| Title: |
Comparison of lotions, creams, gels and ointments for the treatment of childhood eczema: the BEE RCT |
| Authors: |
Ridd, Matthew J; Wells, Sian; MacNeill, Stephanie J; Sanderson, Emily; Webb, Douglas; Banks, Jonathan; Sutton, Eileen; Shaw, Alison RG; Wilkins, Zoe; Clayton, Julie; Roberts, Amanda; Garfield, Kirsty; Liddiard, Lyn; Barrett, Tiffany J; Lane, J Athene; Baxter, Helen; Howells, Laura; Taylor, Jodi; Hay, Alastair D; Williams, Hywel C; Thomas, Kim S; Santer, Miriam |
| Publisher Information: |
NIHR Journals Library |
| Publication Year: |
2023 |
| Collection: |
University of Nottingham: Repository@Nottingham |
| Subject Terms: |
Child; Eczema - drug therapy; Emollients; Quality of Life; Male; Severity of Illness Index; Female; Humans; Dermatitis; Atopic - chemically induced - drug therapy; Preschool; Ointments - therapeutic use; Cost-Benefit Analysis |
| Description: |
Background: Emollients are recommended for children with eczema (atopic eczema/dermatitis). A lack of head-to-head comparisons of the effectiveness and acceptability of the different types of emollients has resulted in a 'trial and error' approach to prescribing. Objective: To compare the effectiveness and acceptability of four commonly used types of emollients for the treatment of childhood eczema. Design: Four group, parallel, individually randomised, superiority randomised clinical trials with a nested qualitative study, completed in 2021. A purposeful sample of parents/children was interviewed at ≈ 4 and ≈ 16 weeks. Setting: Primary care (78 general practitioner surgeries) in England. Participants: Children aged between 6 months and 12 years with eczema, of at least mild severity, and with no known sensitivity to the study emollients or their constituents. Interventions: Study emollients sharing the same characteristics in the four types of lotion, cream, gel or ointment, alongside usual care, and allocated using a web-based randomisation system. Participants were unmasked and the researcher assessing the Eczema Area Severity Index scores was masked. Main outcome measures: The primary outcome was Patient-Oriented Eczema Measure scores over 16 weeks. The secondary outcomes were Patient-Oriented Eczema Measure scores over 52 weeks, Eczema Area Severity Index score at 16 weeks, quality of life (Atopic Dermatitis Quality of Life, Child Health Utility-9 Dimensions and EuroQol-5 Dimensions, five-level version, scores), Dermatitis Family Impact and satisfaction levels at 16 weeks. Results: A total of 550 children were randomised to receive lotion (analysed for primary outcome 131/allocated 137), cream (137/140), gel (130/135) or ointment (126/138). At baseline, 86.0% of participants were white and 46.4% were female. The median (interquartile range) age was 4 (2-8) years and the median Patient-Oriented Eczema Measure score was 9.3 (SD 5.5). There was no evidence of a difference in mean Patient-Oriented Eczema ... |
| Document Type: |
article in journal/newspaper |
| Language: |
English |
| Relation: |
https://nottingham-repository.worktribe.com/output/27089274; Health Technology Assessment; Volume 27; Issue 19; Pagination 1-120 |
| DOI: |
10.3310/gzqw6681 |
| Availability: |
https://doi.org/10.3310/gzqw6681; https://nottingham-repository.worktribe.com/file/27089274/1/Childhood%20eczema; https://nottingham-repository.worktribe.com/output/27089274 |
| Rights: |
openAccess ; https://creativecommons.org/licenses/by/4.0/ |
| Accession Number: |
edsbas.8693C941 |
| Database: |
BASE |