuity, as highlighted by ... |
| Document Type: |
article in journal/newspaper |
| File Description: |
text |
| Language: |
English |
| Relation: |
https://discovery.ucl.ac.uk/id/eprint/10108477/1/Genetic%20landscape%20european%20Urol%20open.pdf; https://discovery.ucl.ac.uk/id/eprint/10108477/ |
| Availability: |
https://discovery.ucl.ac.uk/id/eprint/10108477/1/Genetic%20landscape%20european%20Urol%20open.pdf; https://discovery.ucl.ac.uk/id/eprint/10108477/ |
| Rights: |
open |
| Accession Number: |
edsbas.8619E759 |
| Database: |
BASE |